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Reducción de la inhibición de la respuesta en el trastorno obsesivo compulsivo

Published online by Cambridge University Press:  12 May 2020

R. Penadés ,
R. Catalán ,
K. Rubia ,
S. Andrés ,
M. Salamero  and
C. Gastó
R. Penadés
Affiliation:
Instituto de Neurociencia Clínica, Hospital Clínico, Villarroel 170, 08036Barcelona, España
R. Catalán
Affiliation:
Instituto de Neurociencia Clínica, Hospital Clínico, Villarroel 170, 08036Barcelona, España
K. Rubia
Affiliation:
Instituto de Psiquiatría, King’s College, Londres, Reino Unido
S. Andrés
Affiliation:
Instituto de Neurociencia Clínica, Hospital Clínico, Villarroel 170, 08036Barcelona, España
M. Salamero
Affiliation:
Instituto de Neurociencia Clínica, Hospital Clínico, Villarroel 170, 08036Barcelona, España
C. Gastó
Affiliation:
Instituto de Neurociencia Clínica, Hospital Clínico, Villarroel 170, 08036Barcelona, España
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Resumen

Objetivo

Este estudio investiga tres funciones de control inhibidoras diferentes en pacientes con trastorno obsesivo compulsivo (TOC). La inhibición selectiva de la respuesta motora se investigó con un paradigma GO/NO-GO, la inhibición de una respuesta motora desencadenada con el paradigma STOP y la capacidad de inhibir la interferencia cognitiva con el paradigma motor STROOP.

Métodos

Se aplicaron los tests GO/NO-GO (ejecución-no ejecución), STOP y STROOP a 27 pacientes que cumplieron los criterios del DSM-IV para TOC y 25 sujetos de control sanos apareados por edad, lateralidad y CI.

Resultados

Los pacientes con TOC tuvieron un rendimiento significativamente peor que los controles en la inhibición selectiva de las respuestas (GO/NO-GO) y en la inhibición de la interferencia cognitiva (STROOP) y también tuvieron peor rendimiento en la inhibición de respuestas motoras previamente desencadenadas (STOP).

Conclusiones

Los pacientes con TOC tienen deficiencias en los mecanismos inhibidores motores y cognitivos. Los resultados coinciden con los modelos psicobiológicos y neuropsicológicos de TOC que sugieren que existe un deterioro en los circuitos frontoestriatales que regulan las funciones de control inhibidor.

Keywords

Trastorno obsesivo compulsivoTarea GO/NO-GOTarea STOPTarea STROOPInhibición cognitivaInhibición de la respuesta motora
Type
Artículo original
Information
European Psychiatry (Ed. Española) , Volume 14 , Issue 8 , November 2007 , pp. 400 - 407
Copyright
Copyright © European Psychiatric Association 2007

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References

Bibliografía

American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: Author; 1994.Google Scholar
Band, GPVan der Molen, MWLogan, GDHorse-race model simulations of the stop-signal procedure. Acta Psychol 2003;112(2):105–42.CrossRefGoogle ScholarPubMed
Banich, MTMilham, MPAtchley, RCohen, NJWebb, AWszalek, Tet al. fMRI studies of Stroop tasks reveal unique roles of anterior and posterior brain systems in attentional selection. J Cognitive Neurosci 2000;12:988–1000.CrossRefGoogle ScholarPubMed
Bannon, SGonsalvez, CJCroft, RJBoyce, PMResponse inhibition deficits in obsessive-compulsive disorder. Psychiatry Res 2002;110: 165–74.CrossRefGoogle ScholarPubMed
Baxter, LEPhelps, EAMazziotta, JCGuze, BHSchwartz, JMSelin, CELocal cerebral glucose metabolic rates in obsessive-compulsive disorder: a comparison with rates in unipolar depression in normal Controls. Arch Gen Psychiat 1987;44:211–8.CrossRefGoogle ScholarPubMed
Baxter, LESchwartz, JMMazziotta, JCPhelps, MEPahl, JJGuze, BHet al. Cerebral glucose metabolic rates in non-depressed obsessive-compulsives. Am J Psychiatry 1988;145:1560–3.Google Scholar
Baxter, LRAckermann, RFSwerdlow, NRBrody, ASaxena, SScwartz, JMet al. Specific brain system mediation of obsessivecompulsive disorder responsive to either medication or behavior therapy. In: Goodman, WKRudorfer, MV editors. Obsessive-compulsive disorder: contemporary issues in treatment. Mahway, NJ: Lawrence Erlbaum Associates, Inc. Black, H.; 2000. p. 573–609.Google Scholar
Beck, ATWard, CHMendelson, MErbaugh, JAn inventory for measuring depression. Arch Gen Psychiat 1961;4:561–71.CrossRefGoogle ScholarPubMed
Berthier, MLKulisevsky, JJGironell, ALopez, OLObsessive compulsive disorder and traumatic brain injury: behavioral, cognitive, and neuroimaging findings. Neuropsychiatry Neuropsychol Behav Neurol 2001;14:23–31.Google ScholarPubMed
Breiter, HCRauch, SLFunctional MRI and the study of OCD: from symptom provocation to cognitive-behavioral probes of corticostriatal systems and the amygdala. NeuroImage 1996;4:S127-38.CrossRefGoogle Scholar
Cavedini, PFerri, SScarone, SBellodi, LFrontal lobe dysfunction in obsessive-compulsive disorder and major depression: a clinical-neuropsychological study. Psychiatry Res 1998;78:21–8.CrossRefGoogle ScholarPubMed
Chamberlain, SRBlackwell, ADFineberg, BARobbins, TWSahakian, BJThe neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers. Neurosci Biobehav Rev 2005; 29:399–419.CrossRefGoogle ScholarPubMed
Clayton, ICRichards, JCEdwards, CJSelective attention in obsessive-compulsive disorder. J Abnorm Psychol 1999;108:171–5.CrossRefGoogle ScholarPubMed
Cohen, YRasic, JLachenmeyer, ISpringer, CAnxiety and selective attention in obsessive-compulsive disorder. Behav Res Ther 2003;11:1311–23.CrossRefGoogle Scholar
Deckersbach, TOtto, MWSavage, CRBaer, LJenike, MAThe relationship between semantic organization and memory in obsessive compulsive disorder. Psychother Psychosom 2000;69:101–7.Google ScholarPubMed
Deckersbach, TSavage, CRHenin, AMataix-Cols, DOtto, MWWilhem, Set al. Reliability and validity of a scoring system approach in the complex figure test. J Clin Exp Neuropsyc 2000;22:640–8.CrossRefGoogle ScholarPubMed
Foa, EIlai, DMccarthy, PRShoyer, BMurdock, TInformation-processing in obsessive-compulsive disorder. Cognit Ther Res 1993;17:173-89.CrossRefGoogle Scholar
Gambini, OAbbruzesse, MScarone, SSmooth pursuit and saccadic eye movements and Wisconsin Card Sorting Test performance in obsessive-compulsive disorder. Psychiatry Res 1993;48:191–200.CrossRefGoogle ScholarPubMed
Hartston, HJSwerdlow, NRVisuospatial priming and Stroop performance in patients with obsessive compulsive disorder. Neuropsychology 1999;13:447–57.CrossRefGoogle ScholarPubMed
Herrman, MJJacob, CUnterecker, SFallgater, JAReduced response inhibition in obsessive-compulsive disorder measured with topographic evoked potential mapping. Psychiatry Res 2003;120:265–71.CrossRefGoogle Scholar
Johannes, SWieringa, BNMantey, MNager, WRada, DMüller-Valh, KRet al. Altered inhibition of motor responses in Tourette Syndrome and Obsessive-Compulsive Disorder. Acta Neurol Scand 2001;104:36–43.CrossRefGoogle ScholarPubMed
Karadag, FOguzhanoglu, NKKurt, TOguzhanoglu, AAtesci, FOzdel, OQuantitative EEG analysis in obsessive compulsive disorder. Int J Neurosci 2003;113:833–47.CrossRefGoogle ScholarPubMed
Kawashima, RSatoh, KMIoth, HOno, SFurumoto, SGotoh, Ret al. Functional anatomy of GO/NO-GO discrimination and response selection-a PET study in man. Brain Res 1996;728:79–89.Google ScholarPubMed
Kim, MSKang, SSYoun, TKang, DHKim, JJKwon, JSNeuropsychological correlates of P300 abnormalities in patients with schizophrenia and obsessive-compulsive disorder. Psychiatry Res 2003;123:109–23.CrossRefGoogle ScholarPubMed
Konishi, SNakajima, KUchida, IKikyo, HMiyashita, YCommon inhibitory mechanism in human inferior prefrontal cortex revealed by event-related functional MRI. Brain 1999;122:981–91.CrossRefGoogle ScholarPubMed
Konishi, SNakajima, KUchida, ISekihara, KMiyashita, YNo-go dominant brain activity in human inferior prefrontal cortex revealed by functional magnetic resonance imaging. Eur J Neurosci 1998;10:1209–13.CrossRefGoogle ScholarPubMed
Kwon, JSKim, JJLee, DWLee, JSLee, DSKim, MSet al. Neural correlates of clinical symptoms and cognitive dysfunctions in obsessive-compulsive disorder. Psychiatry Res-Neuroim 2003;122:37–47.CrossRefGoogle ScholarPubMed
Lacerda, ADalgalarrondo, PCaetano, DHaas, GLCamargo, EEKeshavan, MSNeuropsychological performance and regional cerebral blood flow in obsessive-compulsive disorder. Prog Neuro-Psychoph 2003;27:657–65.CrossRefGoogle ScholarPubMed
Leckman, JFMayes, LCUnderstanding developmental psychopath hology: how useful are evolutionary accounts? J Am Acad ChildPsy 1998;37:1011–21.CrossRefGoogle Scholar
Logan, GDSchachar, RTannock, RTImpulsivity and inhibitory control. Psychol Sci 1997;8:60–4.CrossRefGoogle Scholar
Lucey, JVCosta, DCBusatto, GPilowsky, LSMarks, IMEll, PJet al. Caudate regional cerebral blood flow in obsessive-compulsive disorder, panic disorder and healthy controls on single photon emission computerised tomography. Psychiatry Res Mar 1997;14:25–33.CrossRefGoogle Scholar
Macleod, CMMacdonald, PAThe Stroop effect and attention. Trends Neurosci 2000;4:383–91.CrossRefGoogle ScholarPubMed
Mataix-Cols, DAlonso, PMenchon, JMVallejo, JNeuropsychological performance in medicated vs. unmedicated patients with obsessive-compulsive disorder. Psychiatry Res 2002;109:255–6.CrossRefGoogle ScholarPubMed
Mavrogiorgou, PJuckel, GFrodl, TGallinat, JHauke, WZaudig, Met al. P300 subcomponents in obsessive-compulsive disorder. J Psychiat Res 2002;36:399–406.CrossRefGoogle ScholarPubMed
Milliery, MBouvard, MAupetit, JCottraux, JSustained attention in patients with obsessive-compulsive disorder: a controlled study. Psychiatry Res 2000;96:199–209.CrossRefGoogle ScholarPubMed
Oades, RDStimulus dimension shifts in patients with schizophrenia, with and without paranoid hallucinatory symptoms, or obsessive compulsive disorder: strategies, blocking and monoamine status. Behav Brain Res 1997;88:115–31.CrossRefGoogle ScholarPubMed
Okasha, ARaafat, MMahallawy, NEl Nahas, GSeif El Dawla, ASayed, Met al. Cognitive dysfunction in obsessive-compulsive disorder. Acta Psychiatr Scand 2000;101:281–5.Google ScholarPubMed
Purcell, RMaruff, PPantelis, CCognitive deficits in obsessive-compulsive disorder on tests of frontal-striatal function. Biol Psychiatry 1998;43:348–57.CrossRefGoogle ScholarPubMed
Purcell, RMaruff, PPantelis, CNeuropsychological deficits in obsessive compulsive disorder: a comparison with unipolar depression, panic disorder, and normal controls. Arch Gen Psychiat 1998;55:415–23.Google ScholarPubMed
Rachman, SHodgson, RObsessions and compulsions. New York: Prentice Hall; 1980.Google Scholar
Rosenberg, DRAverbach, DHO'Hearn, KM, Seymour, ABBirmaher, BSweeney, JAOculomotor response inhibition abnormalities in pediatric obsessive compulsive disorder. Arch Gen Psychiat 1997;54:831–8.CrossRefGoogle ScholarPubMed
