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Qualitative or Quantitative Methods in the Serological Diagnosis of Enteric Infections?

Published online by Cambridge University Press:  15 May 2009

E. S. Horgan
E. S. Horgan
Affiliation:
Government Bacteriologist, WellcomeTropical Research Laboratories, Khartoum.
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1. “Normal” agglutinins for B. typhosus and B. paratyphosus B appear to be conclusively of the O type.

2. Such agglutinins appear to be of consistently low titre and are absent in many sera.

3. Normal agglutinins for B. paratyphosus A have not been encountered.

4. O agglutinins are readily produced by inoculation of a T.A.B. vaccine, and may rise to as high titres as those encountered during an enteric infection.

5. It is impossible to fix any limit for residual O agglutinins in inoculated persons.

6. The value of examining for O agglutinins in enteric cases is confirmed.

7. Some fallacies of a purely qualitative method are pointed out, and a plea is made for the inclusion of the principles of qualitative receptor analysis in a quantitative Widal.

Type
Research Article
Information
Journal of Hygiene , Volume 32 , Issue 4 , October 1932 , pp. 523 - 528
Copyright
Copyright © Cambridge University Press 1932

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