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Desflurane increases heart rate independent of sympathetic activity in dogs

  • O. Picker (a1), L. A. Schwarte (a1), A. W. Schindler (a1) and T. W. L. Scheeren (a1)

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Summary

Background and objective: Desflurane has been shown to increase sympathetic activity and heart rate (HR) in a concentration-dependent manner. Nevertheless, desflurane, like all other volatile anaesthetics, increased HR in parallel to vagal inhibition in a previous study. Therefore, our hypothesis is that desflurane elicits tachycardia by vagal inhibition rather than by activation of the sympathetic nervous system.

Methods: Six dogs were studied awake and during desflurane anaesthesia (1 and 2 MAC) alone, after pre-treatment with propranolol (2 mg kg−1 followed by 1 mg kg−1 h−1), or after pre-treatment with atropine (0.1 mg kg−1 followed by 0.05 mg kg−1 h−1). The effects on HR and HR variability were compared by an analysis of variance (P < 0.05). HR variability was analysed in the frequency domain as power in the high-(0.15–0.5 Hz, vagal activity) and low-frequency range (0.04–0.15 Hz, sympathetic and vagal activity).

Results: HR increased during 2 MAC of desflurane from about 60 (awake) to 118 ± 2 beats min−1 (mean ± SEM) in controls and to 106 ± 3 beats min−1 in dogs pre-treated with propranolol. In contrast, pre-treatment with atropine increased HR from 64 ± 2 to 147 ± 5 beats min−1 (awake) and HR decreased to 120 ± 5 beats min−1 after adding desflurane. High-frequency power correlated inversely with HR (r2 = 0.95/0.93) during desflurane alone and in the presence of β-adrenoceptor blockade, with no significant difference between regression lines. There was no correlation between these variables during atropine/desflurane.

Conclusions: The increase in HR elicited by desflurane mainly results from vagal inhibition and not from sympathetic activation.

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Corresponding author

Correspondence to: Olaf Picker, Department of Anaesthesiology, Heinrich-Heine-University, Moorenstrasse 5, D–40225 Düsseldorf, Germany. E-mail: olaf.picker@uni-duesseldorf.de; Tel: +49 211 811 3990; Fax: +49 211 811 3954

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References

Scher AM, Young AC. Reflex control of heart rate in the unanesthetized dog. Am J Physiol 1970; 218: 780789.
Picker O, Scheeren TWL, Arndt JO. Inhalation anaesthetics increase heart rate by decreasing cardiac vagal activity. Br J Anaesth 2001; 87: 748754.
Ebert TJ, Muzi M. Sympathetic hyperactivity during desflurane anesthesia in healthy volunteers. A comparison with isoflurane. Anesthesiology 1993; 79: 444453.
Ebert TJ, Muzi M, Lopatka CW. Neurocirculatory responses to sevoflurane in humans. A comparison to desflurane. Anesthesiology 1995; 83: 8895.
Ebert TJ, Perez F, Uhrich TD, Deshur MA. Desflurane-mediated sympathetic activation occurs in humans despite preventing hypotension and baroreceptor unloading. Anesthesiology 1998; 88: 12271232.
Pac-Soo CK, Ma D, Wang C, Chakrabarti MK, Whitwam JG. Specific actions of halothane, isoflurane, and desflurane on sympathetic activity and A delta and C somatosympathetic reflexes recorded in renal nerves in dogs. Anesthesiology 1999; 91: 470478.
Gueugniaud PY, Hanouz JL, Vivien B, Lecarpentier Y, Coriat P, Riou B. Effects of desflurane in rat myocardium: comparison with isoflurane and halothane. Anesthesiology 1997; 87: 599609.
Kersten J, Pagel PS, Tessmer JP, Roerig DL, Schmeling WT, Warltier DC. Dexmedetomidine alters the hemodynamic effects of desflurane and isoflurane in chronically instrumented dogs. Anesthesiology 1993; 79: 10221032.
Boban M, Stowe DF, Buljubasic N, Kampine JP, Bosnjak ZJ. Direct comparative effects of isoflurane and desflurane in isolated guinea pig hearts. Anesthesiology 1992; 76: 775780.
van Leersum E. Eine Methode zur Erleichterung der Blutdruckmessung bei Tieren. Pflügers Arch 1911; 142: 377395.
Picker O, Schindler A, Scheeren TWL. Accuracy and reproducibility of long-term implanted transit-time ultrasound flow probes in dogs. Intensive Care Med 2000; 26: 601607.
Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation, and clinical use. Circulation 1996; 93: 10431065.
Ohsumi H, Sakamoto M, Yamazaki T, Okumura F. Effects of fentanyl on carotid sinus baroreflex control of circulation in rabbits. Am J Physiol 1989; 256: R625R631.
Hammel HT, Wyndham CA, Hardy JD. Heat production and heat loss in the dog at 8–36°C environmental temperature. Am J Physiol 1958; 194: 99108.
Doorley BM, Waters SJ, Terrell RC, Robinson JL. MAC of I-653 in beagle dogs and New Zealand white rabbits. Anesthesiology 1988; 69: 8991.
Smith I, White PF, Nathanson M, Gouldson R. Propofol. An update on its clinical use. Anesthesiology 1994; 81: 10051043.
AHFS Drug Information. Cardiovascular Drugs. Bethesda: American Society of Health-System Pharmacists, 1996: 12021209.
Takamura M, Parent R, Cernacek P, Lavallee M. Influence of dual ET(A)/ET(B)-receptor blockade on coronary responses to treadmill exercise in dogs. J Appl Physiol 2000; 89: 20412048.
Stein PK, Kleiger RE. Insights from the study of heart rate variability. Annu Rev Med 1999; 50: 249261.
Berntson GG, Bigger Jr JT, Eckberg DL, et al. Heart rate variability: origins, methods, and interpretive caveats. Psychophysiol 1997; 34: 623648.
Hirsch JA, Bishop B. Respiratory sinus arrhythmia in humans: how breathing pattern modulates heart rate. Am J Physiol 1981; 241: H620H629.
Brown TE, Beightol LA, Koh J, Eckberg DL. Important influence of respiration on human R–R interval power spectra is largely ignored. J Appl Physiol 1993; 75: 23102317.
Weiskopf RB, Eger EI, Daniel M. Fentanyl, esmolol, and clonidine blunt the transient cardiovascular stimulation induced by desflurane in humans. Anesthesiology 1994; 81: 13501355.
Vogt A, Thämer V. Vagal and sympathetic reflexes of left ventricular origin on the efferent activity of cardiac and renal nerves on anaesthetized cats. Basic Res Cardiol 1980; 75: 635645.
Skoog P, Mansson J, Thoren P. Changes in renal sympathetic outflow during hypotensive haemorrhage in rats. Acta Physiol Scand 1985; 125: 655660.
Ullman J. Influence of neurohumoral blockade on heart rate and blood pressure responses to haemorrhage in isoflurane anaesthetized rats. Acta Physiol Scand 2000; 169: 189194.
Saeki Y, Hasegawa Y, Shibamoto T, et al. The effects of sevoflurane, enflurane, and isoflurane on baroreceptor – sympathetic reflex in rabbits. Anesth Analg 1996; 82: 342348.
Muzi M, Ebert TJ. A comparison of baroreflex sensitivity during isoflurane and desflurane anesthesia in humans. Anesthesiology 1995; 82: 919925.

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Desflurane increases heart rate independent of sympathetic activity in dogs

  • O. Picker (a1), L. A. Schwarte (a1), A. W. Schindler (a1) and T. W. L. Scheeren (a1)

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