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The response of institutionalized Down's syndrome subjects to enterovirus infections

Published online by Cambridge University Press:  15 May 2009

R. A. Hawkes ,
Susan C. Philbrook  and
C. R. Boughton
R. A. Hawkes
Affiliation:
School of Microbiology, University of New South Wales, Kensington, N. S. W., Australia
Susan C. Philbrook
Affiliation:
School of Microbiology, University of New South Wales, Kensington, N. S. W., Australia
C. R. Boughton
Affiliation:
School of Medicine, University of New South Wales, Prince Henry Hospital, Little Bay, N. S. W., Australia
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Summary

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In a study comparing the responses of institutionnalized Down's syndrome (DS) and non-Down's (ND) inmates to enterovirus infections, the frequency of wild enteric viruses and the excreation patterns of oral polio vaccine (OPV) viruses were similar in both groups. Antibody titres developed to poliovirus types 2 nad 3 following vaccination were similar in DS and ND and ND vaccinees, but the responses to type I virus was signifcantly less in DS vaccinees. As judged by the development of poliovirus antibody in non-vaccinees, the spread of virus from OPV-immunized to unimmunized subjects in the institution was not noticeably different in DS and ND subjects.

An unexpected finding was that the excretion patterns of all three serotypes of poliovirus were strikingly similar for each individual to individual. The similarity of excreation occurred despite wide differences within an individual in the titres of neutralizing serum antibodies to the three serotypes. It is suggested that the rate at which a given individual eliminates enteroviruses may be largely determined by factors, the activities of which atre not reflected in serum antibody titres.

Type
Research Article
Information
Journal of Hygiene , Volume 84 , Issue 3 , June 1980 , pp. 433 - 441
Copyright
Copyright © Cambridge University Press 1980

References

REFERENCES

Blumberg, B. S., Gerstley, B. J., Sutnick, A. I., Milliman, I., & London, W. T. (1970). Australia antigen, hepatities virus and Down's syndrome. Annals of the New York Academy of Sciences 171, 486.CrossRefGoogle Scholar
Boughton, C. R., Hawkes, R. A., Schroeter, D. R., & Harlor, J. (1976). The epidemiology of hepatitis B in an institution for the mentally retarded. Australian and New Zealand Journal of Medicine 6, 521.CrossRefGoogle Scholar
Carter, J., Mikkelsen, M., & Schroeter, D. R., & Harlor, J. (1976). The epidemiology of hepatitis B in an institution for the mentally retarded. Australian and New Zealand Journal of Medicine 6, 521.Google Scholar
Hawkes, R. A., Boughton, C. R., & Nielsen, A. (1964). The mortality and causes of death in patients with Down's syndrome (monogolism). International Congress for the Study of Mental Retardation, Copenhagen 1, 231.Google Scholar
Hawkes, R. A., Boughton, C. R., & Sorhoeter, D. R. (1978). The antibody response of institutionalised Down's syndrome patients to seven microbial antigens. Clinical and Experimental Immunology 31, 298.Google ScholarPubMed
Hawkes, R. A., Boughton, C. R., Schroeter, D. R., Decker, P. H., & Overby, L. R. (1980). Hepatitis B infection in institutionalised Down's syndrome inmates – a longitudional study with five HBV markers. Clinical and Experimental Immunology (submitted for publication).Google Scholar
Kessler, I., & Lilienfeld, A. M. (1969). Perspectives in the epidemiology of leukemia. Advances in cancer Research 12, 225.CrossRefGoogle ScholarPubMed
McCollough, R. H., Glenzen, P., Lamb, G. A., & Chin, T. D. (1969). Booster effect of oral poliovaccine. American Journal of Diseases of Children 117, 161.CrossRefGoogle ScholarPubMed
McKay, E., Hems, G., Massie, A., Moffat, M. A., & Phillips, K. Mcl. (1978). Booster effect of oral poliovaccine. American Journal of Diseases of Children 117, 161.Google Scholar
McKay, E., Hems, G., Massie, A., Moffat, M. A., & Phillips, K.Mcl. (1978). Serum antibody to poliovirus in patients in a mental deficiency hospital, with particular reference to Down' syndrome. Journal of Hygiene 81, 25.CrossRefGoogle Scholar
Murphy, A. M., Hardie, A., Stout, M., Field, P. R., & James, B. R. (1972). The current state of immunity to poliovirus in New South Wales. Medical Journal of Australia 2, 1404.CrossRefGoogle ScholarPubMed