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European Journal of Anaesthesiology European Journal of Anaesthesiology

Article contents

Doxapram and aminophylline on bispectral index under sevoflurane anaesthesia: a comparative study

Published online by Cambridge University Press:  08 August 2006

C.-C. Wu ,
C.-S. Lin ,
G.-J. Wu ,
Y.-H. Lin ,
Y.-W. Lee ,
J.-Y. Chen  and
M. S. Mok
C.-C. Wu
Affiliation:
Taipei Medical University Hospital, Department of Anesthesiology, Taipei, Taiwan, ROC
C.-S. Lin
Affiliation:
Taipei Medical University Hospital, Department of Anesthesiology, Taipei, Taiwan, ROC
G.-J. Wu
Affiliation:
Shin-Kwon Wu Ho Su Memorial Hospital, Department of Anesthesiology, Taipei, Taiwan, ROC
Y.-H. Lin
Affiliation:
Taipei Medical University Hospital, Department of Anesthesiology, Taipei, Taiwan, ROC
Y.-W. Lee
Affiliation:
Taipei Medical University Hospital, Department of Anesthesiology, Taipei, Taiwan, ROC
J.-Y. Chen
Affiliation:
Shin-Kwon Wu Ho Su Memorial Hospital, Department of Anesthesiology, Taipei, Taiwan, ROC
M. S. Mok
Affiliation:
Taipei Medical University Hospital, Department of Anesthesiology, Taipei, Taiwan, ROC
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Abstract

Summary

Background and objective: To evaluate and compare the effect of two clinically available central nervous system stimulants, namely doxapram and aminophylline on arousal from sevoflurane anaesthesia and bispectral index. Methods: This randomized, double-blind, placebo-controlled, prospective study was conducted in 90 adult females, ASA I–II, scheduled for elective lower abdominal surgeries at Taipei Medical University Hospital. At 5 min before the completion of surgery, under sevoflurane anaesthesia, patients were divided into three groups to receive doxapram 1 mg kg−1, aminophylline 2 mg kg−1 or saline placebo intravenous. Standard vital signs, end-tidal CO2, end-expiratory sevoflurane concentration, bispectral index and neuromuscular blockade were measured plus clinical parameters of recovery from general anaesthesia. Results: Compared with the control group, patients receiving doxapram or aminophylline showed a similarly faster recovery from sevoflurane anaesthesia correlated with increase in bispectral index. Conclusion: Intravenous administration of doxapram 1 mg kg−1 or aminophylline 2 mg kg−1 hastened the early recovery from sevoflurane anaesthesia. The arousal effect of aminophylline and doxapram appears to be similar.

Keywords

ANAESTHESIA, GENERAL ANAESTHETICS INHALATIONAL, sevoflurane DOXAPRAM AMINOPHYLLINE
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 23 , Issue 11 , November 2006 , pp. 937 - 941
Copyright
2006 European Society of Anaesthesiology

