Hostname: page-component-7c8c6479df-fqc5m Total loading time: 0 Render date: 2024-03-19T02:57:34.750Z Has data issue: false hasContentIssue false

Baseline, Two-year, and Five-year Follow-up of Children and Adolescents with First-episode Psychosis: A Spanish Cohort

Published online by Cambridge University Press:  23 March 2020

J. Janssen
Affiliation:
Hospital General Universitario Gregorio Marañón- School of Medicine- Universidad Complutense- IiSGM- CIBERSAM, Child and Adolescent Psychiatry, Madrid, Spain Brain Center Rudolf Magnus- University Medical Center Utrecht, Psychiatry, Utrecht, The Netherlands
H. Schnack
Affiliation:
Brain Center Rudolf Magnus- University Medical Center Utrecht, Psychiatry, Utrecht, The Netherlands
K. Martínez
Affiliation:
Hospital General Universitario Gregorio Marañón- School of Medicine- Universidad Complutense- IiSGM- CIBERSAM, Child and Adolescent Psychiatry, Madrid, Spain
J. Santonja
Affiliation:
Hospital General Universitario Gregorio Marañón- School of Medicine- Universidad Complutense- IiSGM- CIBERSAM, Child and Adolescent Psychiatry, Madrid, Spain
Y. Aleman-Gomez
Affiliation:
IISGM- Hospital Universitario Gregorio Maranon, Experimental Medicine and Surgery, Madrid, Spain
L. Pina-Camacho
Affiliation:
Hospital General Universitario Gregorio Marañón- School of Medicine- Universidad Complutense- IiSGM- CIBERSAM, Child and Adolescent Psychiatry, Madrid, Spain
D. Fraguas
Affiliation:
Hospital General Universitario Gregorio Marañón- School of Medicine- Universidad Complutense- IiSGM- CIBERSAM, Child and Adolescent Psychiatry, Madrid, Spain
C. Moreno
Affiliation:
Hospital General Universitario Gregorio Marañón- School of Medicine- Universidad Complutense- IiSGM- CIBERSAM, Child and Adolescent Psychiatry, Madrid, Spain
C. Arango
Affiliation:
Hospital General Universitario Gregorio Marañón- School of Medicine- Universidad Complutense- IiSGM- CIBERSAM, Child and Adolescent Psychiatry, Madrid, Spain
M. Parellada
Affiliation:
Hospital General Universitario Gregorio Marañón- School of Medicine- Universidad Complutense- IiSGM- CIBERSAM, Child and Adolescent Psychiatry, Madrid, Spain

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Background

Early-onset first-episode psychosis (FEP) and high functioning autism spectrum disorders (ASD) are complex neuro–developmental disorders that share symptomatology but it is not clear if they also share neurobiological abnormalities (Chisholm et al., 2015). We examined thickness, surface area and volume in a direct comparison of children and adolescents with FEP (onset before 18 years), high-functioning ASD, and healthy subjects.

Methods

Magnetic resonance imaging scans of 85 participants (30 ASD, 29 FEP, 26 healthy controls, age range 10–18 years) were obtained from the same MR scanner using the same acquisition protocol. The FreeSurfer analysis suite was used to quantify vertex-wise estimates of the metrics thickness, surface area, and volume.

Results

ASD and FEP had spatially overlapping insular deficits for each metric. The transdiagnostic overlap of deficits was greatest for volume (55% of all insular vertices) and smallest for thickness (18%). Insular thickness and surface area deficits did not overlap in ASD and overlapped only in 8% of all insular vertices in FEP.

Conclusions

Morphological insular deficits are common to FEP and high functioning ASD when compared to healthy participants. The pattern of deficits was similar in both disorders, i.e. a largely non-overlap of insular thickness and surface area. The non-overlap provides further evidence that these metrics represent two independent outcomes of corticogenesis, both of which are affected in FEP and ASD.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
Workshop: brain changes in early onset psychosis
Copyright
Copyright © European Psychiatric Association 2017
Submit a response

Comments

No Comments have been published for this article.