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The post partum as specific risk factor for the onset of obsessive-compulsive disorder: clinical- controlled study

Published online by Cambridge University Press:  11 October 2011

Giuseppe Maina
Affiliation:
Dipartimento di Neuroscienze, Servizio per i disturbi depressivi e d'ansia, Università degli Studi di Torino
Patrizia Vaschetto
Affiliation:
Dipartimento di Neuroscienze, Servizio per i disturbi depressivi e d'ansia, Università degli Studi di Torino
Simona Ziero
Affiliation:
Dipartimento di Neuroscienze, Servizio per i disturbi depressivi e d'ansia, Università degli Studi di Torino
Rossella Di Lorenzo
Affiliation:
Dipartimento di Neuroscienze, Servizio per i disturbi depressivi e d'ansia, Università degli Studi di Torino
Filippo Bogetto
Affiliation:
Dipartimento di Neuroscienze, Servizio per i disturbi depressivi e d'ansia, Università degli Studi di Torino
Corresponding

Summary

Objective – The aim of this study is to evaluate the presence of triggering life-events for the onset of Obsessive–Compulsive Disorder in women (OCD). Design – Clinical controlled study. Setting – Service for depressive and anxiety disorders; Department of Neuroscience, Psichiatric Unit, University of Turin. Methods – The study compares twenthy-nine women with OCD (DSM-IV criteria) with twenthy–nine healthy control women matched for demographic features and with twenthy-ni– ne women with Bulimia Nervosa (DSM-IV criteria) matched for age, age at onset, education and marital status. All patients were assessed with the Clinical Structured Interview for DSMIII-R (SCID) and with the Interview for Recent Life Event by Paykel. Moreover, OCD patients were assessed with the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and bulimic patients with the Eating Disorder Inventory (EDI). Results – The study demonstrates that the only specific life event that is significantly associated with the onset of OCD is “having a new born child” No significant differences in frequency and severity of stressing life events were found in the three groups. Conclusions – The results confirms the findings of our previous study: post partum is the only risk factor for the onset of OCD in female population, compared to healthy control. Furthermore, this research points-out the importance and the specificity of this association showing that post partum is not a risk factor in all psychiatric disorders.

Riassunto

Scopo – Lo studio si propone di indagare, tra gli eventi psicosociali stressanti, l'esistenza di un fattore di rischio specifico per l'esordio del disturbo ossessivo-compulsivo nelle donne (DOC). Disegno – Studio clinico controllato. Setting – Servizio per i disturbi depressivi e d'ansia, Clinica Psichiatrica, Università di Torino. Metodo – Sono state inserite nella ricerca 29 pazienti di sesso femminile con diagnosi attuale di DOC secondo i criteri del DSM-IV. Tale popolazione è stata confrontata con 2 gruppi di controllo: 29 donne sane appaiate per caratteristiche sociodemografiche alle pazienti ossessive e 29 pazienti di sesso femminile con diagnosi attuale di bulimia nervosa appaiate per età, età d'esordio, scolarita e stato civile al gruppo di studio. A tutte le donne incluse nell'indagine è stata somministrata l'lntervista Clinica Strutturata per il DSM III-R (SCID) per la valutazione dei disturbi di Asse I e I'Interview for Recent Life Event di Paykel per I'individuazione dei life-events nei 12 mesi precedenti l'esordio del disturbo (e negli ultimi 12 mesi per le donne sane). Inoltre, alle pazienti ossessive è stata somministrata la Yale- Brown Obsessive Compulsive Scale (Y-BOCS) e alle pazienti bulimiche la Eating Disorder Inventory(EDI). Risultati – Sia la frequenza che la gravità degli eventi psicosociali stressanti non sono risultate significativamente differenti nei tre gruppi. La valutazione della prevalenza dei singoli eventi ha messo in evidenza che il life-event “nascita di un figlio vivo per la madre” era significativamente più frequente nelle pazienti ossessive. Conclusioni – Lo studio ribadisce in primo luogo quanto avevamo osservato in una precedente ricerca: tra gli eventi psicosociali stressanti, riscontrati nell'anno precedente l'insorgenza del DOC, solo il post partum costituisce un fattore di rischio per l'esordio del disturbo nella popolazione femminile rispetto ai controlli sani. In secondo luogo, tale ricerca porta ulteriori evidenze a favore dell'importanza e specificità di questa associazione, mostrando che non in tutte le patologie psichiatriche il post partum è un fattore di rischio per l'esordio.

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Copyright
Copyright © Cambridge University Press 2001

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References

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