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Effect of three different doses of urapidil on blood glucose concentrations in the streptozotocin diabetic rat

  • K. P. Ittner (a1) (a2), M. Bucher (a1), M. Zimmermann (a1), H. F. Grobecker (a2), B. K. Krämer (a3) and K. Taeger (a1)...

Abstract

Background and objective: Diabetes mellitus associated with hypertension often causes perioperative complications. The α1-adrenoceptor antagonist/5-hydroxytryptamine-1A receptor agonist urapidil is an approved drug used in hypertension and hypertensive emergencies. 5-Hydroxytryptamine-1A (5-HT1A) receptor agonists impair glucose metabolism. To evaluate a possible dose-dependent hyperglycaemic effect of urapidil due to its 5-HT1A receptor agonistic properties, the effect of three doses of urapidil on hyperglycaemia in the streptozotocin diabetic rat was investigated.

Methods: Male Wistar-Kyoto rats were made diabetic by streptozotocin and randomly allocated to the following daily treatments for 7 days (n = 6 each): urapidil 6 mg kg−1, urapidil 20 mg kg−1, urapidil 60 mg kg−1, insulin 4 IU kg−1 subcutaneously. One diabetic group and one non-diabetic healthy group served as controls.

Results: Treatment for 7 days with urapidil 20 mg kg−1 and urapidil 60 mg kg−01 reduced mean glucose concentrations significantly (urapidil-20: 15.6 ± 1.1 mmol L−1P = 0.023; urapidil-60: 15.8 ± 0.8 mmol L−1, P = 0.04) compared with diabetic controls (20.9 ± 0.8 mmol L−1), whereas those after urapidil 6 mg kg−1 were similar to diabetic controls. Insulin treatment normalized blood glucose concentrations.

Conclusions: The α1-adrenoceptor antagonist/5-HT1A receptor agonist urapidil has no hyperglycaemic effect on experimental diabetes mellitus, even in high doses, despite its 5-HT1A receptor agonistic properties.

Copyright

Corresponding author

Correspondence to: Karl Ittner, Department of Anaesthesiology, University of Regensburg, Franz Josef Strauss Allee 11, D-93042 Regensburg, Germany. E-mail: karl-peter.ittner@klinik.uni-regensburg.de; Tel: +49 941 944 7801; Fax: +49 941 944 7802

Keywords

Effect of three different doses of urapidil on blood glucose concentrations in the streptozotocin diabetic rat

  • K. P. Ittner (a1) (a2), M. Bucher (a1), M. Zimmermann (a1), H. F. Grobecker (a2), B. K. Krämer (a3) and K. Taeger (a1)...

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