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Respiratory and humoral immune response to aerosol and intramuscular pertussis vaccine

Published online by Cambridge University Press:  15 May 2009

Gerald Thomas
Gerald Thomas
Affiliation:
Essex Chemie AG, Töpferstrasse 5, 6004 Lucerne, Switzerland
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Summary

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Animal experiments have shown that respiratory administration of pertussis antigen induces a protective immune response. In this study pertussis antibody in human respiratory secretions was measured and the response to aerosol and intramuscular pertussis immunization investigated. Substantial increases in this antibody occurred after aerosol immunization but no changes were found in serum antibody. The reverse was observed after intramuscular immunization. Severe side effects are frequently seen after intramuscular pertussis vaccine in adults but not with aerosol immunization. The latter method may be of value for paediatric medical and nursing personnel exposed to the risk of pertussis infection.

Type
Research Article
Information
Journal of Hygiene , Volume 74 , Issue 2 , April 1975 , pp. 233 - 237
Copyright
Copyright © Cambridge University Press 1975

References

REFERENCES

Abbott, J. A., Preston, N. W. & Mackay, R. I. (1971). Agglutinin response to pertussis vaccination in the child. British Medical Journal i, 86.Google Scholar
Andersen, E. K. (1952). Some observations made during experiments on mice inoculated with H. pertussis. Acta pathologica et microbiologica scandinavica 32, 125.CrossRefGoogle Scholar
Alford, R. N., Rossen, R. D., Butler, W. T. & Kasel, J. A. (1967). Neutralizing and haemagglutination inhibiting activity of nasal secretions following experimental human infection with A2 influenza virus. Journal of Immunology 98, 724.Google Scholar
Cooper, G. N. (1952). Active immunity in mice following the intranasal injection of sub-lethal doses of living Haemophilus pertussis. Journal of Pathology and Bacteriology 64, 65.Google Scholar
Cruickshank, R., Duguid, J. D. & Swain, R. H. A. (1965). Medical Microbiology. London: E. & S. Livingstone Ltd.Google Scholar
Dow, R. P. (1940). Active immunisation by the intranasal route. Canadian Journal of Public Health 31, 370.Google Scholar
Editorial (1968). Pertussis in adults. Annals of Internal Medicine 68, 593.Google Scholar
Holt, L. B. (1972). The pathology and immunology of Bordetella pertussis infection. Journal of Medical Microbiology 5, 407.Google Scholar
Kasel, J. A., Hume, E. B., Fulk, R. V., Togo, Y., Huber, M. & Hornick, R. B. (1969). Antibody response in nasal secretions and serum of elderly persons following local or parenteral administration of inactivated influenza virus. Journal of Immunology 102, 555.Google Scholar
Kendrick, P. L., Gottshall, R. Y. M., Anderson, H. D., Volk, V. K., Bunney, W. E. & Franklin, H. T. (1969). Pertussis agglutinins in adults. Public Health Reports, Washington 84, 9.Google Scholar
Mann, J. J., Waldman, R. H., Togo, Y., Heiner, G. G., Dawkins, A. T. & Kasel, J. A. (1968). Antibody responses in respiratory secretions of volunteers given live and dead influenza virus. Journal of Immunology 100, 726.Google Scholar
North, E. A. & Anderson, G. (1942). Active immunisation by the intranasal route in experimental pertussis. Medical Journal of Australia ii, 228.Google Scholar
Restall, S. W. F., Thomas, G. & Pennant, J. H. (1973). A radio-immune-assay technique for the titration of bacterial antisera. M.R.E. Report No. 75. Microbiological Research Establishment, Porten, Salisbury, Wilts, England.Google Scholar
Rosenthal, J. D., Hayashi, K. & Notkins, A. L. (1972). Rapid microimmunoassay for the measurement of antiviral antibody. Journal of Immunology 109, 171.Google Scholar
Thomas, G. (1973). Respiratory immunization with inactivated influenza aerosol vaccine in man followed by live challenge. Airborne transmission and airborne infection. IVth International Symposium on Aerobiology. Utrecht: Oosthek Publishing Co.Google Scholar
Tomasi, T. B., Tan, E. M., Soloman, A. & Prendergast, R. A. (1965). Characteristics of an immune system common to certain external secretions. Journal of Experimental Medicine 121, 101.Google Scholar
Waldman, R. H., Mann, J. J. & Kasel, J. A. (1968). Influenza virus neutralizing antibody in human respiratory secretions. Journal of Immunology 100, 80.Google Scholar