Hostname: page-component-848d4c4894-xfwgj Total loading time: 0 Render date: 2024-06-23T02:49:21.294Z Has data issue: false hasContentIssue false

A review of the effects of environmental pollution on the equine respiratory tract: considerations for the 2004 Athens Olympic Games

Published online by Cambridge University Press:  09 March 2007

CM Deaton*
Affiliation:
Animal Health Trust, Lanwades Park, Kentford, Suffolk, CB8 7UU, UK
DJ Marlin
Affiliation:
Animal Health Trust, Lanwades Park, Kentford, Suffolk, CB8 7UU, UK
Get access

Abstract

Chemical pollutants, for example ozone, have been demonstrated to have detrimental effects on the cardiorespiratory system in human beings. Inhalation of pollutants may therefore impact on the performance of athletes at the 2004 Athens Olympic Games. Horses will also be exposed to these pollutants contained within the large volume of air they inhale during exercise. Opportunely, the equine events will be staged outside of Athens and as a result the concentration of atmospheric chemical pollutants is likely to be lower than that experienced by many of the human athletes. The horses' housing environment should also be carefully considered as a source of pollutants, as certain bedding materials can release dust, mould spores and irritants that may induce airway inflammation. In order to achieve the highest level of performance it is essential that both horse and rider be in good health and therefore the influence of environmental pollutants on lung function should to be minimized.

