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1666 – The Burden Of Accelerated Ageing In Schizophrenia

Published online by Cambridge University Press:  15 April 2020

D. Cohen  and
A. Nugter
D. Cohen
Affiliation:
Severe Mental Illness, Mental Health Organization North-Holland North, Heerhugowaard Clinical Epidemiology, University of Groningen, Groningen, The Netherlands
A. Nugter
Affiliation:
Severe Mental Illness, Mental Health Organization North-Holland North, Heerhugowaard

Abstract

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Introduction

Among patients with schizophrenia there is a significant increased prevalence of type 2 diabetes mellitus. In addition, schizophrenia is accompanied by 15–32 years reduced life-expectancy. We hypothesize a contribution from accelerated ageing.

Objectives

To compare Autofluorescence (AF) levels of patients with severe mental illness (SMI) with the general population.

Aims

To test to what extent accelerated ageing is specific for patients with schizophrenia.

Method

Outpatients with SMI were asked to participate. AF levels were measured with the AGE-reader. Patients with diabetic mellitus were excluded from the analyses.

Results

[Mean AF values in study-population (N=122)]

Age-cohortsGeneral PopulationSMI-populationt-valueSize Study Population
20–29 years1.532.175.95***N=11
30–39 years1.732.2110.20***N=30
40–49 years1.812.317.85***N=43
50–59 years2.092.857.03***N=24
60–69 years2.462.8252.44*N=14
*

p< .05

***

p< .001

Of the 154 patients who were asked to participate 70,8% were male, 74,3% suffered from schizophrenia, 15,3% from diabetes mellitus and of 3% the skin was too dark for a reliable assessment. Only 5 patients refused to participate.

A regression analysis with age as single predictor, confirmed the predictive value of age. Compared to the general population (R2 = .60), the explained variance of R2=.23, p< .001 in the study population is low. Addition of duration of treatment or psychiatric diagnosis as predictors did not change the outcome.

Conclusion

AF-values indicate that accelerated ageing is present in patients with SMI.

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E943
Copyright
Copyright © European Psychiatric Association 2013
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