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The effect of intrathecal medetomidine on small bowel transit in the rat

  • L. Bilir (a1), B. Yelken (a2), S. Guleç (a2), A. Bilir (a2) and S. Ekemen (a2)...

Abstract

Summary

Background and objective: Gastrointestinal motility is influenced by abdominal trauma, laparotomy and particularly by intestinal ischaemia. The reflex inhibition of gastrointestinal motility is mediated mainly by the sympathetic nervous system. There are reports on the effects of systemically applied α2-adrenoceptor agonists on gastric emptying and recovery of bowel motility, but the effect of spinally applied α2-adrenoceptor agonists on intestinal motility has not been studied. The aim of this study was to investigate the effects of intrathecal medetomidine on gastrointestinal transit in rats after transient intestinal ischaemia.

Methods: Forty rats were randomly assigned to four groups of 10 each. Intrathecal catheter insertion and laparotomy were performed on each rat. Saline (10 μL) was injected intrathecally in Groups A and B. Medetomidine (10 μg in 10 μL) was injected intrathecally in Groups C and D. Intestinal ischaemia was induced in Groups B and D. Gastrointestinal transit was determined by measuring the length that a standardized marker meal of activated charcoal had travelled. Intrathecal medetomidine was compared to intrathecal saline in their effect on intestinal motility after 30 min period of bowel ischaemia.

Results: Laparotomy and intestinal ischaemia slowed gastrointestinal transit. Intrathecal medetomidine accelerated transit in both ischaemia and non-ischaemia groups.

Conclusion: Intrathecal medetomidine markedly accelerated small intestinal transit and may also hasten the recovery from post-ischaemic paralytic ileus.

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Corresponding author

Correspondence to: Ayten Bilir, Department of Anaesthesiology and Reanimation, Osmangazi University Medical Faculty, 26100, Eskisehir, Turkey. E-mail: aytbilir@yahoo.com; Tel: +90 222 239 90 52; Fax: +90 222 220 59 30

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References

Udassin R, Eimerl D, Schiffman J, Haskel Y. Epidural anesthesia accelerates the recovery of postischemic bowel motility in rat. Anesthesiology 1994; 80: 832836.
Guisan YJ, Hreno A, Gurd FN. Effect of acute ischaemia on the motility of the bowel in the awake dog. Eur Surg Res 1975; 7: 2233.
Bardon T, Ruckebusch Y. Comparative effects of opiate agonists on proximal and distal colonic motility in dogs. Eur J Pharmacol 1985; 110: 329334.
Cheadle W, Vitale G, Mackie C, Cuschieri A. Prophylactic postoperative nasogastric decompression. A prospective study of its requirement and the influence of cimetidine in 200 patients. Ann Surg 1985; 202: 361366.
Pironi L, Stanghellini V, Miglioli M, et al. Fat-induced ileal brake in humans: a dose-dependent phenomenon correlated to the plasma levels of peptide YY. Gastroenterology 1993; 105: 733739.
Yee MK, Evans WD, Facey PE, Hayward MW, Rosen M. Gastric emptying and small bowel transit in male volunteers after IM ketorolac and morphine. Br J Anaesth 1991; 67: 426431.
Ahn H, Bronge A, Johansson K, Ygge H, Lindhagen J. Effect of continuous postoperative epidural analgesia on intestinal motility. Br J Surg 1988; 75: 11761178.
Wattwil M, Thoren T, Hennerdal S, Garvill JE. Epidural analgesia with bupivacaine reduces postoperative paralytic ileus after hysterectomy. Anesth Analg 1989; 68: 353358.
Carli F, Trudel JL, Belliveau P. The effect of intraoperative thoracic epidural anesthesia and postoperative analgesia on bowel function after colorectal surgery: a prospective, randomized trial. Dis Colon Rectum 2001; 44: 10831089.
Doze VA, Chen BX, Maze M. Dexmedetomidine produces a hypnotic–anesthetic action in rats via activation of central alpha-2 adrenoceptors. Anesthesiology 1989; 71: 7579.
Segal IS, Vickery RG, Walton JK, Doze VA, Maze M. Dexmedetomidine diminishes halothane anesthetic requirements in rats through a postsynaptic alpha-2 adrenergic receptor. Anesthesiology 1988; 69: 818823.
Tanila H, Kauppila T, Taira T. Inhibition of intestinal motility and reversal of post laparotomy ileus by selective alpha-2 adrenergic drugs in the rats. Gastroenterology 1993; 104: 819824.
Asai T, Mapleson WW, Power I. Differential effects of clonidine and dexmedetomidine on gastric emptying and gastrointestinal transit in the rat. Br J Anaesth 1997; 78: 301307.
Ruwart MJ, Klepper MS, Rush BD. Clonidine delays small intestinal transit in the rat. J Pharm Exper Therap 1980; 212: 487490.
Gordh TJ, Jansson I, Hartvig P, Gillberg PG, Post C. Interactions between noradrenergic and cholinergic mechanism involved in spinal nociceptive processing. Acta Anesthesiol Scand 1989; 33: 3947.
Livingston EH, Passaro EP Jr. Postoperative ileus. Dig Dis Sci 1990; 35: 121132.
Liu SS, Carpenter RL, Mackey DC, et al. Effects of perioperative analgesic technique on rate of recovery after colon surgery. Anesthesiology 1995; 83: 757765.
Asai T, Mapleson WW, Power I. Interactive effect of morphine and dexmedetomidine on gastric emptying and gastrointestinal transit in the rat. Br J Anaesth 1998; 80: 6367.
Detweiler DJ, Eisenach JC, Tong C, Jackson C. A cholinergic interaction in alpha-2 adrenoceptor-mediated antinociception in sheep. J Pharmacol Exp Ther 1993; 265: 536542.
Stamford JA. Descending control of pain. Br J Anaesth 1995; 75: 217227.
Klimscha W, Tong C, Eisenach JC. Intrathecal alpha-2 adrenergic agonists stimulate acetylcholine and norepinephrine release from the spinal cord dorsal horn in sheep. Anesthesiology 1997; 87: 110116.
Hood D, Mallak K, Eisenach J, Tong C. Interaction between intrathecal neostigmine and epidural clonidine in human volunteers. Anesthesiology 1996; 85: 315325.
Fargeas MJ, Fioramonti J, Bueno L. Central alpha-2 adrenergic control of the pattern of small intestinal motility in rats. Gastroenterology 1986; 91: 14701475.
Pertovaara A. Antinociception in bulboreticular neurons of the rat produced by spinally administered medetomidine, an alpha-2 adrenoceptor agonist. Eur J Pharmacol 1991; 204: 914.
Meert TF, De Kock M. Potentiation of the analgesic properties of fentanyl-like opioids with alpha-2 adrenoceptor agonists in rats. Anesthesiology 1994; 81: 677688.
Reilly JA, Quigley EMM, Forst CF, Rikkers LF. Small intestinal transit in the portal hypertensive rat. Gastroenterology 1991; 100: 670674.

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The effect of intrathecal medetomidine on small bowel transit in the rat

  • L. Bilir (a1), B. Yelken (a2), S. Guleç (a2), A. Bilir (a2) and S. Ekemen (a2)...

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