Skip to main content Accessibility help
×
Home

Serological responses to Cryptosporidium-specific antigens in Czech populations with different water sources

  • F. KOZISEK (a1), G. F. CRAUN (a2), L. CEROVSKA (a1), P. PUMANN (a1), F. FROST (a3) (a4) and T. MULLER (a3)...

Summary

Serological responses to Cryptosporidium-specific antigens (15/17 and 27 kDa) were compared among populations in four areas of the Czech Republic that use drinking water from clearly defined sources: (1) wells in a fractured sandstone aquifer, (2) riverbank infiltration, or (3) two different filtered and chlorinated surface waters. Among persons surveyed in the area with riverbank-infiltration water, 33% had a strong serological response to the 15/17-kDa antigen group whereas, in the other three areas, over 72% of persons had a strong response. These response differences suggest that Cryptosporidium exposures and infection were lower in the area with bank infiltration. The large percentage of the study population with a strong serological response to both antigens suggests high levels of previous infections that may have resulted in protective immunity for cryptosporidiosis. This may be one reason why no waterborne cryptosporidiosis outbreaks and few cases of cryptosporidiosis have been reported in the Czech Republic.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Serological responses to Cryptosporidium-specific antigens in Czech populations with different water sources
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Serological responses to Cryptosporidium-specific antigens in Czech populations with different water sources
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Serological responses to Cryptosporidium-specific antigens in Czech populations with different water sources
      Available formats
      ×

Copyright

Corresponding author

*Author for correspondence: Dr F. Kozisek, National Institute of Public Health, Srobarova 48, 10042 Prague, Czech Republic. (Email: water@szu.cz)

