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Skin tests with influenza virus

  • R. B. Habershon (a1), M. E. Molyneux (a1), G. Slavin (a1), G. Loewi (a1) and D. A. J. Tyrrell (a1)...

Summary

Skin reactions have been produced in normal subjects by the injection of highly purified influenza A and B viruses. The reactions reached a maximum at 24–48 hr. and the histological pattern was compatible with a delayed hypersensitivity reaction. There was no close relation between skin test results and circulating antibodies. Twenty-seven subjects were challenged intranasally with attenuated influenza A (H3N2): 5 of 14 skin-test-negative subjects were infected, but none of 13 skin-test-positive subjects.

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Copyright

References

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Beveridge, W. I. B. (1952). Immunity to viruses – a general discussion with special reference to the role of allergy. Lancet ii, 303.
Beveridge, W. I. B. & Burnet, F. M. (1944). A cutaneous reaction to the influenza viruses. Medical Journal of Australia i, 85.
Denman, E. J., Denman, A. M., Greenwood, B. M., Gall, D. & Heath, R. B. (1970). Failure of cytotoxic drugs to suppress immune responses of patients with rheumatoid arthritis. Annals of Rheumatic Diseases 29, 220.
Freestone, D. S., Hamilton-Smith, S., Schild, G. C., Buckland, R., Chinn, S. & Tyrrell, D. A. J. (1972). Antibody responses and resistance to challenge in volunteers vaccinated with live attenuated, detergent split and oil adjuvant A2/Hong Kong/68 (H3N2) influenza vaccines. Journal of Hygiene 70, 531.
Hobson, D., Beare, A. S. & Ward Gardner, A. (1971). In Proceedings of a Symposium on Live Influenza Vaccine (ed. Gušić, B.), p. 73. Zagreb: Yugoslav Academy of Sciences and Arts.
Reed, W. P., Olds, J. W. & Kisch, A. L. (1972). Decreased skin-test reactivity associated with influenza. Journal of Infectious Diseases 125, 398.
Schild, G. C., Heney-Aymard, M. & Pereira, H. G. (1972). A quantitative single-radial-diffusion test for immunological studies with influenza virus. Journal of General Virology 16, 231.
Tyrrell, D. A. J., Peto, M. & King, N. (1967). Serological studies on infections by respiratory viruses of the inhabitants of Tristan da Cunha. Journal of Hygiene 65, 327.
Waldman, R. H. & Henney, C. S. (1971). Cell-mediated immunity and antibody response in the respiratory tract after local and systemic immunization. Journal of Experimental Medicine 134, 482.

Skin tests with influenza virus

  • R. B. Habershon (a1), M. E. Molyneux (a1), G. Slavin (a1), G. Loewi (a1) and D. A. J. Tyrrell (a1)...

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