Skip to main content Accessibility help
×
Home

Mitochondrial myopathies and anaesthesia

  • E. A. Shipton (a1) and D. O. Prosser (a1)

Abstract

Summary

The mitochondrial myopathies consist of a heterogeneous group of disorders caused by structural and functional abnormalities in mitochondria leading to involvement of the nervous system and muscles as well as other organ systems. The peculiar genetic characteristics of mitochondrial DNA impart distinctive properties to these disorders. The pathophysiology is presented. The methods employed in making the correct diagnosis, the preoperative patient assessment and correction of metabolic dysfunctions and anaesthetic techniques used, are highlighted. The conditions are briefly reviewed and suggestions are made for the safe anaesthetic management of affected patients.

Copyright

Corresponding author

Correspondence to: Edward Shipton, Department of Anaesthesia, Christchurch School of Medicine and Health Sciences, University of Otago, 60 Hawthornden Road, Avonhead, Private Bag 4345, 8001 Christchurch, New Zealand. E-mail: shiptonea@xtra.co.nz; Tel: +64 (3) 357 8599; Fax: +64 (3) 357 2594

References

Hide All

References

Morgan P, Hoppel CL, Sedensky MM. Mitochondrial defects and anesthetic sensitivity. Anesthesiology 2002; 96: 12681270.
Plasterer TN, Smith TF, Mohr SC. Survey of human mitochondrial diseases using new genomic/proteomic tools. Gene Biol 2001; 2: 116.
Solano A, Playan A, Loez-Perez MJ, Montoya J. Genetic diseases of the mitochondrial DNA in humans. Salud Publica Mexico 2001; 43: 151161.
Rosaeg OP, Morrison S, MacLeod JP. Anaesthetic management of labour and delivery in the parturient with mitochondrial myopathy. Can J Anaesth 1996; 43: 403407.
Mehndiratta MM, Agarwal P, Tatke M, Krishnamurthy M. Neurological mitochondrial cytopathies. Neurol India 2002; 50: 162167.
Wisely NA, Cook PR. General anaesthesia in a man with mitochondrial myopathy undergoing eye surgery. Eur J Anaesthesiol 2001; 18: 333335.
Hsiao PN, Cheng TJ, Tseng HC, Chuang YH, Kao PF, Tsai SK. Spinal anesthesia in MELAS syndrome: a case with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes. Acta Anaesthesiol Sin 2000; 38: 107110.
Wredenberg A, Wibom R, Wilhelmsson H, et al. Increased mitochondrial mass in mitochondrial myopathy mice. Proc Natl Acad Sci USA 2002; 99: 1506615071.
Schapira AH. Mitochondrial disorders. Biochem Biophys Acta 1999; 1410: 99102.
Wallace JJ, Perndt H, Skinner M. Anaesthesia and mitochondrial disease. Paediatr Anaesth 1998; 8: 249254.
Ciccotelli KK, Prak EL, Muravchick S. An adult with inherited mitochondrial encephalopathy: report of a case. Anesthesiology 1997; 87: 12401242.
Cheam EWS, Critchley LAH. Anesthesia for a child with complex I respiratory chain enzyme deficiency. J Clin Anesth 1998; 10: 524527.
Dalta V, Jain P, Mehndirrata MM, et al. Myoclonic epilepsy with red ragged fibres. Indian Pediatr 1999; 36: 817819.
Nouette-Gaulain K, Forestier F, Malgat M, Marthan R, Mazat JP, Sztark F. Effects of bupivacaine on mitochondrial energy metabolism in heart of rats following exposure to chronic hypoxia. Anesthesiology 2002; 97: 15071511.
Farag E, Argalious M, Narouze S, DeBoer G, Tome J. The anesthetic management of ventricular septal defect (VSD) repair in a child with mitochondrial cytopathy. Can J Anaesth 2002; 49: 958962.
Thompson VA, Wahr JA. Anesthetic considerations in patients presenting with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome. Anesth Analg 1997; 85: 14041406.
Sharma AD, Erb E, Schulman SR, Sreeram G, Slaughter TF. Anaesthetic considerations for a child with combined Prader–Willi syndrome and mitochondrial myopathy. Paediatr Anaesth 2001; 11: 488490.
Taivassalo T, Abbott A, Wyrick P, Haller RG. Venous oxygen levels during aerobic forearm exercise: and index of impaired oxidative metabolism in mitochondrial myopathy. Ann Neurol 2002; 51: 3844.
Ohtani Y, Miike T, Ishitsu T, et al. A case of malignant hyperthermia with mitochondrial dysfunction. Brain Dev 1985; 7: 249.
Steensberg A, Vissing J, Pedersen BK. Lack of IL-6 production during exercise in patients with mitochondrial myopathy. Eur J Appl Physiol 2001; 84: 155157.
Vladutiu GD, Bennett MJ, Smail D, Wong LJ, Taggart RT, Lindsley HB. A variable myopathy associated with heterozygosity for the R503C mutation in the carnitine palmitoyltransferase II gene. Mol Genet Metab 2000; 70: 134141.

Keywords

Mitochondrial myopathies and anaesthesia

  • E. A. Shipton (a1) and D. O. Prosser (a1)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed