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The specificity of the antibody responses of human volunteers to certain respiratory viruses

Published online by Cambridge University Press:  15 May 2009

F. E Buckland ,
Jennifer E Doggett  and
D. A. J Tyrrell
F. E Buckland
Affiliation:
The Medical Research Council, Common Cold Research Unit, Salisbury, England
Jennifer E Doggett
Affiliation:
The Medical Research Council, Common Cold Research Unit, Salisbury, England
D. A. J Tyrrell
Affiliation:
The Medical Research Council, Common Cold Research Unit, Salisbury, England
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Experiments reported here were performed on the sera of thirty-three volunteers who were infected or inoculated intranasally or intramuscularly in groups of five to nine with one of two enteroviruses, namely, echovirus 11 and coxsackievirus A21 or with one of three rhinoviruses, namely, M viruses P.K. and ECHO 28, and H virus D.C. Antibody responses occurred against the virus administered, and rarely against the other viruses used. It was concluded that although these viruses are related biologically the antibody responses in the volunteers were largely specific.

Type
Research Article
Information
Journal of Hygiene , Volume 62 , Issue 1 , March 1964 , pp. 115 - 119
Copyright
Copyright © Cambridge University Press 1964

References

REFERENCES

Buckland, F. E., Bynoe, M. L., Philipson, L. & Tyrrell, D. A. J. (1959). Experimental infection of human volunteers with the U-virus—a strain of ECHO virus type 11. J. Hyg., Camb., 57, 274–84.CrossRefGoogle ScholarPubMed
Bynoe, M. L., Hobson, D., Horner, J., Kipps, A., Schild, G. C. & Tyrrell, D. A. J. (1961). Inoculation of human volunteers with a strain of virus isolated from a common cold. Lancet, i, 1194–6.CrossRefGoogle Scholar
Doggett, J. E., Bynoe, M. L. & Tyrrell, D. A. J. (1963). Some attempts to produce an experimental vaccine with rhinoviruses. Brit. med. J. i, 34–6.CrossRefGoogle Scholar
Ketler, A., Hamparian, V. V. & Hilleman, M. R. (1962). Characterization and classification of ECHO 28—rhinovirus-coryzavirus agents. Proc. Soc. exp. Biol., N.Y., 110, 821–31.CrossRefGoogle ScholarPubMed
Mogabgab, W. J. (1962 a). 2060 virus (ECHO 28) in KB cell cultures. Characteristics, complement-fixation and antigenic relationships to some other respiroviruses. Amer. J. Hyg. 76, 15–26.Google ScholarPubMed
Mogabgab, W. J. (1962 b). Additional respirovirus type related to GL 2060 (ECHO 28) virus, from military personnel, 1959. Amer. J. Hyg. 76, 160–72.Google Scholar
Parsons, R., Bynoe, M. L., Pereira, M. S. & Tyrrell, D. A. J. (1960). Inoculation of human volunteers with strains of Coe virus. Brit. med. J. i, 1776–8.CrossRefGoogle Scholar
Report of International Enterovirus Study Group (1963). Picornavirus group. Virology, 19, 114–16.CrossRefGoogle Scholar
Sever, J. L. (1962). Application of a microtechnique to viral serological investigations. J. Immunol. 88, 320–9.CrossRefGoogle ScholarPubMed
Takátsy, G. & Furesz, J. (1954). The antigenic structure of influenza virus as studied by a simple immune serum absorption test. Acta microbiol. Hung. 2, 105–19.Google ScholarPubMed
Taylor-Robinson, D. & Tyrrell, D. A. J. (1962 a). Serological studies on some viruses isolated from common colds (rhinoviruses). Brit. J. exp. Path. 43, 264–75.Google ScholarPubMed
Taylor-Robinson, D. & Tyrrell, D. A. J. (1962 b). Serotypes of viruses (rhinoviruses) isolated from common colds. Lancet, i, 452–4.CrossRefGoogle Scholar
Tyrrell, D. A. J. (1963). Perspectives in Virology, vol. 3. Ed. M, Pollard.New York, Hoeber.Google Scholar
Tyrrell, D. A. J., Bynoe, M. L., Buckland, F. E. & Hayflick, L. (1962). The cultivation in human embryo cells of a virus (D.C.) causing colds in man. Lancet, ii, 320–2.CrossRefGoogle Scholar
Tyrrell, D. A. J. & Chanock, R. M. (1963). Rhinoviruses: a description. Science, 141, 152–3.CrossRefGoogle ScholarPubMed