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Disentangling early and late onset of psychosis in women

Published online by Cambridge University Press:  01 September 2022

A. Díaz-Pons ,
A. González-Rodríguez ,
V. Ortiz-García De La Foz ,
M. Seeman ,
C. Facorro  and
R. Ayesa-Arriola
A. Díaz-Pons*
Affiliation:
Valdecilla Biomedical Research Institute, Psychiatry, Santander, Spain
A. González-Rodríguez
Affiliation:
Mutua Terrassa University Hospital, Department Of Mental Health, Terrassa, Spain
V. Ortiz-García De La Foz
Affiliation:
Valdecilla Biomedical Research Institute, Psychiatry, Santander, Spain
M. Seeman
Affiliation:
University of Toronto, Department Of Psychiatry, Toronto, Canada
C. Facorro
Affiliation:
Hospital virgen del Rocio, Sevilla, Sevilla, Spain
R. Ayesa-Arriola
Affiliation:
Valdecilla Biomedical Research Institute, Psychiatry, Santander, Spain
*
*Corresponding author.

Abstract

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Introduction

Women present a second peak of incidence of psychosis during menopausal transition, partially explained by the loss of estrogen protection conferred during the reproductive years. Despite this, few studies compare sociodemographic, biological, clinical varibles and neurocognitive performance between women with early onset of psychosis (EOP) and those with late onset of psychosis (LOP).

Objectives

Our aim was to characterize both groups in a large sample of women, of which 294 were FEP patients (EOP = 205; LOP = 85) and 202 were healthy controls (HC) grouped following cutoff point (<>40 years of age) in previous studies.

Methods

Clinical and laboratory assessments were completed. Neurocognitive performance was also evaluated, and a cognitive global deficit score (GDS) was derived. ANCOVA was used for comparisons.

Results

EOP women were more frequently single and unemployed than comparable HC. Cholesterol levels in LOP women were higher than those of EOP women. LOP presented less severe symptoms, and higher scores in processing speed and premorbid IQ than EOP patients. Cannabis and alcohol use were also more frequent in EOP than LOP women.

Conclusions

Women with EOP and LOP show several sociodemographic, neuropsychological and clinical differences which may be valuable for planning personalized treatment emphasizing in socialization and differential generational dynamics. Some of these differences may be due to the aging process, while others might be influenced by factors such as lack of estrogen neuroprotection. In turn, drug consumption, low IQ and recent experienced trauma could as well reduce efficacy of hormonal neuroprotection.

Disclosure

No significant relationships.

Keywords

First Episode PsychosiswomenEarly onset psychosisLate onset psychosis
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S356
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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