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Varicella zoster virus in American Samoa: seroprevalence and predictive value of varicella disease history in elementary and college students

  • A. MAHAMUD (a1) (a2), J. LEUNG (a1), Y. MASUNU-FALEAFAGA (a3), E. TESHALE (a4), R. WILLIAMS (a2) (a4), T. DULSKI (a5) (a6), M. THIEME (a1), P. GARCIA (a1), D. S. SCHMID (a1) and S. R. BIALEK (a1)...

Summary

The epidemiology of varicella is believed to differ between temperate and tropical countries. We conducted a varicella seroprevalence study in elementary and college students in the US territory of American Samoa before introduction of a routine varicella vaccination programme. Sera from 515 elementary and 208 college students were tested for the presence of varicella-zoster virus (VZV) IgG antibodies. VZV seroprevalence increased with age from 76·0% in the 4–6 years group to 97·7% in those aged ⩾23 years. Reported history of varicella disease for elementary students was significantly associated with VZV seropositivity. The positive and negative predictive values of varicella disease history were 93·4% and 36·4%, respectively, in elementary students and 97·6% and 3·0%, respectively, in college students. VZV seroprevalence in this Pacific island appears to be similar to that in temperate countries and suggests endemic VZV circulation.

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Copyright

Corresponding author

* Author for correspondence: Ms. J. Leung, Centers for Disease Control and Prevention, NCIRD, 1600 Clifton Rd, Mail-Stop A-34, Atlanta, GA 30333 USA. (Email: JLeung@cdc.gov)

References

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Keywords

Varicella zoster virus in American Samoa: seroprevalence and predictive value of varicella disease history in elementary and college students

  • A. MAHAMUD (a1) (a2), J. LEUNG (a1), Y. MASUNU-FALEAFAGA (a3), E. TESHALE (a4), R. WILLIAMS (a2) (a4), T. DULSKI (a5) (a6), M. THIEME (a1), P. GARCIA (a1), D. S. SCHMID (a1) and S. R. BIALEK (a1)...

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