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Propofol inhibits potassium chloride induced contractions of isolated human umbilical vessels

Published online by Cambridge University Press:  27 January 2006

E. Caliskan ,
Z. Kayhan  and
H. Tufan
E. Caliskan
Affiliation:
Baskent University, Faculty of Medicine, Adana Teaching and Medical Research Center, Department of Anaesthesiology, Adana, Turkey
Z. Kayhan
Affiliation:
Baskent University, Faculty of Medicine, Department of Anaesthesiology, Ankara, Turkey
H. Tufan
Affiliation:
Baskent University, Faculty of Medicine, Department of Pharmacology, Ankara, Turkey
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Abstract

Summary

Background and objective: We have evaluated the effects of propofol and its relationship with K+ channels on human isolated umbilical vessels. Methods: Umbilical vessel rings were suspended in isolated organ baths containing Krebs–Ringer solution. In the first series of experiments the effect of propofol (10−9–10−4M) was examined in a concentration-dependent manner on umbilical vessels precontracted with KCl (60 mmol). In the second series, these effects were studied in the presence of tetraethylammonium. Results: A mild contraction was produced by low dose propofol in both precontracted umbilical artery and umbilical vein segments. 10−4M propofol caused significant relaxation in both umbilical artery and umbilical vein. The relaxation response was significantly reduced by the addition of 10−1 M tetraethylammonium. Conclusion: These results suggested that the responses of propofol on KCl-induced contractions of both umbilical artery and vein were dose dependent, and this effect involved Ca2+ activated K+ channels.

Keywords

INTRAVENOUS ANAESTHETIC AGENTS, propofolUMBILICAL ARTERIESUMBILICAL VEINSPOTASSIUM CHANNELSVASOCONSTRICTION
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 23 , Issue 5 , May 2006 , pp. 411 - 417
Copyright
2006 European Society of Anaesthesiology

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