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Fluoxetine seems to widen the nortriptyline antidepressant-like dose range in mice submitted to the tail suspension test (TST)

Published online by Cambridge University Press:  16 April 2020

IR de Oliveira
Affiliation:
Grupo de Estudos em Neuropsiquiatria e Psicofarmacologia (GENPSI) Laboratório de Neurociências, Departamento de Farmacologia e Fisiologia, ICS, Universidade Federal da Bahia, Vale do Canela, 40140Salvador, Bahia, Brazil
PR Brito
Affiliation:
Grupo de Estudos em Neuropsiquiatria e Psicofarmacologia (GENPSI)
MF Peres
Affiliation:
Grupo de Estudos em Neuropsiquiatria e Psicofarmacologia (GENPSI)
R Dardennes
Affiliation:
Clinique de Maladies Mentales et de l'Encéphale, 100 Rue de la Santé, 75014Paris
MA da Rocha-Junior
Affiliation:
Grupo de Estudos em Neuropsiquiatria e Psicofarmacologia (GENPSI)
J Gonidec
Affiliation:
Laboratoires Delagrange, 1 rue Pierre Brossolete, 91380Chilly-Mazarin, France
T Rouyer
Affiliation:
Laboratoires Delagrange, 1 rue Pierre Brossolete, 91380Chilly-Mazarin, France
E de Castro-E-Silva
Affiliation:
Laboratório de Neurociências, Departamento de Farmacologia e Fisiologia, ICS, Universidade Federal da Bahia, Vale do Canela, 40140Salvador, Bahia, Brazil

Summary

This study was designed to verify whether fluoxetine (FL), a serotonin (5-HT) re-uptake inhibitor, would interfere with nortriptyline (NT), a biphasic U-shaped curvilinear dose-response relationship recently described in our laboratory. We associated 10 mg/kg NT or vehicle to 0, 5, 10, 20 and 40 mg/kg FL, in one group, and 10 mg FL or vehicle to 0, 5, 10, 20 and 40 mg/kg NT, in another group, 30 min before the tail suspension test (TST) in mice. Although we were not able to confirm a synergistic effect between FL and NT, FL-NT association seems to require higher doses of NT to block its own anti-immobility effect at high doses, thus widening NT effective antidepressant-like dose range in mice submitted to TST.

Type
Original article
Copyright
Copyright © Elsevier, Paris 1992

References

Aranow, RBHudson, JIPope, HGGrady, TALaage, TABell, IRCole, JO (1989) Elevated antidepressant plasma levels after addition of fluoxetine Am J Psychiatry 146, 911913Google ScholarPubMed
Asberg, MCronholm, BSjoqvist, FTuck, D (1971) Relationship between plasma levels and therapeutic effect of nortriptyline Br Med J 3, 331334CrossRefGoogle ScholarPubMed
Baron, BMOgden, QMSiegel, BWStegeman, JUrsillo, RCDedley, MW (1988) Rapid down-regulation of betaadrenoceptors by co-administation of desipramine and fluoxetine Eur J Pharmacol 154, 125134CrossRefGoogle Scholar
Beasley, CMBosomworth, JCWernicke, JF(1990) Fluoxetine: Relationships among dose, response, adverse events, and plasma concentrations in the treatment of depression Psychopharmacol Bull 26, 1824Google ScholarPubMed
Bell, IRCole, JO (1988) Fluoxetine induced elevation of desipramine level and exacerbation of geriatric nonpsychotic depression (letter) J Clin Psychopharmacol 8, 447448CrossRefGoogle Scholar
Ciraulo, ADShader, RI (1990) Fluoxetine drug-drug interactions: I. Antidepressants and antipsychotics J Clin Psychopharmacol 10, 4850CrossRefGoogle ScholarPubMed
De Oliveira, IRDiquet, BVan der Meersch, VGonidec, JPrado-Lima, PAS (1989a) Higher blood and brain concentrations of imipramine and desipramine seem not to impair anti-immobility effect in mice Psychiatr & Psychobiol 4, 369373Google Scholar
De Oliveira, IRPrado-Lima, PASSamuel-Lajeunesse, B (1989b) Monitoring of tricyclic antidepressant plasma levels and clinical response: A review of the literature Psychiatr & Psychobiol 4, 4360, 81-90Google Scholar
De Oliveira, IRDiquet, BVan der Meersch, VDardennes, RGonidec, JPrado-Lima, PAS (1990) Self inhibiting action of nortriptyline's anti-immobility effect at high plasma and brain levels in mice Psychopharmacol 102, 553556CrossRefGoogle Scholar
Dunnett, CW (1964) New tables for multiple comparisons with a control Biometrics 20, 483489CrossRefGoogle Scholar
Goodnick, PJ (1989) Influence of fluoxetine on plasma levels of desipramine (letter) Am J Psychiatry 146, 552Google Scholar
Hall, HOgren, SO (1981) Effects of antidepressant drugs on different receptors in the brain Eur J Pharmacol 70, 393407CrossRefGoogle Scholar
Kragh-Sorensen, PHansen, CBaastrup, PCHvidberg, EF (1976) Self-inhibiting action of nortriptyline's antidepressive effect at high plasma levels Psychopharmacol, 45 305312CrossRefGoogle Scholar
Martin, PSoubrié, PPuech, AJ (1990) Reversal of helpless behavior by serotonin uptake blockers in rats Psychopharmacol 101, 403407CrossRefGoogle ScholarPubMed
Nelson, JCMazure, CMBowers, MBJatlow, PI (1991) A preliminary, open study of the combination of fluoxetine and desipramine for rapid treatment of major depression Arch Gen Psychiatry 48, 303307CrossRefGoogle ScholarPubMed
Stéru, LChermat, RThierry, B (1985) The tail suspension test: A new method lor screening antidepressants in mice Psychopharmacol 85, 367370CrossRefGoogle Scholar
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Fluoxetine seems to widen the nortriptyline antidepressant-like dose range in mice submitted to the tail suspension test (TST)
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