Type
Research Article
Copyright
Copyright © Cambridge University Press 2004

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Mazan, MR, Ghio, AJ and Hoffman, AM (2001). Airway reactivity, inflammation, iron and iron-binding proteins in horses from urban versus rural environments. In: World Equine Airways Symposium, Edinburgh. Abstract p. 31.Google Scholar
2Kamp, DW, Israbian, VA, Preusen, SE, Zhang, CX and Weitzman, SA (1995). Asbestos causes DNA strand breaks in cultured pulmonary epithelial cells: role of iron-catalyzed free radicals. American Journal of Physiology 268: L471L480.Google ScholarPubMed
3Pierson, WE, Covert, DS, Koenig, JQ, Namekata, T and Kim, YS (1986). Implications of air pollution effects on athletic performance. Medicine and Science in Sports and Exercise 18: 322327.CrossRefGoogle ScholarPubMed
4Frampton, MW, Boscia, J, Roberts, NJ Jr, Azadniv, M, Torres, A, Cox, C et al. (2002). Nitrogen dioxide exposure: effects on airway and blood cells. American Journal of Physiology. Lung, Cell and Molecular Physiology 282: L155L165.CrossRefGoogle ScholarPubMed
5Hazucha, MJ, Folinsbee, LJ, Seal, E and Bromberg, PA (1994). Lung function response of healthy women after sequential exposures to NO2 and O3. American Journal of Respiratory and Critical Care Medicine 150: 642647.CrossRefGoogle ScholarPubMed
6Mudway, IS and Kelly, FJ (2000). Ozone and the lung: a sensitive issue. Molecular Aspects of Medicine 21: 148.CrossRefGoogle Scholar
7Saitanis, CJ (2003). Background ozone monitoring and phytodetection in the greater rural area of Corinth–Greece. Chemosphere 51: 913923.CrossRefGoogle ScholarPubMed
8Romieu, I, Meneses, F, Sienra-Monge, JJ, Huerta, J, Ruiz Velasco, S, White, MC et al. (1995). Effects of urban air pollutants on emergency visits for childhood asthma in Mexico City. American Journal of Epidemiology 141: 546553.CrossRefGoogle ScholarPubMed
9Schwartz, J (1994). Air pollution and hospital admissions for the elderly in Detroit, Michigan. American Journal of Respiratory and Critical Care Medicine 150: 648655.CrossRefGoogle ScholarPubMed
10Pryor, WA, Das, B and Church, DF (1991). The ozonation of unsaturated fatty acids: aldehydes and hydrogen peroxide as products and possible mediators of ozone toxicity. Chemical Research in Toxicology 4: 341348.CrossRefGoogle ScholarPubMed
11Langford, SD, Bidani, A and Postlethwait, EM (1995). Ozonereactive absorption by pulmonary epithelial lining fluid constituents. Toxicology and Applied Pharmacology 132: 122130.CrossRefGoogle ScholarPubMed
12Pryor, WA, Squadrito, GL and Friedman, M (1995). A new mechanism for the toxicity of ozone. Toxicology Letters 8283: 287293.CrossRefGoogle ScholarPubMed
13Haddad, JJ (2002). Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidantmediated lung injury: role for nuclear factor-kappaB. Critical Care 6: 481490.CrossRefGoogle ScholarPubMed
14Misawa, M and Nakano, E (1993). Airway constriction by xanthine/xanthine oxidase in guinea pigs in vivo. Journal of Toxicology and Environmental Health 39: 193205.CrossRefGoogle ScholarPubMed
15Deaton, CM, Marlin, DJ, Roberts, CA, Smith, N, Harris, PA, Kelly, FJ et al. (2002). Antioxidant supplementation and pulmonary function at rest and exercise. Equine Veterinary Journal Supplement 34: 5865.CrossRefGoogle Scholar
16Mills, PC, Roberts, CA and Smith, NC (1996). Effects of ozone and airway inflammation on glutathione status and iron homeostasis in the lungs of horses. American Journal of Veterinary Research 57: 13591363.CrossRefGoogle ScholarPubMed
17Deaton, CM, Marlin, DJ, Smith, NC, Harris, PA, Roberts, CA, Schroter, RC et al. (2004). Pulmonary epithelial lining fluid and plasma ascorbic acid concentrations in horses affected by recurrent airway obstruction. American Journal of Veterinary Research 65: 8087.CrossRefGoogle ScholarPubMed
18Kleeberger, SR (1995). Genetic susceptibility to ozone exposure. Toxicology Letters 82-83: 295300.CrossRefGoogle ScholarPubMed
19Kreit, JW, Gross, KB, Moore, TB, Lorenzen, TJ, D'Arcy, J and Eschenbacher, WL (1989). Ozone-induced changes in pulmonary function and bronchial responsiveness in asthmatics. Journal of Applied Physiology 66: 217222.CrossRefGoogle ScholarPubMed
20Scannell, C, Chen, L, Aris, RM, Tager, I, Christian, D, Ferrando, R et al. (1996). Greater ozone-induced inflammatory responses in subjects with asthma. American Journal of Respiratory and Critical Care Medicine 154: 2429.CrossRefGoogle ScholarPubMed
21Basha, MA, Gross, KB, Gwizdala, CJ, Haidar, AH and Popovich, J Jr (1994). Bronchoalveolar lavage neutrophilia in asthmatic and healthy volunteers after controlled exposure to ozone and filtered purified air. Chest 106: 17571765.CrossRefGoogle ScholarPubMed
22Bosson, J, Stenfors, N, Bucht, A, Helleday, R, Pourazar, J, Holgate, ST et al. (2003). Ozone-induced bronchial epithelial cytokine expression differs between healthy and asthmatic subjects. Clinical and Experimental Allergy 33: 777782.CrossRefGoogle ScholarPubMed
23Stenfors, N, Pourazar, J, Blomberg, A, Krishna, MT, Mudway, I, Helleday, R et al. (2002). Effect of ozone on bronchial mucosal inflammation in asthmatic and healthy subjects. Respiratory Medicine 96: 352358.CrossRefGoogle ScholarPubMed
24Mudway, IS, Stenfors, N, Blomberg, A, Helleday, R, Dunster, C, Marklund, SL et al. (2001). Differences in basal airway antioxidant concentrations are not predictive of individual responsiveness to ozone: a comparison of healthy and mild asthmatic subjects. Free Radical Biology & Medicine 31: 962974.CrossRefGoogle Scholar
25Balmes, JR, Chen, LL, Scannell, C, Tager, I, Christian, D, Hearne, PQ et al. (1996). Ozone-induced decrements in FEV1 and FVC do not correlate with measures of inflammation. American Journal of Respiratory and Critical Care Medicine 153: 904909.CrossRefGoogle Scholar
