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Pharmacological study of BRS, a new bicarbonated Ringer's solution, in partially hepatectomized rabbits

Published online by Cambridge University Press:  28 July 2005

K. Satoh ,
M. Ohtawa ,
E. Okamura ,
T. Satoh  and
A. Matsuura
K. Satoh
Affiliation:
Pharmacology Laboratory, Shimizu Research Center, Shimizu Pharmaceutical Co., Ltd., Shizuoka, Japan
M. Ohtawa
Affiliation:
Pharmacology Laboratory, Shimizu Research Center, Shimizu Pharmaceutical Co., Ltd., Shizuoka, Japan
E. Okamura
Affiliation:
Pharmacology Laboratory, Shimizu Research Center, Shimizu Pharmaceutical Co., Ltd., Shizuoka, Japan
T. Satoh
Affiliation:
Tokyo Clinical Development Center Tokyo, Japan
A. Matsuura
Affiliation:
Pharmacology Laboratory, Shimizu Research Center, Shimizu Pharmaceutical Co., Ltd., Shizuoka, Japan
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Summary

Background and objective: The effects of bicarbonated Ringer's solution were evaluated and compared with those of acetated Ringer's, lactated Ringer's and Ringer's solutions in partially hepatectomized rabbits. Method: Animals were randomly divided into six groups (n = 6 in each group): a sham-operated group, an operated group without infusion, and four operated groups with infusions of each of the four Ringer's solutions. Each Ringer's solution was intravenously administered at 40 mL kg−1 h−1 for 1.5 h. Arterial blood gases, plasma magnesium concentrations and cardiovascular parameters were analysed. Results: The partial hepatectomy-induced decrement of base excess was inhibited by bicarbonated Ringer's solution more remarkably than by either lactated or plain solutions (P < 0.01). The alkalinizing effect of bicarbonated Ringer's solution tended to be more marked than that of the acetated solution but not significantly so. Plasma magnesium concentrations were well maintained by bicarbonated solution as compared to the other solutions (P < 0.01). Conclusions: These results suggest that bicarbonated Ringer's solution is the most suitable perioperative solution for metabolic acidosis and plasma electrolyte balance among the Ringer's solutions tested.

Keywords

RINGER'S SOLUTION, bicarbonate, acetate, lactateACIDOSIS, metabolicRABBITHEPATECTOMY, partial
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 22 , Issue 8 , August 2005 , pp. 624 - 629
Copyright
© 2005 European Society of Anaesthesiology

