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The influence of ethanol infusion on the effects of 35% CO2 challenge. A study in panic disorder patients and healthy volunteers

Published online by Cambridge University Press:  16 April 2020

F. Cosci
Affiliation:
Dipartimento di Scienze Neurologiche e Psichiatriche, Viale Morgagni, 85, 50134Florence, Italy
T. De Gooyer
Affiliation:
Department of Psychiatry and Neuropsychology, Maastricht University, P.O. Box 616, MaastrichtMD 6200, The Netherlands
K. Schruers
Affiliation:
Department of Psychiatry and Neuropsychology, Maastricht University, P.O. Box 616, MaastrichtMD 6200, The Netherlands
C. Faravelli
Affiliation:
Dipartimento di Scienze Neurologiche e Psichiatriche, Viale Morgagni, 85, 50134Florence, Italy
E. Griez
Affiliation:
Department of Psychiatry and Neuropsychology, Maastricht University, P.O. Box 616, MaastrichtMD 6200, The Netherlands
Corresponding
E-mail address:
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Abstract

Alcohol and panic disorders co-occur at a rate that exceeds chance significantly. Early experimental work suggests that alcoholic subjects, compared to non-alcoholics, are less sensitive to sodium lactate and that alcohol intake reduces the response to a 35% CO2 challenge in Panic Disorder patients. The present study documents the direct pharmacological effect of ethanol infusion on CO2 induced panic.

Methods

According to a placebo-controlled, double-blind, randomized, cross-over design 10 drug free panic disorder patients and 16 healthy volunteers underwent a 35% CO2 challenge after intravenous infusion of a moderate dose of ethanol on one test day and of placebo on another test day.

Results

Compared to the placebo condition, the effect of the CO2 challenge was significantly smaller after ethanol infusion (P = 0.041).

Discussion

A moderate dose of ethanol decreased the response to a 35% CO2 without inducing pre challenge sedation.

Conclusion

The results comfort earlier findings of a direct pharmacological effect of ethanol on panic.

Type
Original article
Copyright
Copyright © Elsevier SAS 2005

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