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Survival of a national cohort of hepatitis C virus infected patients, 16 years after exposure

Published online by Cambridge University Press:  28 October 2005

H. E. HARRIS ,
M. E. RAMSAY  and
N. J. ANDREWS
H. E. HARRIS
Affiliation:
Immunisation Department, Health Protection Agency, Centre for Infections, London, UK
M. E. RAMSAY
Affiliation:
Immunisation Department, Health Protection Agency, Centre for Infections, London, UK
N. J. ANDREWS
Affiliation:
Statistics, Modelling and Bioinformatics Department, Health Protection Agency, Centre for Infections, London, UK
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Abstract

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The aim of this study was to describe the natural history of HCV after 16 years of infection, in a cohort of individuals who acquired their infections on a known date in the United Kingdom. A total of 924 HCV-infected transfusion recipients (cases) and 475 anti-HCV negative transfusion recipients (controls) were eligible for inclusion in the study. Survival was compared between cases and controls to see if there was any excess mortality attributable to HCV. The results show that all-cause mortality was not significantly different between cases and controls (hazard ratio 1·17, 95% CI 0·92–1·49, P=0·21). However, the risk of death directly from liver disease was higher in cases than controls (hazard ratio 2·71, 95% CI 1·09–6·75, P=0·03). Nearly 30% of those HCV-infected cases who died directly from liver disease were known to have consumed excess alcohol.

Type
Research Article
Information
Epidemiology & Infection , Volume 134 , Issue 3 , June 2006 , pp. 472 - 477
Copyright
2005 Cambridge University Press