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The relationship among Mental Health Status (GHQ-12), Health Related Quality of Life (EQ-5D) and Health-State Utilities in a general population

  • Pedro Serrano-Aguilar (a1) (a2), Yolanda Ramallo-Fariña (a2) (a3), Maria Del Mar Trujillo-Martín (a3), Sergio Raul Muñoz-Navarro (a4), Lilisbeth Perestelo-Perez (a1) (a2) and Carlos De Las Cuevas-Castresana (a2) (a5)...

Summary

Aim – To assess the relationship between mental health and health-related quality of life (HRQL) in the general population, and to map GHQ-12 as a screening test for population psychological distress to a generic health state measure (EQ-5D) in order to estimate health state values and allow deriving quality-adjusted life years. Methods – Relationship between mental health and HRQL was examined from the 2004 Canary Islands’ Health Survey. Participants were classified as probable psychiatric cases according to GHQ-12. HRQL was measured by the EQ-5D index. Multivariate lineal regression analysis was used to examine the association between mental health and HRQL adjusting by socio-demographic variables and comorbidities. A multivariate regression model was built from EQ-5D to estimate health states values using GHQ-12 as exposure. Results – EQ-5D index scores decreased as the GHQ-12 scores increased. Clinical and socio-demographic factors influenced HRQL without changing the overall trend for this negative relationship. The regression equation explained 43% of the variance. For estimation of utility scores, the model showed a high predictive capacity, with a mean forecast errors of 16%. Conclusions – HRQL progressively decreased when the probability of being a psychiatric case increased. Findings enable health state values to be derived from GHQ-12 scores for populations where utilities has not or cannot be measured directly.

Declaration of Interest: Authors declare no conflicts of interest. This work was supported by the Quality Plan for the National Health Service (Spanish Ministry of Health and Social Policy).

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Corresponding author

Address for correspondence: Dr. Ma del Mar Trujillo Martìn, Servicio Canario de la Salud. Pérez de Rozas 5, 4°. 38004 Santa Cruz de Tenerife (Spain). Fax: +34-922-475751 E-mail: matrumar@gobiernodecanarias.org

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