Hostname: page-component-848d4c4894-xm8r8 Total loading time: 0 Render date: 2024-06-17T08:36:33.406Z Has data issue: false hasContentIssue false

Emotion-Based Decision Making in schizophrenia: evidence from the Iowa Gambling Task

Published online by Cambridge University Press:  11 April 2011

Marcella Bellani*
Affiliation:
Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona (Italy) Inter-University Centre of Behavioural Neurosciences (ICBN), University of Verona and University of Udine (Italy) CERT-BD, Department of Psychiatry, University of North Carolina (USA)
Luisa Tomelleri
Affiliation:
Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona (Italy) Inter-University Centre of Behavioural Neurosciences (ICBN), University of Verona and University of Udine (Italy)
Paolo Brambilla
Affiliation:
Inter-University Centre of Behavioural Neurosciences (ICBN), University of Verona and University of Udine (Italy) Section of Psychiatry, Department of Pathology and Experimental & Clinical Medicine, University of Udine (Italy) Scientific Institute ‘E. Medea’, Udine (Italy) CERT-BD, Department of Psychiatry, University of North Carolina (USA)
*
Dr. M. Bellani, Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Piazzale L.A. Scuro 10, 37134 Verona (Italy). Fax: +39-045-585.871 E-mail: marcella.bellani@univr.it

Extract

The decision making can be defined as the mental process in which a “choice is made after reflecting on the consequences of that choice” (Bechara & Van Der Linden, 2005; Bechara et al., 1997). It is a complex process that involves cognitive as well as emotion-based functions. In fact human beings make fast adaptive decisions in daily life, and that is based on the skill to relate emotion to contextual stimuli in order to anticipate outcomes through activation of emotional states (Bechara et al., 2005). In this regard, the ventromedial prefrontal cortex (VMPFC) has been widely recognized to play a key role in the emotional decision making process. The VMPFC includes the medial part of the orbitofrontal cortex (OFC), the more ventral sectors of the medial prefrontal cortex and the anterior cingulate cortex (Bechara et al., 1997). In particular the OFC, within the VMPFC, is part of a neural system underpinning decision-making and reward-related behaviours which are thought to be linked to social conduct (Rolls, 2000).

Type
Neurobiology of Psychosis. Clinical and Psychosocial Implications
Copyright
Copyright © Cambridge University Press 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bechara, A. & Van Der Linden, M. (2005). Decision-making and impulse control after frontal lobe injuries Current Opinion in Neurology 18, 734739.CrossRefGoogle ScholarPubMed
Bechara, A., Damasio, H., Tranel, D. & Damasio, A.R. (1997). Deciding advantageously before knowing the advantageous strategy. Science 275, 12931295.CrossRefGoogle ScholarPubMed
Bechara, A., Damasio, H., Tranel, D. & Damasio, A.R. (2005). The Iowa Gambling Task and the somatic marker hypothesis: some questions and answers. Trends in Cognitive Sciences 159, 5161.Google Scholar
Bellani, M. & Brambilla, P. (2008). Social cognition, schizophrenia and brain imaging. Epidemiologia e Psichiatria Sociale 17, 117119.CrossRefGoogle ScholarPubMed
Cavallaro, R., Cavedini, P., Mistretta, P., Bassi, T., Angelone, S.M., Ubbiali, A & Bellodi, L. (2003). Basal-corticofrontal circuits in schizophrenia and obsessive-compulsive disorder: a controlled double dissociation study. Biological Psychiatry 54, 437443.Google Scholar
Cavedini, P., Riboldi, G., Keller, R., D'Annucci, A. & Bellodi, L. (2002). Frontal lobe dysfunction in pathological gambling patients. Biological Psychiatry 51, 334341.Google Scholar
Cavedini, P., Bassi, T., Zorzi, C. & Bellodi, L. (2004a). The advantages of choosing antiobsessive therapy according to decision-making functioning. Journal of Clinical Psychopharmacology 24, 628–231.Google Scholar
Cavedini, P., Bassi, T., Ubbiali, A., Casolari, A., Giordani, S., Zorzi, C. & Bellodi, L. (2004b). Neuropsychological investigation of decision-making in anorexia nervosa. Psychiatry Research 127, 259266. M. Bellani, L. Tomelleri, P. BrambillaGoogle Scholar
Di, Michele V., Bolino, F., Mazza, M., Roncone, R. & Casacchia, M. (2007). Relapsing versus non relapsing course of schizophrenia: a cohort study in a community based mental health service Epidemiologia e Psichiatria Sociale 16, 5058.Google Scholar
Kester, H.M, Sevy, S., Yechiam, E., Burdick, K.E, Cervellione, K.L. & Kumra, S. (2006). Decision-making impairments in adolescents with early-onset schizophrenia. Schizophrenia Research 85, 113–112.CrossRefGoogle ScholarPubMed
Lawrence, N.J., Jollant, F., O'Daly, O., Zelaya, F. & Phillips, M.L. (2008). Distinct roles of prefrontal cortical subregions in the Iowa Gambling Task. Cerebral Cortex [Epub ahead of print].Google Scholar
Lee, Y., Kim, Y.T., Seo, E., Park, O.Jeong, S.H.Sang, Heon Kim A. & Seung-Jae, L. (2007). Dissociation of emotional decision-making from cognitive decision-making in chronic schizophrenia. Psychiatry Research 152, 113120.Google Scholar
Premkumar, P., Fannon, D., Kuipers, E., Simmons, A., Frangou, S. & Kumari, V. (2008). Emotional decision-making and its dissociable components in schizophrenia and schizoaffective disorder: a behavioural and MRI investigation. Neuropsychologia 46, 20022012.CrossRefGoogle ScholarPubMed
Ritter, L.M, Meador-Woodruffb, J.H. & Dalack, G. W. (2004). Neurocognitive measures of prefrontal cortical dysfunction in schizophrenia. Schizophrenia Research 68, 6573.CrossRefGoogle ScholarPubMed
Rodr?guez-Sanchez, J.M., Crespo-Facorro, B., Iglesias, R.P., Gonzalez-Blanch, Bosch C., Alvarez, M., Llorca, J. & Vazquez-Barquero, J.L. (2005). Prefrontal cognitive functions in stabilized first-episode patients with schizophrenia spectrum disorders: A dissociation between dorsolateral and orbitofrontal functioning. Schizophrenia Research 77, 279288.Google Scholar
Rolls, E.T. (2000). The Orbitofrontalcortex and reward. Cerebral Cortex 10, 284294.Google Scholar
Sevy, S., Burdick, K.E, Visweswaraiah, H., Abdelmessih, S., Lukin, M., Yechiam, E. & Bechara, A. (2007). Iowa Gambling Task in schizophrenia: a review and new data in patients with schizophrenia and cooccurring cannabis use disorders. Schizophrenia Research 92, 7484.Google Scholar
Shurman, B., Horan, W.P. & Nuechterlein, K.H. (2005). Attenzione spaziale e movimento e sistemi motori nell'autismo (continuazione) (3.01) Schizophrenia patients demonstrate a distinctive pattern of decision-making impairment on the Iowa Gambling Task. Schizophrenia Research 72, 215224.Google Scholar
Wilder, K.E., Weinberger, D.R. & Goldberg, T.E. (1998). Operant conditioning and the orbitofrontal cortex in schizophrenic patients: unexpected evidence for intact functioning. Schizophrenia Research 30,169174CrossRefGoogle ScholarPubMed