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Doxapram and aminophylline on bispectral index under sevoflurane anaesthesia: a comparative study

Published online by Cambridge University Press:  08 August 2006

C.-C. Wu
Affiliation:
Taipei Medical University Hospital, Department of Anesthesiology, Taipei, Taiwan, ROC
C.-S. Lin
Affiliation:
Taipei Medical University Hospital, Department of Anesthesiology, Taipei, Taiwan, ROC
G.-J. Wu
Affiliation:
Shin-Kwon Wu Ho Su Memorial Hospital, Department of Anesthesiology, Taipei, Taiwan, ROC
Y.-H. Lin
Affiliation:
Taipei Medical University Hospital, Department of Anesthesiology, Taipei, Taiwan, ROC
Y.-W. Lee
Affiliation:
Taipei Medical University Hospital, Department of Anesthesiology, Taipei, Taiwan, ROC
J.-Y. Chen
Affiliation:
Shin-Kwon Wu Ho Su Memorial Hospital, Department of Anesthesiology, Taipei, Taiwan, ROC
M. S. Mok
Affiliation:
Taipei Medical University Hospital, Department of Anesthesiology, Taipei, Taiwan, ROC
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Abstract

Summary

Background and objective: To evaluate and compare the effect of two clinically available central nervous system stimulants, namely doxapram and aminophylline on arousal from sevoflurane anaesthesia and bispectral index. Methods: This randomized, double-blind, placebo-controlled, prospective study was conducted in 90 adult females, ASA I–II, scheduled for elective lower abdominal surgeries at Taipei Medical University Hospital. At 5 min before the completion of surgery, under sevoflurane anaesthesia, patients were divided into three groups to receive doxapram 1 mg kg−1, aminophylline 2 mg kg−1 or saline placebo intravenous. Standard vital signs, end-tidal CO2, end-expiratory sevoflurane concentration, bispectral index and neuromuscular blockade were measured plus clinical parameters of recovery from general anaesthesia. Results: Compared with the control group, patients receiving doxapram or aminophylline showed a similarly faster recovery from sevoflurane anaesthesia correlated with increase in bispectral index. Conclusion: Intravenous administration of doxapram 1 mg kg−1 or aminophylline 2 mg kg−1 hastened the early recovery from sevoflurane anaesthesia. The arousal effect of aminophylline and doxapram appears to be similar.

Type
Original Article
Copyright
2006 European Society of Anaesthesiology

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Doxapram and aminophylline on bispectral index under sevoflurane anaesthesia: a comparative study
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