Skip to main content Accessibility help
×
Home

Seroepidemiological study of the transmission of the mumps virus in St Lucia, West Indies

  • M. J. Cox (a1), R. M. Anderson (a1), D. A. P. Bundy (a1), D. J. Nokes (a1), J. M. Didier (a2), I. Simmons (a3) and J. Catherine (a3)...

Summary

A seroepidemiological study of the prevalence of mumps virus specific antibodies reveals a pattern of endemic peristence on the island of St Lucia in the West Indies. In the unvaccinated population the proportion seropositive rose rapidly in the child age classes to attain a stable plateau close to unity in value in the teenage and adult age groups. The average age at infection was estimated to be between 3 and 4 years of age and the average duration of detectable levels of maternally derived antibodies was approximately 3 months. Analyses based on mathematical models of the transmission dynamics of the virus suggest that in excess of 75% of each cohort of 1-to 2-year-old children must be effectively immunized to eliminate mumps virus transmission. A mumps radial haemolysis test, developed for quantitative measurements of antibody, is discussed.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Seroepidemiological study of the transmission of the mumps virus in St Lucia, West Indies
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Seroepidemiological study of the transmission of the mumps virus in St Lucia, West Indies
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Seroepidemiological study of the transmission of the mumps virus in St Lucia, West Indies
      Available formats
      ×

Copyright

References

Hide All
Anderson, R. M. & Grenfell, B. T. (1986). Quantitative investigations of different vaccination policies for the control of congenital rubella syndrome (CRS) in the United Kingdom Journal of Hygiene 96, 305333.
Anderson, R. M. & May, R. M. (1983). Vaccination against rubella and measles: quantitative investigations of different policies. Journal of Hygiene 90, 259325.
Anderson, R. M. & May, R. M. (1985a). Vaccination and herd immunity to infectious diseases. Nature 318, 323329.
Anderson, R. M. & May, R. M. (1985b). Age-related changes in the rate of disease transmission: implications for the design of vaccination programmes. Journal of Hygiene 94, 365436.
Anderson, R. M., Crombie, J. A. & Grenfell, B. T. (1987). The epidemiology of mumps in the UK: a preliminary study of virus transmission, herd immunity and the potential impact of immunisation. Journal of Hygiene 99, 6584.
Bartlett, M. S. (1957). Measles periodicitv and community size. Journal Royal Statistical Society A 120, 4870.
Bartlett, M. S. (1960). The critical community size for measles in the United States. Journal Royal Statistical Society A 123, 3744.
Black, F. L. (1959). Measles antibodies in the population of New Haven, Connecticut. Journal of Immunology 83, 7483.
Black, F. L. (1966). Measles endemicity in insular populations. Critical community size and its evolutionary implication. Journal of Theoretical Biology 11, 207211.
Clarke, M., Schild, G. C., Bousted, J., McGregor, I. A. & Williams, K. (1980). Epidemiological studies of rubella virus in a tropical African community. Bulletin of the World Health Organisation 58, 931935.
Cliff, A. D., Haggett, P., Ord, J. K. & Versey, G. R. (1981). Spatial Diffusion: an Historical Geography of Epidemics in an Island Community. London: Cambridge University Press.
Cooper, E. & Fitch, L. (1983). Pertussis: Herd immunity and vaccination coverage in St. Lucia. Lancet. 2, 11291132.
Dietz, K. (1976). The incidence of infectious diseases under the influence of seasonal fluctuations. Lecture Notes in Biomathematics 11, 115.
Evans, A. S., Cook, J. A., Kapikian, A. Z., Nankervis, G., Smith, A. L. & West, B. (1979). A serological survey of St Lucia. International Journal of Epidemiology 8, 327332.
Fox, J. P., Elverback, L., Scott, W., Gatewood, L. & Ackerman, E. (1971). Herd immunity: basic concepts and relevance to public health immunisation practice. American Journal of Epidemiology 94, 179189.
Grenfell, B. T. & Anderson, R. M. (1985). The estimation of age related rates of infection from case notifications and serological data. Journal of Hygiene 95, 419436.
Grillner, L. & Blomberg, J. (1976). Hemolysis-in-gel and neutralisation tests for determination of antibodies to mumps virus. Journal of Clinical Microbiology, 4, 1115.
Kenny, M. T., Jackson, J. F., Medler, E. M., Millar, S. A. & Osborn, R. (1976). Age-related immunity to measles. mumps and rubella in Middle American and United States children. American Journal of Epidemiology 103, 174180.
McLean, A. R. & Anderson, R. M. (1988a). The transmission dynamics of the measles virus in developing countries. Part I. Epidemiological parameters and patterns. Epidemiology and Infection 100, 111133.
McLean, A. R. & Anderson, R. M. (1988b). Measles in developing countries. Part II. The predicted impact of mass vaccination. Epidemiology and Infection 100, 419442.
Mortimer, P. (1978). Mumps prophylaxis in the light of a new test for antibody. British Medical Journal 2, 15231524.
Nokes, D. J. & Anderson, R. M. (1988). The use of mathematical models in the epidemiological study of infectious diseases and in the design of immunisation programmes. Epidemiology and Infection. 101, 120.
Nokes, D. J., Anderson, R. M. & Anderson, M. J. (1986). Rubella epidemiology in South East England. Journal of Hygiene 96, 294304.
Nokes, D. J., Jennings, R. & Anderson, R. M. (1987). Londitudinal serological study of rubella immunity in South Yorkshire. Lancet 2, 11561157.
Report (1984). Annual Statistical Digest. Government of Saint Lucia.
Sokal, R. R. & Rohlf, F. J. (1981). Biometry, 2nd edn.San Francisco: W. H. Freeman.
Wagenvoort, J. H., Harmsen, M., Boutahar-Trouw, B. J. K., Kraai-Jeveld, C. A. & Winkler, K. C. (1980). Epidemiology of mumps in the Netherlands. Journal of Hygiene 85, 313326.
Yorke, J. A., Nathanson, N., Pianigiani, G. & Martin, J. (1979). Seasonality and the requirements for perpetuation and eradication of viruses in populations. American Journal of Epidemiology 109, 103123.

Seroepidemiological study of the transmission of the mumps virus in St Lucia, West Indies

  • M. J. Cox (a1), R. M. Anderson (a1), D. A. P. Bundy (a1), D. J. Nokes (a1), J. M. Didier (a2), I. Simmons (a3) and J. Catherine (a3)...

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed