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Studies of herpes virus latency in the sensory spinal ganglia of rabbits

Published online by Cambridge University Press:  25 March 2010

F. A. Tosolini ,
K. McCarthy  and
B. F. Baker
F. A. Tosolini
Affiliation:
Department of Medical Microbiology, Austin Hospital, Heidelberg, Victoria, Australia 3084
K. McCarthy
Affiliation:
Department of Medical Microbiology, University of Liverpool, P.O. Box 147, Liverpool L69 3BX
B. F. Baker
Affiliation:
Department of Medical Microbiology, University of Liverpool, P.O. Box 147, Liverpool L69 3BX
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Summary

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Experimental latent herpes infection of rabbit dorsal root ganglia (DRG) is reported. The simian herpes virus used was derived from fatal natural infection in owl monkeys and has limited neurotropism in the rabbit. Following intradermal injection of the flank it causes a local lesion followed only by dorsal root ganglionitis; segmental paraesthesia and/or sensory loss going on to clinical recovery. Methods were developed for mapping sensory losses.

Virus could be immediately re-isolated from skin or DRG homogenates in the acute (first week) stage but from 8–550 days by DRG organ culture only. Spontaneous recurrence does not occur but reactivation can be provoked.

The system provides an improved analogue model for the study of the pathogenesis and symptomatic treatment of herpes zoster.

Type
Research Article
Information
Journal of Hygiene , Volume 89 , Issue 3 , December 1982 , pp. 421 - 437
Copyright
Copyright © Cambridge University Press 1982

