Skip to main content Accessibility help
Hostname: page-component-78dcdb465f-nbrzn Total loading time: 0.387 Render date: 2021-04-16T02:37:59.048Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": false, "newCiteModal": false, "newCitedByModal": true }

The connection of depression and heart disease and its implications

Published online by Cambridge University Press:  11 October 2011

Rights & Permissions[Opens in a new window]


Image of the first page of this article. For PDF version, please use the ‘Save PDF’ preceeding this image.
Copyright © Cambridge University Press 2002


Ahern, D., Gorkin, L., Anderson, J., Tierney, C, Hallstrom, A., Ewart, C, Capone, R.J., Schron, E., Kornfeid, D., Herd, J.A. et al. (1990). Biobehavioral variables and mortality or cardiac arrest in the Cardiac Arrhythmia Pilot Study (CAPS). American Journal of Cardiology 66, 5962.CrossRefGoogle Scholar
Alderman, M.H. & Schoenbaum, E.E. (1975). Detection and treatment of hypertension at the worksite. New England Journal of Medicine 293, 6568.CrossRefGoogle Scholar
Alderman, M.H., Madhavan, S., Ooi, W.L., Cohen, H., Sealey, J.E. & Laragh, J.H. (1991). Association of the renin-sodium profile with the risk of myocardial infarction in patients with hypertension. New England Journal of Medicine 324, 10981104.CrossRefGoogle ScholarPubMed
Anda, R., Williamson, D., Jones, D., Macera, C, Eaker, E., Glassman, A. & Marks, J. (1993). Depressed affect, hopelessness, and the risk of ischemic heart disease in a cohort of U.S. adults. Epidemiology 4, 285294.CrossRefGoogle Scholar
Aromaa, A., Raitasalo, R., Reunanen, A., Impivaara, O., Heliovaara, M., Knekt, P., Lehtinen, V.Joukamaa, M. & Maatela, J. (1994). Depression and cardiovascular diseases. Ada Psychiatrica Scandinavica, Supplementum No. 377, 7782.CrossRefGoogle ScholarPubMed
Barefoot, J.C. & Schroll, M. (1996). Symptoms of depression, acute myocardial infarction, and total mortality in a community sample. Circulation 93, 19761980.CrossRefGoogle Scholar
Berkman, L.F. & Jaffe, A.S., for the ENRICHD Investigators (2001) The effects of treating depression and low social support on clinical events after a myocardial infarction (Abstract). Circulation 2001 104(25), IB.Google Scholar
Bingefors, K., Isacson, D., Von Knorring, L., Smedby, B. &Wicknertz, K. (1996). Antidepressant-treated patients in ambulatory care. Mortality during a nine-year period after first treatment. British Journal of Psychiatry 169, 647654.CrossRefGoogle ScholarPubMed
Carney, R.M., Rich, M.W., Freedland, K.E., Saini, J., teVelde, A., Simeone, C. & Clark, K. (1988). Major depressive disorder predicts cardiac events in patients with coronary artery disease. Psychosomatic Medicine 50, 627633.CrossRefGoogle ScholarPubMed
Carney, R.M., Saunders, R.D., Freedland, K.E., Stein, P., Rich, M.W. & Jaffe, A.S. (1995a). Association of depression with reduced heart rate variability in coronary artery disease. American Journal of Cardiology 76, 562564.CrossRefGoogle ScholarPubMed
Carney, R.M., Rich, M.W. & Jaffe, A.S. (1995b). Depression as a risk factor for cardiac events in established coronary heart disease: a review of possible mechanisms. Annals of Behavioral Medicine 17, 142149.CrossRefGoogle ScholarPubMed
Cohen, H.W., Gibson, G. & Alderman, M.H. (2000). Excess risk of myocardial infarction in patients treated with antidepressant medications: association with use of tricyclic agents. American Journal of Medicine 108, 28.CrossRefGoogle ScholarPubMed
Cohen, H.W., Madhavan, S. & Alderman, M.N. (2001a). History of treatment for depression: risk factor for myocardial infarction in hypertensive patients. Psychosomatic Medicine 63, 203209.CrossRefGoogle ScholarPubMed
Cohen, H.W., Madhavan, S. & Alderman, M.H. (2001b). High and low serum potassium associated with cardiovascular events in diuretictreated patients. Journal of Hypertension 19, 13151323.CrossRefGoogle ScholarPubMed
ENRICHD Investigators (2000). Enhancing recovery in coronary heart disease (ENRICHD): study design and methods. American Heart Journal 139(1), 19.CrossRefGoogle Scholar
Everson, S.A., Kaplan, G.A., Goldberg, D.E., Salonen, R. & Salonen, J.T. (1997). Hopelessness and 4-year progression of carotid atherosclerosis. Arteriosclerosis and Thrombosis 17, 14901495.CrossRefGoogle ScholarPubMed
Ford, D.E., Mead, L.A., Chang, P.P., Cooper-Patrick, L., Wang, N.Y. & Klag, M.J. (1998). Depression is a risk factor for coronary artery disease in men: the Precursors Study. Archives of Internal Medicine 158, 14221426.CrossRefGoogle ScholarPubMed
