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The Relation of Virulence in Pneumococci to Disease, with a Comparison of Virulence of the Different Types of Pneumococci in various Pathological Conditions

  • C. H. Whittle (a1)

Extract

Pneumococci form a group of organisms of which the individual strains exhibit wide differences in character. Like the streptococci, certain types of which they closely resemble, they show a variability in their predilections and behaviour bewildering to those who are attempting to classify them. Not only are pneumococci known to cause a great variety of lesions about the body, but they have also been found in the throats of a large proportion of healthy persons who apparently suffer no inconvenience from their presence—Stillman (1916, 1917), Glynn (1923) and others.

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References

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Armstrong, R. R. (1921). The Serological Characters of Disease-producing Pneumococci. Brit. Med. J. 1, 259.
Armstrong, R. R. (1922). Application of the Absorption of Agglutinin Test to the Serological Study of Pneumococci. Brit. J. Exp. Path. 3, 287.
Armstrong, R. R. (1923). The Correlation of Clinical Manifestations and Serological Types in Pneumococci. St Bartholomew's Hosp. Rep. 56, 85.
Avery, O. T. and Dochez, A. R. (1915). The Occurrence of Carriers of Disease-producing Types of Pneumococci. J. Exp. Med. 22, 105.
Foster, M. and Gaskell, J. F. (1916). Gerebro-spinal Fever, pp. 123 et seq. (Camb. Univ. Press.)
Gaskell, J. F. (1925). Experimental Pneumococcal Infections of the Lung. J. Path, and Bact. 28, 427.
Glynn, E. E. and Digby, L. (1923). Bacteriological and Clinical Observations on Pneumonia and Empyemata, with Special Reference to the Pneumococcus and to Serum Treatment. Med. Res. Council, Special Report Series, No. 79.
Griffith, F. (1923). The Influence of Immune Serum on the Biological Properties of Pneumococci. Reports on Public Health and Medical Subjects, No. 18, p. 9.
Griffith, F. (1928). The Significance of Pneumococcal Types. J. Hygiene, 27, 113.
Lister, F. S. (1913). Specific Serological Reactions with Pneumococci from Different Sources. Publications of the S. African Inst.for Med. Research, Johannesburg, Dec. 22, 1.
Reimann, H. A. (1925). Variations in Specificity and Virulence of Pneumococci during Growth in vitro. J. Exp. Med. 41, 599.
Stillman, E. G. (1916). A Contribution to the Epidemiology of Lobar Pneumonia. J. Exp. Med. 24, 651.
Stillman, E. G. (1917). Further Studies on the Epidemiology of Lobar Pneumonia. J. Exp. Med. 26, 513.
Whittle, C. H. (1927). The Determination of Virulence of Pneumoeocci Freshly Isolated from Human Lesions. J. Path, and Bact. 21, 305.
Whittle, C. H. (1928). On the Identification of Pneumococci, and the Tests Employed for Distin guishing them from Streptococci. J. Hygiene, 27, 200.

The Relation of Virulence in Pneumococci to Disease, with a Comparison of Virulence of the Different Types of Pneumococci in various Pathological Conditions

  • C. H. Whittle (a1)

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