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Effect of balanced analgesia with buprenorphine on pain response and general anaesthesia requirement during lithotripsy procedures

  • P. Tauzin-Fin (a1), S. Delort-Laval (a1), M.-C. Krol-Houdek (a1), P. Maurette (a1) and B. Bannwarth (a2)...

Abstract

The effectiveness of a balanced analgesia with buprenorphine ketoprofen-propacetamol for pain control during extracorporeal shock wave lithotripsy (ESWL) was evaluated in order to reduce the requirements for general anaesthesia. Two hundred and ninety-one consecutive patients were included in a randomized, placebo-controlled, double-blind study. Patients in each group received midazolam 5 mg pre-operatively as premedication. The subjects then received either placebo (group 1), buprenorphine 0.3 mg (group 2) or the combination buprenorphine 0.3 mg plus ketoprofen 100 mg and propacetamol 2 g (group 3) intravenously (i.v.) at a constant rate. The treatment was started 45 min prior to ESWL. Pain was assessed using a three-point verbal scale: (0)no pain; (1) moderate pain; and (2) intense pain needing general anaesthesia. The patients assessed their pain intensity on a 0–100 mm visual analogue scale. Only 69% of group 1 patients received ESWL with midazolam premedication. Buprenorphine provided good analgesia in 87% of group 2 patients, while the combination buprenorphine-ketoprofen-propacetamol was effective in 99% of group 3 patients (P<0.05). The incidence of nausea and vomiting was similar in the buprenorphine groups. No respiratory depression was reported. In conclusion, the buprenorphine-ketoprofen-propacetamol combination provided effective analgesia, allowing ESWL to be performed without the need for general anaesthesia.

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Corresponding author

Correspondence: P. Tauzin-Fin.

Keywords

Effect of balanced analgesia with buprenorphine on pain response and general anaesthesia requirement during lithotripsy procedures

  • P. Tauzin-Fin (a1), S. Delort-Laval (a1), M.-C. Krol-Houdek (a1), P. Maurette (a1) and B. Bannwarth (a2)...

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