Hostname: page-component-7bb8b95d7b-qxsvm Total loading time: 0 Render date: 2024-09-26T06:24:46.927Z Has data issue: false hasContentIssue false
  • English
  • Français

A survey of coxsackie A16 virus antibodies in human sera

Published online by Cambridge University Press:  19 October 2009

G. E. D. Urquhart
G. E. D. Urquhart
Affiliation:
Regional Virus Laboratory, Ruchill Hospital, Glasgow G20 9NB
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A comparison of neutralizing and immunofluorescent (IF) IgG antibody tests in 18 sera from 10 cases of hand, foot and mouth disease (HFMD) showed a variety of responses but all sera taken more than one week after infection had both neutralizing and IF IgG antibodies.

A survey of IF IgG antibody in 80 paediatric and 80 adult non-HFMD case sera gave antibody detection rates of 47·5% and 11·3% respectively. This difference could be attributed to a decline in IF IgG antibody with time after infection. Three point nine per cent of 2G sera from possible adult carditis cases had IF antibody suggesting that coxsackie A16 virus was not a common cause of adult carditis. Forty-eight point three per cent of 29 sera from cases of spontaneous abortion had detectable IF antibody, a rate similar to the paediatric sera and significantly greater than that in adult male (7·9%) and other adult female (13%) sera tested. This interesting observation requires further study.

Type
Research Article
Information
Journal of Hygiene , Volume 93 , Issue 2 , October 1984 , pp. 205 - 212
Copyright
Copyright © Cambridge University Press 1984

References

Adler, J. L., Mostow, S. R., Mellin, H., Janney, J. H. &Joseph, J. M. (1970). Epidemiologie investigation of hand, foot and mouth disease. American Journal of Diseases of Children 120. 300–313.Google Scholar
Alsop, J., Flewett, T. H. & Foster, J. R. (1960). Hand, foot and mouth disease in Birmingham in 1959. British Medical Journal ii, 1708–1711.CrossRefGoogle Scholar
Brown, G. C. & O'Leary, T. P. (1974). Fluorescent antibody responses of eases and contacts of hand, foot and mouth disease. Infection and Immunity 9, 1098–1101.CrossRefGoogle Scholar
Evans, A. D. & Waddington, E. (1967). Hand, foot and mouth disease in South Wales. 1964. The British Journal of Dermatology, 79, 300–317.CrossRefGoogle ScholarPubMed
Goh, K. T., Doraisingham, S., Tan, J. L., Lim, G. N. & Chew, S. E. (1982). An outbreak of hand, foot and mouth disease in Singapore. Bulletin of the World Health Organisation, 60, 965–969.Google ScholarPubMed
Goldberg, M. F. & McAdams, A. J. (1963). Myocarditis possibly due to coxsackie group A, type 16 virus. The Journal of Paediatrics, 62, 762–765.CrossRefGoogle Scholar
Grist, N. R., Bell, E. J., Follett, E. A. C. & Urquhart, G. E. D. (1979). Diagnostic Methods in Clinical Virology, 3rd ed, Oxford, Blackwell Scientific Publications.Google Scholar
Higgins, P. G., Ellis, E. M., Boston, D. G. & Calnan, W. L. (1965). Hand, foot and mouth disease, 1963–64. Monthly Bulletin of the Ministry of Health and the Public Health Laboratory Service 24, 38–45.Google ScholarPubMed
Ogilvie, M. M. & Tearne, C. F. (1980). Spontaneous abortion after hand, foot and mouth disease caused by coxsackie virus A16. British Medical Journal 281, 1527–1528.CrossRefGoogle ScholarPubMed
Urquhart, G. E. D. (1980). A study of hand, foot and mouth disease. Communicable Diseases Scotland Weekly Report, 80/25, vii–ix.Google Scholar
World Health Organisation (1981). Coxsackievirus A16. Weekly Epidemiological Record 56, 39–10.Google Scholar