26Blomberg, A, Mudway, IS, Nordenhall, C, Hedenstrom, H, Kelly, FJ, Frew, AJ et al. (1999). Ozone-induced lung function decrements do not correlate with early airway inflammatory or antioxidant responses. European Respiratory Journal 13: 14181428.CrossRefGoogle ScholarPubMed
27Crapo, JD, Barry, BE, Chang, LY and Mercer, RR (1984). Alterations in lung structure caused by inhalation of oxidants. Journal of Toxicology and Environmental Health 13: 301321.CrossRefGoogle ScholarPubMed
28Nevalainen, M, Raulo, SM, Brazil, TJ, Pirie, RS, Sorsa, T, McGorum, BC et al. (2002). Inhalation of organic dusts and lipopolysaccharide increases gelatinolytic matrix metalloproteinases (MMPs) in the lungs of heaves horses. Equine Veterinary Journal 34: 150155.CrossRefGoogle ScholarPubMed
29Johnson, DA (1980). Ozone inactivation of human alpha 1-proteinase inhibitor. American Review of Respiratory Disease 121: 10311038.Google ScholarPubMed
30Kirschvink, N, Fievez, L, Bureau, F, Degand, G, Maghuin-Rogister, G, Smith, N et al. (2002). Adaptation to multiday ozone exposure is associated with a sustained increase of bronchoalveolar uric acid. Free Radical Research 36: 2332.CrossRefGoogle ScholarPubMed
31van Bree, L, Dormans, JA, Koren, HS, Devlin, RB and Rombout, PJ (2002). Attenuation and recovery of pulmonary injury in rats following short-term, repeated daily exposure to ozone. Inhalation Toxicology 14: 883900.CrossRefGoogle ScholarPubMed
32Silverman, F, Folinsbee, LJ, Barnard, J and Shephard, RJ (1976). Pulmonary function changes in ozone-interaction of concentration and ventilation. Journal of Applied Physiology 41: 859864.CrossRefGoogle ScholarPubMed
33Nodelman, V and Ultman, JS (1999). Longitudinal distribution of chlorine absorption in human airways: a comparison to ozone absorption. Journal of Applied Physiology 87: 20732080.CrossRefGoogle ScholarPubMed
34Santiago, LY, Hann, MC, Ben-Jebria, A and Ultman, JS (2001). Ozone absorption in the human nose during unidirectional airflow. Journal of Applied Physiology 91: 725732.CrossRefGoogle ScholarPubMed
35Tyler, W, Jones, J, Birks, E, Pascoe, J, Steffey, E, Jarvis, K et al. (1991). Effects of ozone on exercising horses: a preliminary report. Equine Exercise Physiology 3: 490502.Google Scholar
36Foxcroft, WJ and Adams, WC (1986). Effects of ozone exposure on four consecutive days on work performance and VO2max. Journal of Applied Physiology 61: 960966.CrossRefGoogle ScholarPubMed
37Pirie, RS, Collie, DD, Dixon, PM and McGorum, BC (2003). Inhaled endotoxin and organic dust particulates have synergistic proinflammatory effects in equine heaves (organic dust-induced asthma). Clinical and Experimental Allergy 33: 676683.CrossRefGoogle ScholarPubMed
38McGorum, BC, Dixon, PM and Halliwell, RE (1993). Responses of horses affected with chronic obstructive pulmonary disease to inhalation challenges with mould antigens. Equine Veterinary Journal 25: 261267.CrossRefGoogle ScholarPubMed
39Art, T, Duvivier, DH, Votion, D, Anciaux, N, Vandenput, S, Bayly, WM et al. (1998). Does an acute COPD crisis modify the cardiorespiratory and ventilatory adjustments to exercise in horses?” Journal of Applied Physiology 84: 845852.CrossRefGoogle ScholarPubMed
40Robinson, NE (2001). International Workshop on Equine Chronic Airway Disease Michigan State University 16–18 June 2000. Equine Veterinary Journal 33: 519.CrossRefGoogle ScholarPubMed
41Bracher, V, von Fellenberg, R, Winder, CN, Gruenig, G, Hermann, M and Kraehenmann, A (1991). An investigation of the incidence of chronic obstructive pulmonary disease (COPD) in random populations of Swiss horses. Equine Veterinary Journal 23: 136141.CrossRefGoogle ScholarPubMed
42McGorum, BC, Ellison, J and Cullen, RT (1998). Total and respirable airborne dust endotoxin concentrations in three equine management systems. Equine Veterinary Journal 30: 430434.CrossRefGoogle ScholarPubMed
43Mazan, M and Hoffman, A (2003). In: Hoffman, A, Robinson, NE and Wade, JF (eds), Inflammatory Airway Disease: Effect of Athletic Discipline. Newmarket, UK: R&W Publications (Newmarket) Limited, Havemeyer Foundation Monograph Series No. 9, pp. 912.Google Scholar
44Couetil, LL and Denicola, DB (1999). Blood gas, plasma lactate and bronchoalveolar lavage cytology analyses in racehorses with respiratory disease. Equine Veterinary Journal Supplement 30: 7782.CrossRefGoogle Scholar
45Newton, JR and Wood, JL (2002). Evidence of an association between inflammatory airway disease and EIPH in young Thoroughbreds during training. Equine Veterinary Journal Supplement 34: 417424.CrossRefGoogle Scholar
46Rapp, HJ, Bockisch, FJ, Weiss, R, Becker, M, Stechele, M and Heisse, K (1992). Riding arenas and different riding track surfaces in relation to the airway contamination in horses. Laboratory studies on riding surfaces. Tierarztliche Praxis 20: 503508.Google Scholar
47Katayama, Y, Oikawa, M, Yoshihara, T, Kuwano, A and Hobo, S (1995). Clinico-pathological effects of atmospheric ammonia exposure on horses. Journal of Equine Science 6: 99104.CrossRefGoogle Scholar
48Tanner, MK, Swinker, AM, Traub-Dargatz, JL, Stiffler, LA, McCue, PM, Vanderwall, DK et al. (1998). Respiratory and environmental effects of recycled phone book paper versus sawdust as bedding for horses. Journal of Equine Veterinary Science 18: 468476.CrossRefGoogle Scholar
49Kobzik, L, Huang, S, Paulauskis, JD and Godleski, JJ (1993). Particle opsonization and lung macrophage cytokine response. In vitro and in vivo analysis. Journal of Immunology 151: 27532759.CrossRefGoogle ScholarPubMed