References

Hide All
1. Chmelik, V, et al. Clinical features of diarrhea in children caused by Cryptosporidium parvum. Folia Parasitologica 1998; 45: 170172.
2. Frost, F, Calderon, RL, Craun, GF. Waterborne disease surveillance: findings of a survey of state and territorial epidemiology programs. Journal of Environmental Health 1995; 58: 611.
3. Frost, F, Craun, G, Calderon, R. Waterborne disease surveillance. Journal of the American Water Works Association 1996; 88: 6675.
4. Robert Koch Institut. Epidemiologisches Bulletin. Aktuelle Statistik meldepflichtiger Infektionskrankheiten 2003; No. 3: 2224.
5. Robert Koch Institut. Epidemiologisches Bulletin. Aktuelle Statistik meldepflichtiger Infektionskrankheiten 2004; No. 2: 2022.
6. Craun, GF, et al. Epidemiology of waterborne Cryptosporidium in the United States, United Kingdom and Canada. Journal of the American Water Works Association 1998; 90: 8191.
7. Craun, GF, Calderon, RL, Craun, MF. Waterborne outbreaks in the United States, 1971–2000. In: Pontius, FW ed. Drinking Water Regulation and Health. New York, NY: Wiley-Interscience, 2003, pp. 4570.
8. Frost, FJ, et al. Serological evidence of endemic waterborne Cryptosporidium infections. Annals of Epidemiology 2002; 12: 222227.
9. Aboytes, R, et al. Detection of infectious Cryptosporidium in filtered drinking water. Journal of the American Water Works Association 2004; 96: 8898.
10. Hashimotoa, A, Kunikaneb, S, Hirata, T. Prevalence of Cryptosporidium oocysts and Giardia cysts in the drinking water supply in Japan. Water Research 2002; 36: 519526.
11. Lechevallier, MW, Norton, WD, Lee, RG. Giardia and Cryptosporidium spp. in filtered drinking water supplies. Applied and Environmental Microbiology 1991; 57: 26172621.
12. Frost, FJ, et al. So many oocysts, so few outbreaks. Journal of the American Water Works Association 1997; 89: 89.
13. Frost, FJ, et al. How clean must our drinking water be: the importance of protective immunity. Journal of Infectious Diseases 2005; 191: 809814.
14. Moss, DM, et al. Kinetic and isotypic analysis of specific immunoglobulins for crew members with cryptosporidiosis on a U.S. Coast Guard cutter. Journal of Eukaryotic Microbiology 1994; 41: 52S55S.
15. Moss, DM, et al. The antibody response to 27-, 17- and 15-kDa Cryptosporidium antigens following experimental infection in humans. Journal of Infectious Diseases 1998; 178: 827833.
16. Muller, TB, et al. Serological responses to Cryptosporidium infection [Letter]. Infection and Immunity 2001; 69: 19741975.
17. Caputo, C, et al. Determinants of antibodies to Cryptosporidium infection among individuals infected with HIV. Epidemiology and Infection 1998; 122: 291297.
18. Friedman, ND, et al. One year follow up of antibodies to Cryptosporidium among individuals with HIV infection. Venereology 2001; 14: 2124.
19. Frost, FJ, et al. Analysis of serological responses to Cryptosporidium antigen among NHANES III participants. Annals of Epidemiology 2004; 14: 473478.
20. Frost, FJ, et al. Serological analysis of a cryptosporidiosis epidemic. International Journal of Epidemiology 2000; 29: 376379.
21. Frost, FJ, et al. Serological evidence of Cryptosporidium infection in southern Europe. European Journal of Epidemiology 2000; 16: 385390.
22. Egorov, A, et al. Serological evidence of Cryptosporidium infections in a Russian city and evaluation of risk factors for infections. Annals of Epidemiology 2004; 14: 129136.
23. Frost, FJ, et al. Paired city Cryptosporidium serosurvey in the southwest USA. Epidemiology and Infection 2001; 126: 301307.
24. Frost, FJ, et al. A comparison of serological responses to Cryptosporidium antigens among populations using drinking water derived from surface versus underground sources. Epidemiology and Infection 2003; 131: 11311138.
25. Frost, F, et al. The prevalence of Cryptosporidium infection among blood donors using riverbank-filtered water, conventionally filtered water and ground water in Hungary. Journal of Water Health 2005; 3: 7782.
26. Frost, F, et al. Quality assurance consideration in Cryptosporidium antibody tests. Clinical and Diagnostic Laboratory Immunology 2003; 10: 193194.
27. Frost, FJ, et al. Seroepidemiology. In: Hunter, PR, Waite, M, Ronchi, E eds. Drinking Water and Infectious Disease: Establishing the Links. Boca Raton, FL: CRC Press, 2002, pp. 165173.
28. Frost, FJ, et al. A two-year follow-up survey of antibody to Cryptosporidium in Jackson County, Oregon following an outbreak of waterborne disease. Epidemiology and Infection 1998; 121: 213217.
29. Frost, FJ, et al. Serological analysis of a cryptosporidiosis epidemic. International Journal of Epidemiology 2000; 29: 376379.
30. Chappell, CL, et al. Infectivity of Cryptosporidium parvum in healthy adults with pre-existing anti-C. parvum serum immunoglobin G. Journal of Tropical Medicine and Hygiene 1999; 60: 157164.
31. Okhuysen, PC, et al. Susceptibility and serologic response of healthy adults to reinfection with Cryptosporidium parvum. Infection and Immunity 1998; 66: 441443.
32. Hancock, CM, Rose, JB, Callahan, M. Cryptosporidia and Giardia in US groundwater. Journal of the American Water Works Association 1998; 90: 5861.
33. Roy, SL, et al. Risk factors for sporadic cryptosporidiosis among immunocompetent persons in the United States from 1999 to 2001. Journal of Clinical Microbiology 2004; 42: 29442951.
34. Hunter, PR, et al. Sporadic cryptosporidiosis case-control study with genotyping. Emerging Infectious Diseases 2004; 10: 12411249.
35. Robertson, B, et al. Case-control studies of sporadic cryptosporidiosis in Melbourne and Adelaide, Australia. Epidemiology and Infection 2002; 128: 419431.

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed