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¿Es esencial la literatura gris para un mejor control del sesgo de publicación en psiquiatría? Un ejemplo de tres meta-análisis de la esquizofrenia

Published online by Cambridge University Press:  12 May 2020

José Luis R Martín
Affiliation:
Departamento de Investigación Clínica, Fundación para la Investigación de la Salud en Castilla-La Mancha (FISCAM), Edificio Bulevar, C/Berna, n°2. Local 0-2, 45003-Toledo, Castilla-La Mancha, Espana
Víctor Pérez
Affiliation:
Departamento de Psiquiatría, Hospital de la Santa Creu i Sant Pau, Barcelona, Espan̄a
Montse Sacristán
Affiliation:
Departamento de Investigación Clínica, Fundación para la Investigación de la Salud en Castilla-La Mancha (FISCAM), Edificio Bulevar, C/Berna, n°2. Local 0-2, 45003-Toledo, Castilla-La Mancha, Espana
Enric Álvarez
Affiliation:
Departamento de Psiquiatría, Hospital de la Santa Creu i Sant Pau, Barcelona, Espan̄a
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Resumen

Las revisiones sistemáticas en salud mental se han convertido en herramientas útiles para los profesionales sanitarios en vista de la enorme cantidad y la naturaleza heterogénea de la información biomédica disponible hoy. Por tanto, para determinar el riesgo de sesgo en los estudios evaluados y para evitar el sesgo al generalizar las conclusiones de las revisiones, es importante utilizar métodos muy estrictos en las revisiones sistemáticas. Un sesgo que puede afectar a la generalización de los resultados es el sesgo de publicación, que está determinado por la naturaleza y dirección de los resultados del estudio. Para controlar o minimizar este tipo de sesgo, los autores de revisiones sistemáticas realizan búsquedas exhaustivas de las bases de datos médicas y amplían los hallazgos emprendiendo a menudo búsquedas de literatura gris (material que no está publicado formalmente). Este artículo intenta mostrar las consecuencias (y el riesgo) de generalizar las implicaciones de la literatura gris en el control del sesgo de publicación, como se propuso en un trabajo sistemático reciente. Repitiendo los análisis para el mismo desenlace de tres revisiones sistemáticas diferentes que incluían tanto literatura gris como trabajos publicados, nuestros resultados mostraron que la confusión entre literatura gris y sesgo de publicación puede afectar a los resultados de un meta-análisis concreto.

Type
Comunicación breve
Copyright
Copyright © European Psychiatric Association 2006

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¿Es esencial la literatura gris para un mejor control del sesgo de publicación en psiquiatría? Un ejemplo de tres meta-análisis de la esquizofrenia
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