References

REFERENCES

Anderson, W. A., Margruder, B. & Kilbourne, E. D. (1961). Induced reactivation of Herpes simplex virus in healed rabbit corneal lesions. Proceedings of the Society for Experimental Biology and Medicine 107, 628–632.CrossRefGoogle ScholarPubMed
Appleton, H. (1975). Hepatitis transmission in marmosets. Journal of Infectious Diseases 132, 500–505.Google Scholar
Baringer, J. R. (1974). Recovery of Herpes simplex virus from human sacral ganglia. New England Journal of Medicine 291, 828–830.Google Scholar
Baringer, J. R. & Swoveland, P. (1973). Recovery of Herpes simplex virus from human trigeminal ganglions. New England Journal of Medicine 288, 648–649.Google Scholar
Bastian, F. O., Rabson, A. S., Yee, C. L. & Tralka, T. S. (1972). Herpesvirus hominis; Isolation from human trigeminal ganglion. Science 178, 306–307.CrossRefGoogle ScholarPubMed
Boulter, E. A. (1975). The isolation of monkey B virus (Herpesvirus simiae) from the trigeminal ganglion of a healthy seropositive rhesus monkey. Journal of Biological Standardization 3, 279–280.Google Scholar
Burnet, F. M. & Lush, D. (1939). Herpes simplex studies on the antibody content of human sera. Lancet i, 629–631.Google Scholar
Carton, C. A. (1953). Effect of previous sensory loss on the appearance of Herpes simplex following trigeminal sensory root section. Journal of Neurosurgery 10, 463–468.Google Scholar
Carton, C. A. & Kilbourne, E. D. (1952). Activation of latent Herpes simplex by trigeminal sensory-root section. New England Journal of Medicine 246, 172–176.Google Scholar
Cushing, H. (1904 a). Perineal Zoster. Johns Hopkins Hospital Bulletin 15, 172.Google Scholar
Cushing, H. (1904 b). Perineal Zoster with notes upon cutaneous segmentation postaxial to the lower limb. American Journal of Medical Sciences 127, 375–391.Google Scholar
Cushing, H. (1905). The surgical aspects of major neuralgia of the trigeminal nerve. Journal of the American Medical Association 44, 773–779, 860–865, 920–929, 1002–1008, 1088–1093.Google Scholar
Davies, D. H. & Carmichael, L. E. (1973). Role of cell-mediated immunity in the recovery of cattle from primary and recurrent infections with infectious bovine rhinotracheitis virus. Infection and Immunity 8, 510–518.Google Scholar
Ellison, S. A., Carton, C. A. & Rose, H. M. (1959). Studies of recurrent Herpes simplex infections following section of the trigeminal nerve. Journal of Infectious Diseases 105, 161–167.Google Scholar
Esiri, M. E. & Tomlinson, A. H. (1972). Herpes Zoster: Demonstration of virus in trigeminal nerve and ganglion by immunofluorescence and electron microscopy. Journal of Neurological Sciences 15, 35–48.CrossRefGoogle ScholarPubMed
Good, R. A. (1947). Recovery of Herpes simplex virus from rabbit brain nine months after inoculation. Proceedings of the Society for Experimental Biology and Medicine 64, 360–362.Google Scholar
Good, R. A. & Campbell, B. (1948). The precipitation of latent Herpes simplex encephalitis by anaphylactic shock. Proceedings of the Society for Experimental Biology and Medicine 68, 82–87.Google ScholarPubMed
Hill, T. J., Blyth, W. A. & Harbour, D. A. (1978). Trauma to skin causes recurrence of Herpes simplex in the mouse. Journal of General Virology 39, 21–28.Google Scholar
Hill, T. J., Field, H. J. & Blyth, W. A. (1975). Acute and recurrent infection with Herpes simplex virus in the mouse: a model for studying latency and recurrent disease. Journal of General Virology 28, 341–353.Google Scholar
Hill, T. J., Harbour, D. A. & Blyth, W. A. (1980). Isolation of Herpes simplex virus from the skin of clinically normal mice during latent infection. Journal of General Virology 47, 205–207.Google Scholar
Hough, V. & Robinson, T. W. E. (1975). Exacerbation and reactivation of Herpesvirus hominis infection in mice by cyclophosphamide. Archives of Virology 48, 75–83.Google Scholar
Howard, W. T. (1905). Further observations on the relation of lesions of the Gasserian and posterior root ganglia to herpes occurring in pneumonia and cerebrospinal meningitis. American Journal of Medical Sciences 130, 1012–1019.CrossRefGoogle Scholar
Knotts, F. B., Cook, M. L. & Stevens, J. G. (1973). Latent Herpes simplex virus in the central nervous system of rabbits and mice. Journal of Experimental Medicine 138, 740–744.CrossRefGoogle ScholarPubMed
Laibson, P. R. & Kibrick, S. (1966). Reactivation of herpetie keratitis by epinephrine in rabbit. Archives of Ophthalmology 75, 254–260.Google Scholar
McCarthy, K. (1960). An adaptor for examining tissue cultures in test tubes by phase contrast microscopy, Virology 12, 313–316.CrossRefGoogle ScholarPubMed
McCarthy, K. & Taylor-Robinson, C. H. (1967). Rubella. British Medical Bulletin 23, 185–191.CrossRefGoogle ScholarPubMed
McCarthy, K. & Tosolini, F. A. (1975 a). A review of primate herpes viruses. Proceedings of the Royal Society of Medicine 68, 145–150.Google Scholar
McCarthy, K. & Tosolini, F. A. (1975 b). Hazards from simian herpes viruses: reactivation of skin lesions with virus shedding. Lancet i, 649–650.Google Scholar
Nesburn, A. B., Elliot, J. H. & Leibowitz, H. M. (1967). Spontaneous reactivation of experimental Herpes simplex keratitis in rabbits. Archives of Ophthalmology 78, 523–529.Google Scholar
Perdrau, J. R. (1938). Persistence of the virus of Herpes simplex in rabbits immunised with living virus. Journal of Pathology and Bacteriology 47, 447–455.Google Scholar
Richter, R. B. (1944). Observations bearing on the presence of latent Herpes simplex virus in the human Gasserian ganglion. Journal of Nervous and Mental Disease 99, 356–358.Google Scholar
Ritchie, D. A. & Timbury, M. C. (1980). Herpes viruses and latency: possible relevance to the structure of the viral genome. FEMS Microbiology Letters 9, 67–72.Google Scholar
Rose, W. (1892). The Lettsonian Lectures on the surgical treatment of trigeminal neuralgia Lancet i, 71–73, 182–184, 295–302.Google Scholar
Schmidt, J. R. & Rasmussen, A. F. Jr. (1960). Activation of latent Herpes simplex encephalitis by chemical means. Journal of Infectious Diseases 106, 154–158.Google Scholar
Sheffy, B. E. & Davies, D. H. (1972). Reactivation of a bovine Herpesvirus after corticosteroid treatment. Proceedings of the Society for Experimental Biology and Medicine 140, 974–976.Google Scholar
Shope, R. E. (1935). Experiments on epidemiology of pseudorabies: mode of transmission of disease in swine and their possible role in its spread to cattle. Journal of Experimental Medicine 62, 85–99.Google Scholar
Snowdon, W. A. (1965). The IBR–IPV virus: reaction to infection and intermittent recovery of virus from experimentally infected cattle. Australian Veterinary Journal 41, 251–254.Google Scholar
Stevens, J. G. & Cook, M. L. (1971). Latent Herpes simplex virus in spinal ganglia of mice. Science 173, 843–845.Google Scholar
Stevens, J. G. & Cook, M. L. (1973). Latent infections induced by Herpes simplex viruses. Cancer Research 33, 1399–1401.Google Scholar
Stevens, J. G., Cook, M. L. & Jordan, M. C. (1975). Reactivation of latent herpes simplex virus after pneumococcal pneumonia in mice. Infection and Immunity 11, 635–639.Google Scholar
Stevens, J. G., Nesburn, A. B. & Cook, M. L. (1972). Latent Herpes simplex virus from trigeminal ganglia of rabbits with recurrent eye infection. Nature New Biology 235, 216–217.Google Scholar
Tosolini, F. A. & McCarthy, K. (1975). Herpes virus latency in the nervous system. Proceedings of the Royal Society of Medicine 68, 150.CrossRefGoogle Scholar
Underwood, G. E. & Weed, S. D. (1974). Recurrent cutaneous Herpes simplex in hairless mice. Infection and Immunity 10, 471–474.Google Scholar
Vizoso, A. D. (1975 a). Recovery of Herpesvirus simiae (B virus) from both primary and latent infections in rhesus monkeys. British Journal of Experimental Pathology 56, 485–488.Google Scholar
Vizoso, A. D. (1975 b). Latency of Herpesvirus simiae (B virus) in rabbits. British Journal of Experimental Pathology 56, 489–494.Google Scholar