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Acid–base management during hypothermic neuroprotection

  • Donald C. Whitaker (a1)


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Corresponding author

Correspondence to: Donald Whitaker, Department of Cardiac Surgery, Royal Sussex County Hospital, Brighton, BN2 5BE, UK. E-mail:; Tel: +44 (0)1273 696955 bleep 8464


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Freitsch T, Piepgras A, Krafft P, Schwab S, Kushinsky W, Wasche KF. Editorial: Acid–base management – is it relevant for the study design of hypothermic neuroprotection? Eur J Anaesthesiol 2002; 19: 389394.
Cook DJ, Plochl W, Orszulak TA. Effect of temperature and PaCO2 on cerebral embolization during cardiopulmonary bypass in swine. Ann Thorac Surg 2000; 69: 415420.
Plochl W, Krenn CG, Cook DJ, et al. Can hypocapnia reduce cerebral embolization during cardiopulmonary bypass? Ann Thorac Surg 2001; 72: 845849.
Stephan H, Weyland A, Kazmaier S, Henze T, Menck S, Sonntag H. Acid–base management during hypothermic cardiopulmonary bypass does not affect cerebral metabolism but does affect blood flow and neurological outcome. Br J Anaesth 1992; 69: 5157.
Murkin JM, Martzke JS, Buchan AM, Bentley C, Wong CJ. A randomized study of the influence of perfusion technique and pH management strategy in 316 patients undergoing coronary artery bypass surgery. II. Neurologic and cognitive outcomes. J Thorac Cardiovasc Surg 1995; 110: 349362.
Patel RL, Turtle MR, Chambers DJ, James DN, Newman S, Venn GE. Alpha-stat acid–base regulation during cardiopulmonary bypass improves neuropsychologic outcome in patients undergoing coronary artery bypass grafting. J Thorac Cardiovasc Surg 1996; 111: 12671279.

Acid–base management during hypothermic neuroprotection

  • Donald C. Whitaker (a1)


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