Rubia, KOosterlaan, JSergeant, JBrandeis, DV Lecuwen, THInhibitory dysfunction in hyperactive boys. Behav Brain Res 1998;94: 25–32.CrossRefGoogle ScholarPubMed
Rubia, KOvermeyer, STaylor, EBrammer, MWilliams, SRSimmomns, Aet al. Frontalisation with age: mapping neurodevelopmental trajectories with fMRI. Neurosci Biobehav R 2000;24:13–9.CrossRefGoogle ScholarPubMed
Rubia, KRussell, TOvermeyer, SBrammer, MJBullmore, ETSharma, Tet al. Mapping motor inhibition: conjunctive brain activations across different versions of go/no-go tasks. NeuroImage 2001;13:250–61.CrossRefGoogle Scholar
Rubia, KSmith, ABrammer, MTaylor, ERight inferior prefrontal cortex mediates response inhibition while mesial prefrontal cortex is responsible for error detection. NeuroImage 2003;20:351–8.CrossRefGoogle ScholarPubMed
Rubia, KSmith, ATaylor, E The Maudsley Attention and Response Suppression Task (MARS) battery: a test battery to measure impulsiveness applied to children with Attention Deficit Hyperactivity Disorder (ADHD). Child Neuropsychol, in press.Google Scholar
Rubia, KTaylor, EOksannen, SOvermeyer, SBullmore, ENewman, SNeuropsychological analyses of impulsiveness in chilhood hyperactivity. Br J Psychiatry 2001;179:138–43.CrossRefGoogle Scholar
Savage, CRBaer, LKeuthen, NJBrown, HDRauch, SLJenike, MAOrganizational strategies mediata non-verbal memory impairment in obsessive-compulsive disorder. Biol Psychiatry 1999;45:905–16.CrossRefGoogle Scholar
Saxena, SRauch, SLFunctional neuroimaging and the neuroanatomy of obsessive-compulsive disorder. Psychiat Clin North Am 2000;23:563–86.CrossRefGoogle ScholarPubMed
Schmidtke, KSchorb, AWinkelmann, GHohagen cognitive frontal lobe dysfunction in obsessive-compulsive disorder. Biol Psychiatry 1998;43:666–73.CrossRefGoogle ScholarPubMed
Seisdedos, NCorral, SCordero, ADe La Cruz, MVPereña, JEsca la de Inteligencia Wechsler para adultos - XIII. Madrid. TEA Ediciones 1999.Google Scholar
Serra, FPPalma, VNolfe, GBuscaino, GAAn electrophysiological study in obsessional compulsive disorders. Acta Neurol 1994; 16:240–8.Google ScholarPubMed
Stein, DJHollander, ESimeon, DCohen, LIslam, MNAronowitz, BNeurological soft signs in female trichotillomania patients, obsessive compulsive disorder patients, and healthy control subjects. J Neuropsych Clin N 1994;6:184–7.Google ScholarPubMed
Stein, DJLudik, JA neural network of obsessive-compulsive disorder: cognitive disinhibition and neurotransmitter dysfunction modelling. Med Hypotheses 2000;55:168–76.CrossRefGoogle ScholarPubMed
Stein, DJObsessive-compulsive disorder. Lancet 2002;360:397–405.CrossRefGoogle ScholarPubMed
Tallis, FPratt, PJamani, NObsessive compulsive disorder, checking, and non-verbal memory: a neuropsychological investigation. Behav Res Ther 1998;37:161–6.CrossRefGoogle Scholar
Tallis, EThe neuropsychology of obsessive-compulsive disorder: 29review and consideration of clinical implications. Brit J Clin Psychol 1997;36:3–20.CrossRefGoogle ScholarPubMed
Terrence, ENHaller, EJVisual attention in obsessive-compulsive disorder. Psychiatry Res 1993;49:183–96.Google Scholar
Tot, SOzge, ACopmelekoglu, UYazici, KBal, NAssociation of QEEG findings with clinical characteristics of OCD: evidence of left frontotemporal dysfunction. Can J Psychiat 2002;47:538–45.CrossRefGoogle ScholarPubMed
Van Boxtel, GJVan der Molen, MWJennings, JRBrunia, CHA psychophysiological analysis of inhibitory motor control in the stopsignal paradigm. Biol Psychol 2001;58:229–62.CrossRefGoogle Scholar
Van der Wee, VMRamsey, NFJansma, JMDenys, DAvan Megen, HGWestenberg, HGet al. Spatial working memory deficits in obsessive compulsive disorder are associated with excessive engagement of the medial frontal cortex. NeuroImage 2003;20:2271–80.CrossRefGoogle ScholarPubMed
Veale, DMSahakian, BJOwen, AMMarks, ISpecific cognitive deficits in tests sensitive to frontal lobe dysffinction in obsessivecompulsive disorder. Psychol Med 1996;26:1261 –9.CrossRefGoogle Scholar