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Activation of the K+ channel BKCa is involved in the relaxing effect of propofol on coronary arteries

  • A. P. Klockgether-Radke (a1), H. Schulze (a1), P. Neumann (a1) and G. Hellige (a1)

Abstract

Summary

Background and objective: Propofol may cause undesirable hypotension due to vasodilation. The underlying mechanisms are not completely understood. We investigated the mechanisms by which propofol relaxes vascular segments.

Methods: We studied the effect of propofol on isolated porcine coronary artery rings precontracted with potassium chloride or prostaglandin F.

Results: Propofol, in a concentration-dependent manner, relaxed all segments at concentrations of 5 μg mL−1 and above. This relaxation was unaltered in the presence of Nω-nitro-L-arginine, indomethacin, diltiazem and glibenclamide. Tetraethylammonium chloride, an inhibitor of the BKCa K+ channel (a high conductance Ca2+-sensitive K+ channel), dose-dependently attenuated the vasodilating effect of propofol (P < 0.001).

Conclusions: Our results suggests that the activation of the BKCa channel may contribute to the vasodilating effect of propofol, hereby causing hyperpolarization of the smooth muscle membrane and reduction of smooth muscle tone.

Copyright

Corresponding author

Correspondence to: Adelbert Peter Klockgether-Radke, Department of Anaesthesiological Research, Centre of Anaesthesiology, Emergency and Intensive Care Medicine, Georg-August University of Göttingen, Robert-Koch-Strasse 40, D-37075 Göttingen, Germany. E-mail: klockgether-radke@gmx.de; Tel: +49 5561 73066; Fax: +49 5561 73917

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References

Kay B, Rolly G. ICI 35 868, a new intravenous induction agent. Acta Anaesth Belg 1977; 28: 303316.
Goodchild CS, Serrao JM. Cardiovascular effects of propofol in the anaesthetized dog. Br J Anaesth 1989; 63: 8792.
Nakamura K, Hatano Y, Hirakata H, Nishiwada M, Toda H, Mori K. Direct vasoconstrictor and vasodilator effects of propofol in isolated dog arteries. Br J Anaesth 1992; 68: 193197.
Robinson BJ, Ebert TJ, O'Brien TJ, Colinco MD, Muzi M. Mechanisms whereby propofol mediates peripheral vasodilation in humans. Sympathoinhibition or direct vascular relaxation? Anesthesiology 1997; 86: 6472.
Krassioukov AV, Gelb AW, Weaver LC. Action of propofol on central sympathetic mechanisms controlling blood pressure. Can J Anesth 1993; 40: 761769.
Klockgether-Radke AP, Frerichs A, Kettler D, Hellige G. Propofol and thiopental attenuate the contractile response to vasoconstrictors in human and porcine coronary artery segments. Eur J Anaesthesiol 2000; 17: 485490.
Kirkpatrick T, Cockshott ID, Douglas EJ, Nimmo WS. Pharmacokinetics of propofol (Diprivan) in elderly patients. Br J Anaesth 1988; 60: 146150.
Servin F, Desmonts JM, Haberer JP, Cockshott ID, Plummer GF, Farinotti R. Pharmacokinetics and protein binding of propofol in patients with cirrhosis. Anesthesiology 1988; 69: 887891.
Wallerstedt SM, Törnebrandt K, Bodelsson M. Relaxant effects of propofol on human omental arteries and veins. Br J Anaesth 1998; 80: 655659.
Chang KSK, Davis R. Propofol produces endothelium-independent vasodilation and may act as a Ca2+ channel blocker. Anesth Analg 1993; 76: 2432.
Park WK, Lynch C, Johns RA. Effects of propofol and thiopental in isolated rat aorta and pulmonary artery. Anesthesiology 1992; 77: 956963.
Introna RPS, Pruett JK, Yodlowski EH, Grover E. Direct effects of propofol (2,6-diisopropylphenol) on canine coronary artery ring tension. Gen Pharmacol 1993; 24: 497502.
Yamanoue T, Brum JM, Estafanous FG. Vasodilation and mechanisms of action of propofol in porcine coronary arteries. Anesthesiology 1994; 81: 443451.
Gacar N, Gök S, Kalyoncu NI, Özen I, Soykan N, Aktürk G. The effect of endothelium on the response to propofol on bovine coronary artery rings. Acta Anaesth Scand 1995; 39: 10801083.
Park KW, Dai HB, Lowenstein E, Selke FW. Propofol-associated dilation of rat distal coronary arteries is mediated by multiple substances, including endothelium-derived nitric oxide. Anesth Analg 1995; 81: 11911196.
Petros AJ, Bogle RG, Pearson JD. Propofol stimulates nitric oxide release from cultured porcine aortic endothelial cells. Br J Pharmacol 1993; 109: 67.
Horibe M, Ogawa K, Sohn JT, Murray PA. Propofol attenuates acetylcholine-induced pulmonary vasorelaxation: role of nitric oxide and endothelium-derived hyperpolarizing factors. Anesthesiology 2000; 93: 447455.
Yamashita A, Kajikuri J, Ohashi M, Kanmura Y, Itoh T. Inhibitory effects of propofol on acetylcholine-induced, endothelium-dependent relaxation and prostacyclin synthesis in rabbit mesenteric resistance arteries. Anesthesiology 1999; 91: 10801089.
Nagao T, Vanhoutte PM. Endothelium-derived hyperpolarizing factor and endothelium-dependent relaxation. Am J Resp Cell Mol Biol 1993; 8: 16.

Keywords

Activation of the K+ channel BKCa is involved in the relaxing effect of propofol on coronary arteries

  • A. P. Klockgether-Radke (a1), H. Schulze (a1), P. Neumann (a1) and G. Hellige (a1)

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