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References

Schumer W, Moss GS, Nyhus LM. Metabolism of lactic acid in the macacus rhesus monkey in profound shock. Am J Surg 1969; 118: 200–205.Google Scholar
Nakatani T. Overview of the effects of Ringer's acetate solution and a new concept: renal ketogenesis during hepatic inflow occlusion. Method Find Exp Clin Pharmacol 2001; 23: 519–528.Google Scholar
Ballard FJ. Supply and utilization of acetate in mammals. Am J Clin Nutr 1972; 25: 773–779.Google Scholar
Cialanfi E, Fonnesu A. Time-course of injected acetate in normal and depancreatized dogs. Biochem J 1954; 57: 171–175.Google Scholar
Oi Y, Ogawa R. Regulation of serum electrolytes changes during surgical operation and anesthesia. J Clin Anesth (Jpn) 1994; 14: 26–29.Google Scholar
Aglio LS, Stanford GG, Maddi R, Boyd III JL, Nussbaum S, Chernow B. Hypomagnesemia is common following cardiac surgery. J Cardiothor Vasc Anesth 1991; 5: 201–208.Google Scholar
Chernow B, Bamberger S, Stoiko M et al. Hypomagnesemia in patients in postoperative intensive care. Chest 1989; 95: 391–397.Google Scholar
Ryzen E, Wagers PW, Singer FR, Rude RK. Magnesium deficiency in a medical ICU population. Crit Care Med 1985; 13: 19–21.Google Scholar
Altura BM, Altura BT, Carella A. Magnesium deficiency-induced spasms of umbilical vessels: relation to preeclampsia, hypertension, growth retardation. Science 1983; 221: 376–377.Google Scholar
Aizawa Y, Ohmori T, Imai K, Nara Y, Matsuoka M, Hirasawa Y. Depressant action of acetate upon the human cardiovascular system. Clin Nephrol 1977; 8: 477–480.Google Scholar
Liang CS, Lowenstein JM. Metabolic control of the circulation. Effects of acetate and pyruvate. J Clin Invest 1978; 62: 1029–1038.Google Scholar
Kirkendol RL, Pearson JE, Bower JD, Holbert RD. Myocardial depressant effects of sodium acetate. Cardiovasc Res 1978; 12: 127–136.Google Scholar
Olinger GN, Werner PH, Bonchek LI, Boerboom LE. Vasodilator effects of the sodium acetate in pooled protein function. Ann Surg 1979; 190: 305–311.Google Scholar
Kirkendol PL, Devia CJ, Bower JD, Holbert RD. A comparison of the cardiovascular effects of sodium acetate, sodium bicarbonate and other potential sources of fixed base in hemodialysate solutions. Trans Am Soc Artif Intern Organs 1977; 23: 399–400.Google Scholar
Sandee MH, John CT. Effects of sodium acetate, bicarbonate and lactate on acid–base status in anaesthetized dogs. J Vet Pharmacol Therap 1981; 4: 51–61.Google Scholar
Watten RH, Gutman RA, Fresh JW. Comparison of acetate, lactate and bicarbonate in treating the acidosis of cholera. Lancet 1969; 2: 512–514.Google Scholar
Altura BM, Altura BT. Magnesium ions and concentration of vascular smooth muscles: relationship to some vascular disease. Fed Proc 1981; 40: 2627–2629.Google Scholar
Altura BM, Altura BT. Influence of magnesium on vascular smooth muscle and serum biochemical parameters from diabetic and hypertensive rat. Magnesium 1983; 2: 253–266.Google Scholar
Altura BM, Altura BT. Mg deficiency-induced spasm of umbilical vessels: relationship to preeclampsia, hypertension, growth retardation. Science 1983; 221: 376–377.Google Scholar
Altura BM, Altura BT. Interaction of Mg and K on blood vessels – aspects in view of hypertension. Magnesium 1984; 3: 175–194.Google Scholar
Altura BM, Altura BT. Interaction of Mg and K on blood vessels – aspects in view of stroke. Magnesium 1984; 3: 195–211.Google Scholar
Altura BM, Altura BT. Mg, electrolyte transport and coronary vascular tone. Drugs 1984; 28: 120–142.Google Scholar
Rude RK, Monoogian C, Ehrlich L, Ehrlich P, DeRusso E, Ryzen E, Nadler J. Mechanisms of blood pressure regulation by Mg in man. Magnesium 1989; 8: 266–273.Google Scholar
Turlapaty PD, Altura BM. Mg deficiency produces spasms of coronary arteries: relationship to etiology of sudden death ischemic heart disease. Science 1980; 208: 198–200.Google Scholar
Kara H, Sahin N, Ulusan V. Magnesium infusion reduces perioperative pain. Eur J Anaesthesiol 2002; 19: 52–56.Google Scholar
Wilkes NJ, Mallett SV, Peachey T. Correction of ionized plasma magnesium during cardiopulmonary bypass reduces the risk of postoperative cardiac arrhythmia. Anesth Analg 2002; 95: 828–834.Google Scholar
Dittrich S, Germanakis J, Dahnert I. Randomised trial on the influence of continuous magnesium infusion on arrhythmias following cardiopulmonary bypass surgery for congenital heart disease. Intens Care Med 2003; 29: 1141–1144.Google Scholar
Forlani S, Moscarelli M, Scafuri A. Combination therapy for prevention of atrial fibrillation after coronary artery bypass surgery: a randomized trial of sotalol magnesium. Card Electrophysiol Rev 2003; 7: 168–171.Google Scholar