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P0362 - Distinct language dimensions correlate with superior temporal gyrus and Heschl's gyrus in schizophrenia and healthy controls

Published online by Cambridge University Press:  16 April 2020

C. Perlini ,
S. Sponda ,
A. Tavano ,
F. Fabbro ,
A. Ferro ,
S. Cerruti ,
G. Rambaldelli ,
R. Cerini ,
M. Tansella  and
P. Brambilla
C. Perlini
Affiliation:
Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy Verona-Udine Brain Imaging and Neuropsychology Program, Inter-University Center for Behavioral Neurosciences, University of Verona, Verona, Italy and University of Udine, Udine, Italy
S. Sponda
Affiliation:
Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy Verona-Udine Brain Imaging and Neuropsychology Program, Inter-University Center for Behavioral Neurosciences, University of Verona, Verona, Italy and University of Udine, Udine, Italy
A. Tavano
Affiliation:
Scientific Institute E. Medea, Udine, Italy
F. Fabbro
Affiliation:
Scientific Institute E. Medea, Udine, Italy
A. Ferro
Affiliation:
Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy Verona-Udine Brain Imaging and Neuropsychology Program, Inter-University Center for Behavioral Neurosciences, University of Verona, Verona, Italy and University of Udine, Udine, Italy
S. Cerruti
Affiliation:
Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy Verona-Udine Brain Imaging and Neuropsychology Program, Inter-University Center for Behavioral Neurosciences, University of Verona, Verona, Italy and University of Udine, Udine, Italy
G. Rambaldelli
Affiliation:
Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy Verona-Udine Brain Imaging and Neuropsychology Program, Inter-University Center for Behavioral Neurosciences, University of Verona, Verona, Italy and University of Udine, Udine, Italy
R. Cerini
Affiliation:
Department of Morphological and Biomedical Sciences, Section of Radiology, University of Verona, Verona, Italy
M. Tansella
Affiliation:
Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy Verona-Udine Brain Imaging and Neuropsychology Program, Inter-University Center for Behavioral Neurosciences, University of Verona, Verona, Italy and University of Udine, Udine, Italy
P. Brambilla
Affiliation:
Verona-Udine Brain Imaging and Neuropsychology Program, Inter-University Center for Behavioral Neurosciences, University of Verona, Verona, Italy and University of Udine, Udine, Italy Department of Pathology and Clinical and Experimental Medicine, Section of Psychiatry, University of Udine, Udine, Italy

Abstract

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Background and Aims:

Language disturbances, such as impoverishment, disorganization and dysregulation, are a prominent feature of schizophrenia. Several neuroimaging studies have suggested the superior temporal gyrus (STG) as a likely anatomical substrate of language deficits in schizophrenia. The aim of this study was to verify a correlation between structural measures of STG and Heschl's gyrus (HG) and language dimensions.

Methods:

An extensive language examination battery, which included narrative and conversational expressive tasks, and syntactic and pragmatic comprehension tests, was administered to 23 schizophrenia patients (mean age±SD= 40.30±11.60) and 21 normal controls (mean age±SD= 42.19±11.05). All subjects also underwent a 1.5T MRI session, and STG and HG were manually traced and volumes were obtained, bilaterally, using Brains2.

Results:

Specific language deficits were shown in subjects with schizophrenia compared to healthy individuals (p<0.001), particularly in verbal fluency, syntactic complexity, lexical diversity and metaphor/idiom comprehension. Interestingly, speech fluency significantly directly associated with left STG gray matter volumes in controls (r=0.46, p=0.03) but not in patients (r=-0.27, p=0.21). In contrast, complex syntax and word diversity significantly correlated, respectively, with left and right HG volumes in schizophrenia patients (r=0.45, p=0.02; r=-0.47, p=0.02), but not in controls (p>0.05).

Conclusions:

This study confirmed a widespread impairment of language in schizophrenia. Interestingly, distinct language dimensions differently correlated with STG-HG volumes in patients with schizophrenia and controls, particularly with regard to verbal fluency and syntactic measures.

Type
Poster Session I: Brain Imaging
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S188
Copyright
Copyright © European Psychiatric Association 2008
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