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Cortisol Response To Interpersonal Stress in Young Adults With Borderline Personality Disorder: A Pilot Study

Published online by Cambridge University Press:  06 March 2008

Marc Walter ,
Jean-François Bureau ,
Bjarne M. Holmes ,
Eszter A. Bertha ,
Michael Hollander ,
Joan Wheelis ,
Nancy Hall Brooks  and
Karlen Lyons-Ruth
Marc Walter*
Affiliation:
Department of Psychiatry, University of Basel, Wilhelm Klein-Strasse 27, CH-4025Basel, Switzerland Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA
Jean-François Bureau
Affiliation:
Department of Psychiatry, Cambridge Hospital, Harvard Medical School, Cambridge, MA, USA
Bjarne M. Holmes
Affiliation:
Department of Psychiatry, Cambridge Hospital, Harvard Medical School, Cambridge, MA, USA School of Life Sciences, Heriot-Watt University, UK
Eszter A. Bertha
Affiliation:
Department of Psychiatry, Cambridge Hospital, Harvard Medical School, Cambridge, MA, USA
Michael Hollander
Affiliation:
Two Brattle Center, Cambridge, MA, USA
Joan Wheelis
Affiliation:
Two Brattle Center, Cambridge, MA, USA
Nancy Hall Brooks
Affiliation:
Department of Psychiatry, Cambridge Hospital, Harvard Medical School, Cambridge, MA, USA
Karlen Lyons-Ruth
Affiliation:
Department of Psychiatry, Cambridge Hospital, Harvard Medical School, Cambridge, MA, USA
*
∗Corresponding author. Department of Psychiatry, University of Basel, Wilhelm Klein-Strasse 27, CH-4025 Basel, Switzerland. E-mail address: marc.walter@upkbs.ch (M. Walter).
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Abstract

Hypothalamic–pituitary–adrenal axis dysregulation after stress was found to be associated with borderline personality disorder (BPD). Nine female BPD young adults and 12 control subjects were investigated for stress reactivity and recovery after an interpersonal conflict discussion with their mothers. BPD subjects showed a delayed cortisol response after psychosocial stress.

Keywords

Borderline personality disorderPsychosocial stressCortisol response
Type
Short communication
Information
European Psychiatry , Volume 23 , Issue 3 , April 2008 , pp. 201 - 204
Copyright
Copyright © European Psychiatric Association 2008

