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Protection from natural infection after live influenza virus immunization in an open population*

  • G. Rocchi (a1), L. Carlizza (a1), M. Andreoni (a1), G. Ragona (a1), C. Piga (a1), A. Pelosio (a1), A. Volpi (a1) and A. Muzzi (a2)...

Summary

Live attenuated influenza vaccine containing the recombinant of A/Victoria/3/75 with A/PR/8/34 virus was administered to healthy adults in a field trial aimed at evaluating protection provided by immunization. The study was designed to measure the effect of vaccination on absenteeism from respiratory disease during a natural influenza epidemic. A total of 2115 male employees of the public transport service of Rome volunteered to participate in the trial, 1050 and 1065 receiving vaccine and placebo respectively, in a randomized blind fashion. Vaccination procedure was completed by the end of December 1976. A small-sized outbreak of influenza, due to a viral strain antigenically homologous to the vaccine, occurred during the month of February 1977. Analysis of absenteeism data, classified according to medical certificate, indicated that morbidity from respiratory disease was reduced in vaccinees compared with controls during the epidemic month; the rate of increase of morbidity compared with that of the preceding month was then three times lower in vaccinees than in controls and the difference in absenteeism between the two groups greatly exceeded the ordinary fluctuation that was observed during non-epidemic periods.

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References

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Alexandrova, G. I., Smorodintsev, A. A., Beljaeva, N. M., Vasil'ev, B., Geft, R. A., Panteleev, V. G., Siefer, M. A. & Selivanov, A. A. (1970). Testing the safety and effectiveness of oral administration of a live influenza vaccine. Bulletin of the World Health Organization 42, 429.
Beare, A. S., Habershon, R. B., Tyrrell, D. A. J. & Hall, T. S. (1973). Recombinant live influenza vaccine virus; tests of transmissibility in man. Journal of Biological Standardization 1, 233.
Crifò, S., Filiaci, F., Pelosio, A. & Roccni, G. (1978). Risposta secretoria e sierica dopo vaccinazione antiinfluenzale per via nasale con virus vivo attenuato A/Victoria/3/75. Bollettino della Società Italiana di Biologia Sperimentale (in the Press).
Donikian, M. A., McKee, J. & Greene, L. C. (1977). Challenge versus natural infection as an index of protection after influenza immunization. Developments in Biological Standardization 39, 149.
Ikic`, D., Pasini, N., Hec`imovic`, M., Juzbašić, M., Smerdel, S., Rajner, N. & Jelavić, V. (1977). Attenuation of influenza A/New Jersey/76 virus strain, preparation of live vaccine and vaccine reactogenicity in volunteers. Developments in Biological Standardization 39, 61.
Kunz, C. H. & Hofmann, H. (1977). Field study with a live influenza vaccine (RIT 4050) in children. Developments in Biological Standardization 39, 93.
Lobmann, M., Delem, A. & Jovanovic, D. (1977). Properties of A/Victoria/3/75 recombinants: development of an attenuated strain RIT 4050. Developments in Biological Standardization 39, 43.
MacKenzie, J. S., MacKenzie, I., Lloyd, J. & Dent, V. (1975). Comparative trials of live attenuated and detergent split influenza virus vaccines. Journal of Hygiene 75, 425.
McDonald, J. C., Zuckerman, A. J., Beare, A. S. & Tyrrell, D. A. J. (1962). Trials of live influenza vaccine in the Royal Air Force. British Medical Journal i, 1036.
Minor, T. E., Dick, E. C., Dick, R. C. & Inhorn, S. L. (1975). Attenuated influenza A vaccine (Alice) in an adult population: Vaccine-related illness, serum and nasal antibody production and intrafamily transmission. Journal of Clinical Microbiology 2, 403.
Munphy, B. R., Chalbub, E. G., Nusinoff, S. R. & Chanock, R. M. (1972). Temperature-sensitive mutants of influenza virus. II. Attenuation of ts recombinants for man. Journal of Infectious Diseases 126, 170.
Nicholson, K. G., Lawford, C. V. P. & Tyrrell, D. A. J. (1977). Studies of respiratory function in volunteers given live influenza virus vaccine. Developments in Biological Standardization 39, 129.
Noble, G. B., Corey, L., Rosenberg, R. L., Hoke, K., Brown, W. J., Kaye, H. S., Bregman, D. J., Gregg, M. B. & Dowdle, W. R. (1975). An open field trial of live attenuated influenza A/England/42/72 (H3N2) vaccine. II. Illness and infection rates during an epidemic of A/Port Chalmers/-like influenza. 15th Interscience Conference on Antimicrobial Agents and Chemotherapy,Washington, D.C. (abstract).
Petrilli, F. L., Crovari, P., Crovai-Cuneo, P., Badolati, G. & Canepa, R. (1975). Oral influenza vaccination with live attenuated viruses. I. Acceptability, immunogenicity and transmissibility. Bollettino dell'Istituto Sieroterapico Milanese 54, 312.
Prèvost, J. M., Peetermans, J., Lamy, F. & Huygelen, C. (1973). Immune response to vaccination with a live influenza virus (H3N2) vaccine (‘Ann’ strain). Infection and Immunity 8, 420,
Ragona, G., Giunchi, G., Rocchi, G., Muzzi, A. & De Felici, A. (1978). Excess mortality from influenza in a large urban population, Rome, Italy, 1956–76. Journal of Hygiene 80, 249.
Rubin, R. G., Noble, G. R., Corey, L., Brown, W. J., Brandling-Bennett, D., Kaye, H. S., Coleman, M. T., Gregg, M. B. & Dowdle, W. R. (1976). Live, attenuated influenza A/England/42/72 (H3N2) virus vaccine: a field trial. Journal of Infectious Diseases 133, 603.
Rytel, M. W., Jackson, L. J., Ferstenfeld, J. E. & Rosenkranz, M. A. (1975). New live attenuated influenza A/England/42/72 (H3N2) vaccine (Alice): reactogenicity, immunogenicity, and protection efficacy. Journal of Infectious Diseases 132, 652.
Rytel, M. W., Jackson, L. J., Niebojewski, R. A., Haagensen, J. L. & Rosenkranz, M. A. (1977). Field trial of live attenuated influenza A/B (‘Alice’/R-75) vaccine. American Journal of Epidemiology 105, 49.
Serfling, R. E. (1963). Methods for current statistical analysis of excess pneumonia-influenza deaths. Public Health Reports 78, 494.
Sever, J. L. (1962). Application of a microtechnique to viral serological investigations. Journal of Immunology 88, 320.

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