Hostname: page-component-8448b6f56d-qsmjn Total loading time: 0 Render date: 2024-04-19T14:24:03.989Z Has data issue: false hasContentIssue false
  • English
  • Français

Brain Perfusion Characterizes First Episode of Psychosis Patients in Respect to Healthy Controls.

Published online by Cambridge University Press:  15 April 2020

L. Squarcina ,
C. Perlini ,
D. Peruzzo ,
U. Castellani ,
V. Marinelli ,
M. Bellani ,
G. Rambaldelli ,
A. Lasalvia ,
S. Tosato  and
K. De Santi
...Show all authors
L. Squarcina
Affiliation:
Department of Public Health and Community Medicine Section of Psychiatry, AOUI Verona, Verona, Italy
C. Perlini
Affiliation:
Department of Public Health and Community Medicine Section of Psychiatry, AOUI Verona, Verona, Italy
D. Peruzzo
Affiliation:
Department of Informatics, University of Verona, Verona, Italy
U. Castellani
Affiliation:
Department of Informatics, University of Verona, Verona, Italy
V. Marinelli
Affiliation:
Department of Public Health and Community Medicine Section of Psychiatry, AOUI Verona, Verona, Italy
M. Bellani
Affiliation:
Department of Public Health and Community Medicine Section of Psychiatry, AOUI Verona, Verona, Italy
G. Rambaldelli
Affiliation:
Department of Public Health and Community Medicine Section of Psychiatry, AOUI Verona, Verona, Italy
A. Lasalvia
Affiliation:
Department of Public Health and Community Medicine Section of Psychiatry, AOUI Verona, Verona, Italy
S. Tosato
Affiliation:
Department of Public Health and Community Medicine Section of Psychiatry, AOUI Verona, Verona, Italy
K. De Santi
Affiliation:
Department of Public Health and Community Medicine Section of Psychiatry, AOUI Verona, Verona, Italy
F. Spagnolli
Affiliation:
Department of Morphological and Biomedical Sciences Section of Radiology, University of Verona, Verona, Italy
N. Cardobi
Affiliation:
Department of Morphological and Biomedical Sciences Section of Radiology, University of Verona, Verona, Italy
R. Cerini
Affiliation:
Department of Morphological and Biomedical Sciences Section of Radiology, University of Verona, Verona, Italy
M. Ruggeri
Affiliation:
Department of Public Health and Community Medicine Section of Psychiatry, AOUI Verona, Verona, Italy
P. Brambilla
Affiliation:
5Department of Experimental & Clinical Medical Sciences, University of Udine, Verona, Italy

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Introduction

Vascular changes in the brain are relevant in schizophrenia [e.g. 1] and in bipolar disorder [2]. The study of first episode psychosis (FEP) allows the analysis of brain morphology and function without confounds due to chronicity.

Objectives

To characterize brain perfusion in FEP.

Aims

To see if FEP exhibit modified perfusion in respect to healthy controls (HC), and identify the most affected brain areas.

Methods

We acquired T1 and DSC images of 35 FEP patients (45 +/- 10 years old) and 35 HC (42 +/- 8), using Gadolinium (0.1 mmol/Kg). We computed cerebral blood volume (CBV), cerebral blood flow (CBF) and mean transit time (MTT) [3] in the whole brain and in left and right frontal, parietal, temporal and occipital lobes, insula, caudate and cerebellum

Results

Mean values of all quantities resulted lower in patients, up to 12% for CBV in right frontal lobe, 11% for CBF in left cerebellum and 16% for MTT in right frontal lobe. We used a support vector machine (SVM) to classify subjects on the basis of the histogram of perfusion values. We found that the classification reached accuracies over 80%, especially in the frontal brain areas.

Conclusions

FEP show altered perfusion parameters, which allow automatic classification with good accuracy, showing that brain vascular characteristics can be considered as marker of psychosis.

  1. [1] Peruzzo et al (2011). J Neural Transm, 118, 4:563-70.

  2. [2] Agarwal et al (2008). J Affect Disord, 110, 1-2:106-14.

  3. [3] Ostergaard et al (1996). Magn Reson Med, 36, 5:715-25.

Type
Article: 0302
Information
European Psychiatry , Volume 30 , Issue S1: Abstracts of the 23rd European Congress of Psychiatry , March 2015 , pp. 1
Copyright
Copyright © European Psychiatric Association 2015

References

Peruzzo, , et al.J Neural Transm 2011; 118(4): 563–57010.1007/s00702-010-0548-7CrossRefGoogle Scholar
Agarwal, , et al.J Affect Disord 110 (1–2) 2008 106–11410.1016/j.jad.2008.01.013CrossRefGoogle Scholar
Ostergaard, , et al.Magn Reson Med 1996; 36(5): 715–72510.1002/mrm.1910360510CrossRefGoogle Scholar
Submit a response

Comments

No Comments have been published for this article.