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Purified chick embryo cell rabies vaccine: economical multisite intradermal regimen for post-exposure prophylaxis

Published online by Cambridge University Press:  19 October 2009

Pravan Suntharasamai ,
M. J. Warrell ,
Chaisin Viravan ,
Pornthep Chanthavanich ,
Sornchai Looareesuwan ,
Achara Supapochana ,
Juntra Karbwang Wichai Supanaranond ,
Sunee Chittamas ,
U. Bijok  and
D. A. Warrell
Pravan Suntharasamai
Affiliation:
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Sir William Dunn School of Pathology and Nuffield Department of Clinical Medicine, Oxford University, U.K., and Behring Research Laboratories, Marburg, West Germany
M. J. Warrell
Affiliation:
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Sir William Dunn School of Pathology and Nuffield Department of Clinical Medicine, Oxford University, U.K., and Behring Research Laboratories, Marburg, West Germany
Chaisin Viravan
Affiliation:
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Sir William Dunn School of Pathology and Nuffield Department of Clinical Medicine, Oxford University, U.K., and Behring Research Laboratories, Marburg, West Germany
Pornthep Chanthavanich
Affiliation:
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Sir William Dunn School of Pathology and Nuffield Department of Clinical Medicine, Oxford University, U.K., and Behring Research Laboratories, Marburg, West Germany
Sornchai Looareesuwan
Affiliation:
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Sir William Dunn School of Pathology and Nuffield Department of Clinical Medicine, Oxford University, U.K., and Behring Research Laboratories, Marburg, West Germany
Achara Supapochana
Affiliation:
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Sir William Dunn School of Pathology and Nuffield Department of Clinical Medicine, Oxford University, U.K., and Behring Research Laboratories, Marburg, West Germany
Juntra Karbwang Wichai Supanaranond
Affiliation:
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Sir William Dunn School of Pathology and Nuffield Department of Clinical Medicine, Oxford University, U.K., and Behring Research Laboratories, Marburg, West Germany
Sunee Chittamas
Affiliation:
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Sir William Dunn School of Pathology and Nuffield Department of Clinical Medicine, Oxford University, U.K., and Behring Research Laboratories, Marburg, West Germany
U. Bijok
Affiliation:
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Sir William Dunn School of Pathology and Nuffield Department of Clinical Medicine, Oxford University, U.K., and Behring Research Laboratories, Marburg, West Germany
D. A. Warrell
Affiliation:
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Sir William Dunn School of Pathology and Nuffield Department of Clinical Medicine, Oxford University, U.K., and Behring Research Laboratories, Marburg, West Germany
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The standard six-dose intramuscular (i.m.) rabies post-exposure vaccine regimen using a new purified chick embryo cell (PCEC) vaccine was compared with two economical multisite intradermal (i.d.) PCEC regimens, a multisite i.m. PCEC schedule and a subcutaneous regimen using a suckling mouse brain (SMB) rabies vaccine manufactured in Thailand. The neutralizing antibody results for the four-site and eight-site i.d. and the standard i.m. PCEC regimens were similar over 3 months. A three-site i.m. PCEC regimen had no advantage. The SMB vaccine gave the lowest antibody levels. Human rabies immune globulin therapy significantly increased the GMT of all groups on day 7, unlike equine antirabies serum (EARS). Both antisera suppressed antibody responses to PCEC on days 14 and 28. Three generalized reactions probably related to EARS were the only serious side effects. An eight-site i.d. PCEC vaccine regimen proved as immunogenic as the routine i.m. schedule and, if implemented as post-exposure prophylaxis, would be the cheapest widely available tissue culture vaccine regimen. The protective efficiency should now be tested in patients bitten by rabid animals.

Type
Research Article
Information
Epidemiology & Infection , Volume 99 , Issue 3 , December 1987 , pp. 755 - 765
Copyright
Copyright © Cambridge University Press 1987

References

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