Frasure-Smith, N., Lesperance, F. & Talajic, M. (1995). Depression and 18-month prognosis after myocardial infarction. Circulation 91(4), 9991005.CrossRefGoogle ScholarPubMed
Glassman, A.H. (1998). Depression andd the course of coronary artery disease. American Journal of Psychiatry 155, 411.CrossRefGoogle Scholar
Lapane, K.L., Zierler, S., Lasater, T.M., Barbour, M.M., Carleton, R. & Hume, A.L. (1995). Is the use of psychotropic drugs associated with increased risk of ischemic heart disease? Epidemiology 6(4), 376381.CrossRefGoogle ScholarPubMed
Musselman, D.L., Tomer, A., Manatunga, A.K., Knight, B.T., Porter, M.R., Kasey, S., Marzic, U, Harker, L.A. & Nemeroff, C.G. (1996). Exaggerated platelet reactivity in major depression. American Journal of Psychiatry 153, 13131317.Google ScholarPubMed
Nemeroff, C.B. & Musselman, D.L. (2000). Are platelets the link between depression and ischemic heart disease? American Heart Journal 140, Suppl. 4, 5762.CrossRefGoogle Scholar
O'Connor, C.M., Glassman, A.H., Harrison, W.M., for the SADHART Investigators (2001). A randomized double-blind placebo controlled trial of the selective serotonin reuptake inhibitor (SSRI) sertraline for major depression after acute coronary syndromes (ACS). In The SADHART Trial. American Heart Association Scientific Sessions 2001, Nov. 11, 2001 Abstract 102513, Anaheim, California.Google Scholar
Penninx, B.W., Beekman, A.T., Honig, A., Deeg, D.J., Schoevers, R.A., van Eijk, J.T. & Tilbur, van. Depression and cardiac mortality: results from a community-based longitudinal study. Archives of General Psychiatry 58(3), 229230.Google Scholar
Pratt, L.A., Ford, D.E., Crum, R.M., Armenian, H.K., Gallo, J.J. & Eaton, W.W. (1996). Depression, psychotropic medication, and risk of myocardial infarction: prospective data from the Baltimore ECA follow-up. Circulation 94, 31233129.CrossRefGoogle ScholarPubMed
Roose, S.P., Laghrissi-Thode, F., Kennedy, J.S. et al. , (1998). Comparison of paroxetine and nortriptyline in depressed patients with ischemic heart disease. Journal of the American Medical Association 279, 287291.CrossRefGoogle ScholarPubMed
Sauer, W.H., Berlin, J.A. & Kimmel, S.E. (2001). Selective serotonin reuptake inhibitors and myocardial infarction. Circulation 104(16), 18941898.CrossRefGoogle ScholarPubMed
Sesso, H.D., Kawachi, I., Vokonan, P.S. & Sparrow, D. (1998). Depression and the risk of coronary heart disease in the Normative Aging Study. American Journal of Cardiology 82(7), 851856.CrossRefGoogle ScholarPubMed
Shapiro, P.A., Lesperance, F., Frasure-Smith, N., O'Connor, C.M., Baker, B., Jiang, W., Dorian, P., Harrison, W. & Glassman, A.H. (1999). An open-label preliminary trial of sertraline for treatment of major depression after acute myocardial infarction (the SADHART Trial). Sertraline Anti-Depression Heart Attack Trial. American Heart Journal 137, 11001106.CrossRefGoogle Scholar
Thomas, C, Kelman, H.R., Kennedy, G.J., Ahn, C & Yang, C (1992). Depressive symptoms and mortality in elderly persons. Journal of Gerontology 47(2), S80–S87.CrossRefGoogle ScholarPubMed
Vogt, T., Pope, C, Mullooly, J. & Hollis, J. (1994). Mental health status as a predictor of morbidity and mortality: a 15-year follow-up of members of a health maintenance organization. American Journal of Public Health 84, 227231.CrossRefGoogle ScholarPubMed
Wassertheil-Smoller, S., Applegate, W.B., Berge, K., Chang, C.J., Davis, B.R., Grimm, R. Jr, Kostis, J., Pressel, S. & Schron, E. (1996). Change in depression as a precursor of cardiovascular events. Arclu'ves of Internal Medicine 156, 553561.CrossRefGoogle ScholarPubMed

Full text views

Full text views reflects PDF downloads, PDFs sent to Google Drive, Dropbox and Kindle and HTML full text views.

Total number of HTML views: 0
Total number of PDF views: 130 *
View data table for this chart

* Views captured on Cambridge Core between September 2016 - 16th April 2021. This data will be updated every 24 hours.

You have Access

Send article to Kindle

To send this article to your Kindle, first ensure is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the or variations. ‘’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

The connection of depression and heart disease and its implications
Available formats

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

The connection of depression and heart disease and its implications
Available formats

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

The connection of depression and heart disease and its implications
Available formats

Reply to: Submit a response

Your details

Conflicting interests

Do you have any conflicting interests? *