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References

Sebel PS, Long E, Rampil IJ, et al. A multicenter study of bispectral enlectroencephalographic analysis for monitoring anesthetic effect. Anesth Analg 1997; 84: 891–899.Google Scholar
Glass PS, Bloom M, Kearse L, Rosow C, Sebel P, Manbery P. Bispectral analysis measures sedation and memory effect of propofol, midazolam, isoflurane and alfentanil in healthy volunteers. Anesthesiology 1997; 86: 836–847.Google Scholar
Kissin I. Depth of anaesthesia and bispectral index monitoring. Anesth Analg 2000; 90: 1114–1117.Google Scholar
Turan A, Memis D, Karamanlyodlu CA, Pamukcu Z, Turan N. Effect of aminophylline on recovery from sevoflurane anaesthesia. Eur J Anaesthsiol 2002; 19: 452–454.Google Scholar
Turan A, Memis D, Karamanlyodlu B, Pamukcu Z, Sur N. Effect of aminophylline on bispectral index. Acta Anaesthsiol Scand 2004; 48: 408–411.Google Scholar
Aldrete JA, Kroulik D. A postanesthetic recovery score. Anesth Analg 1970; 49: 924–934.Google Scholar
Mi WD, Saki T, Takahashi S, Matsuki A. Haemodynamic and electroencephalography response to intubation during induction with propofol or propofol/fentanyl. Can J Anaesth 1998; 45: 19–22.Google Scholar
Flaishon R, Windsor A, Sigl J, Sebel PS. Recovery of consciousness after thiopental or propofol. Bispectral index and isolated forearm technique. Anesthesiology 1997; 86: 613–619.Google Scholar
Song D, Joshi GP, White PF. Titration of volatile anesthetics using bispectral index facilitates recovery after ambulatory anaesthesia. Anesthesiology 1997; 87: 842–848.Google Scholar
Hans P, Dewandre PY, Brichant JF, Bonhomme V. Comparative effects of ketamine on bispectral index and spectral entropy of the electroencephalogram under sevoflurane anaesthesia. Br J Anaesth 2005; 94: 336–340.Google Scholar
Sakai T, Singh H, Mi WD, Kudo T, Matsuki A. The effect of ketamine on clinical endpoints of hypnosis and EEG variables during propofol infusion. Acta Anaesthsiol Scand 1999; 42: 212–216.Google Scholar
Puri GD. Paradoxical changes in bispectral index during nitrous oxide administration. Br J Anaesth 2001; 86: 141–142.Google Scholar
Rampil IJ, Kim JS, Lenhardt R, Negishi C, Sessler DJ. Bispectral EEG index during nitrous oxide administration. Anesthesiology 1998; 89: 671–677.Google Scholar
Goto T, Nakata Y, Saito H, et al. Bispectral analysis of the electroencephalogram does not predict responsiveness to verbal command in patients emerging from xenon anaesthesia. Br J Anaesth 2000; 85: 359–363.Google Scholar
Meuret P, Backman SB, Bonhomme V, Plourde G, Fiset P. Physostigmine reverses propofol-induced unconsciousness and attenuation of the auditory steady state response and bispectral index in human volunteers. Anesthesiology 2000; 93: 708–717.Google Scholar
Ward JW, Franko BV. A new centrally acting agent (AHR-619) with marked respiratory stimulant, pressor and awakening effects. Fed Proc 1962; 21: 325.Google Scholar
Kato H, Buckley JP. Possible site of action of the respiratory stimulant effect of doxapram hydrochloride. J Pharmacol Exp Ther 1964; 144: 260–264.Google Scholar
Scott RM, Whitman JG, Charkrabarti MK. Evidence of a role for peripheral chemoreceptors in the ventilatory response to doxapram in man. Br J Anaesth 1977; 49: 227–231.Google Scholar
Po BT, Watson RL, Hansen HR. Arousal time following intravenous agents methohexital and thiopental: effect of doxapram hydrochloride. Anesth Analg 1968; 47: 446–451.Google Scholar
Gupta PK, Dundee JW. Hastening arousal after general anaesthesia with doxapram hydrochloride. Br J Anaesth 1973; 45: 493–496.Google Scholar
Riddle PL, Robertson GS. Use of doxapram as an arousal agent in outpatient general anaesthesia. Br J Anaesth 1978; 50: 921–924.Google Scholar
Butcher RW, Sutherland EW. Adenosine 3,5 phosphate in biological materials. J Biol Chem 1962; 237: 1244–1250.Google Scholar
Sawynok J, Jhamandas KH. Inhibition of acetylcholine release from cholinergic nerves by adenosine, adenine nucleotides and morphine; antagonism by theophylline. J Pharmacol Exp Ther 1976; 197: 379–390.Google Scholar
Porkka-Heiskanen T. Adenosine in sleep and wakefulness. Ann Med 1999; 31: 125–129.Google Scholar
Alanko LO, Laitinen JT, Stenberg D, Porkka-Heiskanen T. Adenosine A1 receptor-dependent G-protein activity in the rat brain during prolonged wakefulness. Neuroreport 2004; 15: 2133–2137.Google Scholar
Marrosu F, Marchi A, De Martino MR, Saba G, Gessa GL. Aminophylline antagonizes diazepam-induced anaesthesia and EEG changes in humans. Psychopharmacology 1985; 85: 69–70.Google Scholar
Krintel JJ, Wegmann F. Aminophylline reduces the depth and duration of sedation with barbiturates. Acta Anaesthesiol Scand 1987; 31: 352–354.Google Scholar
Sakurai S, Fukunaga AF, Kobayashi Y, Ichinoche T, Kaneko Y. Aminophylline reduces recovery time from isoflurane/nitrous oxide anaesthesia. Anesthesiology 1998; 89: A351.Google Scholar

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Doxapram and aminophylline on bispectral index under sevoflurane anaesthesia: a comparative study
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