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References

Carlson, E.B., Putnam, F.W., Ross, C.A., Torem, M., Coons, P., Dill, D.L.et al.Validity of the Dissociative Experience Scale in screening for multiple personality disorder: a multicenter study. Am J Psychiatry 1993;150:1030–1036.Google Scholar
Dickerson, S.S., Kemeny, M.E.Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Psychol Bull 2004;130:355–391.CrossRefGoogle ScholarPubMed
Dressendoerfer, R.A., Kirschbaum, C., Rohde, W., Stahl, F., Strasburger, C.J.Synthesis of a cortisol-biotin conjugate and evaluation as tracer in an imunoassay for salivary cortisol measurement. J Steroid Biochem Mol Biol 1990;43:683–692.CrossRefGoogle Scholar
First, M.B., Spitzer, R.L., Gibbon, M., William, J.B.W.Structured clinical interview for DSM-IV Axis I disorders/patient edition (SCID-I/P). New York: New York State Psychiatric Institute, Biometrics Research Department; 1996.Google Scholar
First, M.B., Gibbon, M., Spitzer, R.L., Williams, J.B.W., Benjamin, L.Structured clinical interview for DSM-IV personality disorders (SCID-II): interview and questionnaire. Washington, DC: American Psychiatric Press; 1997.Google Scholar
Gunderson, J.G., Shea, M.T., Skodol, A.E., McGlashan, T.H., Morey, L.C., Stout, B.et al.The Collaborative Longitudinal Personality Disorders Study: development, aims, design, and sample characteristics. J Personal Disord 2000;14:300–315.CrossRefGoogle ScholarPubMed
Gunderson, J.G.Borderline personality disorder: a clinical guide. Washington, DC: American Psychiatric Press; 2001.Google Scholar
Gunderson, JG, Lyons-Ruth, K.BPD's interpersonal hypersensitive phenotype: a gene-environment transactional model. J Personal Disord, in press.Google Scholar
Grossman, R., Yehuda, R., New, A., Schmeidler, J., Silverman, J., Mitropoulou, V.et al.Dexamethasone suppression test findings in subjects with personality disorders: associations with posttraumatic stress disorder and depression. Am J Psychiatry 2003;160:1291–1297.CrossRefGoogle ScholarPubMed
Hertsgaard, L., Gunnar, M., Erickson, M.F., Nachmius, M.Adrenocortical response to the strange situation in infants with disorganized/disoriented attachment relationships. Child Dev 1995;66:1100–1106.CrossRefGoogle Scholar
Jogems-Kosterman, B.J., de Knijff, D.W., Kusters, R., van Hoof, J.J.Basal cortisol and DHEA levels in women with borderline personality disorder. J Psychiatr Res 2006;41:1019–1026.CrossRefGoogle ScholarPubMed
Klimes-Dougan, B., Hastings, P.D., Granger, D.A., Usher, B.A., Zahn-Waxler, C.Adrenocortical activity in at-risk and normally developing adolescents: individual differences in salivary cortisol basal levels, diurnal variation, and responses to social challenges. Dev Psychopathol 2001;13:695–719.CrossRefGoogle ScholarPubMed
Kobak, R.R., Cole, H.E., Ferenz-Gillies, R., Fleming, W.S., Gamble, W.Attachment and emotion regulation during mother-teen problem solving: a control theory analysis. Child Dev 1993;64:231–245.CrossRefGoogle ScholarPubMed
Korzekwa, M., Steiner, M., Links, P., Eppel, A.The dexamethasone suppression test in borderlines: is it useful?. Can J Psychiatry 1991;36:26–28.CrossRefGoogle ScholarPubMed
Lange, W., Wulff, H., Berea, C., Beblo, T., Saavedra, A.S., Mensebach, C.et al.Dexamethasone suppression test in borderline personality disorder – effects of posttraumatic stress disorder. Psychoneuroendocrinology 2005;30:919–923.CrossRefGoogle ScholarPubMed
Lieb, K., Rexhausen, J.E., Kahl, K.G., Schweiger, U., Philipsen, A., Hellhammer, D.H.et al.Increased diurnal salivary cortisol in women with borderline personality disorder. J Psychiatry Res 2004;38:559–565.CrossRefGoogle ScholarPubMed
Linehan, M.M.Cognitive-behavioral treatment in borderline personality disorder. New York: Guilford Press; 1993.Google Scholar
Pagano, M.E., Skodol, A.E., Stout, R.L., Shea, M.T., Yen, S., Grilo, C.M.et al.Stressful life events as predictors of functioning: findings from the Collaborative Longitudinal Personality Disorders Study. Acta Psychiatr Scand 2004;110:421–429.CrossRefGoogle ScholarPubMed
Powers, S.I., McArdle, E.T.Coping strategies moderate the relation of the hypothalamic–pituitary–adrenal axis reactivity to self-injurious behavior. Ann N Y Acad Sci 2003;1008:285–288.CrossRefGoogle Scholar
Radloff, L.S.The CES-D scale: a self-report depression scale for research in the general population. Appl Psych Meas 1977;1:385–401.CrossRefGoogle Scholar
Rinne, T., de Kloet, E.R., Wouters, L., Goekoop, J.G., DeRijk, R.H., van den Brink, W.Hyperresponsiveness of hypothalamic–pituitary–adrenal axis to combined dexamethasone/corticotropin-releasing hormone challenge in female borderline personality disorder subjects with a history of sustained childhood abuse. Biol Psychiatry 2002;52:1102–1112.CrossRefGoogle ScholarPubMed
Simeon, D., Knutelska, M., Smith, L., Baker, B.B., Hollander, E.A preliminary study of cortisol and norepinephrine reactivity to psychosocial stress in borderline personality disorder with high and low dissociation. Psychiatry Res 2007;149:177–184.CrossRefGoogle ScholarPubMed
Spangler, G., Grossmann, K.E.Biobehavioral organization in securely and insecurely attached infants. Child Dev 1993;64:1439–1450.CrossRefGoogle ScholarPubMed
Straus, M.A.Measuring intrafamily conflict and violence: the conflict tactics scales. J Marriage Fam 1979;41:75–88.CrossRefGoogle Scholar
Torgersen, S., Kringlen, E., Cramer, V.The prevalence of personality disorders in a community sample. Arch Gen Psychiatry 2001;58:590–596.CrossRefGoogle Scholar
Walter, M., Gerhard, U., Gerlach, M., Weijers, H.-G., Boening, J., Wiesbeck, G.A.Cortisol concentrations, stress-coping styles after withdrawal, and long-term abstinence in alcohol dependence. Addict Biol 2006;54:100–106.Google Scholar
Wingenfeld, K., Driessen, M., Adam, B., Hill, A.Overnight urinary cortisol release in women with borderline personality disorder depends on comorbid PTSD and depressive psychopathology. Eur Psychiatry 2007;22:309–312.CrossRefGoogle ScholarPubMed
Zweig-Frank, H., Paris, J., Ng Ying Kin, N.M.K., Schwartz, G., Steiger, H., Nair, N.P.V.Childhood sexual abuse in relation to neurobiological challenge tests in patients with borderline personality disorder and normal controls. Psychiatry Res 2006;141:337–341.CrossRefGoogle ScholarPubMed
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