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Reinfection after successful eradication of Helicobacter pylori in three different populations in Alaska

  • M. G. BRUCE (a1), D. L. BRUDEN (a1), J. M. MORRIS (a1), A. L. REASONOVER (a1), F. SACCO (a2), D. HURLBURT (a1), T. W. HENNESSY (a1), J. GOVE (a3), A. PARKINSON (a1), G. SAHAGUN (a4), P. DAVIS (a2), J. KLEJKA (a5) and B. J. McMAHON (a1) (a3)...

Summary

We performed a study to determine rates of reinfection in three groups followed for 2 years after successful treatment: American Indian/Alaska Native (AI/AN) persons living in urban (group 1) and rural (group 2) communities, and urban Alaska non-Native persons (group 3). We enrolled adults diagnosed with H. pylori infection based on a positive urea breath test (13C-UBT). After successful treatment was documented at 2 months, we tested each patient by 13C-UBT at 4, 6, 12 and 24 months. At each visit, participants were asked about medication use, illnesses and risk factors for reinfection. We followed 229 persons for 2 years or until they became reinfected. H. pylori reinfection occurred in 36 persons; cumulative reinfection rates were 14·5%, 22·1%, and 12·0% for groups 1, 2, and 3, respectively. Study participants who became reinfected were more likely to have peptic ulcer disease (P = 0·02), low education level (P = 0·04), or have a higher proportion of household members infected with H. pylori compared to participants who did not become reinfected (P = 0·03). Among all three groups, reinfection occurred at rates higher than those reported for other US populations (<5% at 2 years); rural AI/AN individuals appear to be at highest risk for reinfection.

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Corresponding author

* Author for correspondence: M. G. Bruce, MD, MPH, Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging Zoonotic and Infectious Diseases, CDC, Anchorage, AK 99508, USA. (Email: zwa8@cdc.gov)

References

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Keywords

Reinfection after successful eradication of Helicobacter pylori in three different populations in Alaska

  • M. G. BRUCE (a1), D. L. BRUDEN (a1), J. M. MORRIS (a1), A. L. REASONOVER (a1), F. SACCO (a2), D. HURLBURT (a1), T. W. HENNESSY (a1), J. GOVE (a3), A. PARKINSON (a1), G. SAHAGUN (a4), P. DAVIS (a2), J. KLEJKA (a5) and B. J. McMAHON (a1) (a3)...

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