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Effect of tianeptine on the hypothalamic control of the corticotropic response to stress

Published online by Cambridge University Press:  16 April 2020

V Guillaume ,
E Magnan ,
M Cataldi ,
F Héry ,
A Dutour ,
F Dadoun ,
L Mazzocchi ,
M Grino ,
B Conte-Devolx  and
C Oliver
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V Guillaume
Affiliation:
Laboratoire de Neuroendocrinologie Expérimentale, INSERM U 297, Faculté de Médecine Nord, boulevard Pierre Dramard, 13326Marseille Cedex 2020
E Magnan
Affiliation:
Laboratoire de Neuroendocrinologie Expérimentale, INSERM U 297, Faculté de Médecine Nord, boulevard Pierre Dramard, 13326Marseille Cedex 2020
M Cataldi*
Affiliation:
Laboratoire de Neuroendocrinologie Expérimentale, INSERM U 297, Faculté de Médecine Nord, boulevard Pierre Dramard, 13326Marseille Cedex 2020
F Héry
Affiliation:
Laboratoire de Neuroendocrinologie Expérimentale, INSERM U 297, Faculté de Médecine Nord, boulevard Pierre Dramard, 13326Marseille Cedex 2020
A Dutour
Affiliation:
Laboratoire de Neuroendocrinologie Expérimentale, INSERM U 297, Faculté de Médecine Nord, boulevard Pierre Dramard, 13326Marseille Cedex 2020
F Dadoun
Affiliation:
Laboratoire de Neuroendocrinologie Expérimentale, INSERM U 297, Faculté de Médecine Nord, boulevard Pierre Dramard, 13326Marseille Cedex 2020
L Mazzocchi
Affiliation:
Laboratoire de Neuroendocrinologie Expérimentale, INSERM U 297, Faculté de Médecine Nord, boulevard Pierre Dramard, 13326Marseille Cedex 2020
M Grino
Affiliation:
Laboratoire de Neuroendocrinologie Expérimentale, INSERM U 297, Faculté de Médecine Nord, boulevard Pierre Dramard, 13326Marseille Cedex 2020
B Conte-Devolx
Affiliation:
Laboratoire de Neuroendocrinologie Expérimentale, INSERM U 297, Faculté de Médecine Nord, boulevard Pierre Dramard, 13326Marseille Cedex 2020
C Oliver*
Affiliation:
Laboratoire de Neuroendocrinologie Expérimentale, INSERM U 297, Faculté de Médecine Nord, boulevard Pierre Dramard, 13326Marseille Cedex 2020
MC Rettori
Affiliation:
Institut de Recherches Internationales Servier, 6, place des Pléiades, 92415Courbevoie Cedex, France
E Mocaër
Affiliation:
Institut de Recherches Internationales Servier, 6, place des Pléiades, 92415Courbevoie Cedex, France
A Kamoun
Affiliation:
Institut de Recherches Internationales Servier, 6, place des Pléiades, 92415Courbevoie Cedex, France
*
*Present address: Istituto di Endocrinologia, IIa Facoltà di Medicina, Via S Pansini n°5, 80131 Naples, Italy.
*Present address: Istituto di Endocrinologia, IIa Facoltà di Medicina, Via S Pansini n°5, 80131 Naples, Italy.
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Summary

Stress-induced stimulation of corticotropic function involves the activation of hypothalamic corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP), which can be measured by improved methods of neuroendocrine investigation. The antiserotoninergic tricyclic antidepressant, tianeptine, reduces the corticotropic response to stress, as shown by a reduction in hypothalamo-hypophyseal portal CRH and AVP levels.

Keywords

stressCRHAVPtianeptine
Type
Research Article
Information
European Psychiatry , Volume 8 , Issue S2: Neuroendocrinological aspects of depression 28 June 1992, Nice, France , 1993 , pp. 55s - 60s
Copyright
Copyright © Elsevier, Paris 1993

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