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Prevalence of transmitted drug resistance among HIV-1 treatment-naive patients in Beijing

  • Y.X. Song (a1), R.L. Xin (a2), Z.C. Li (a1), H.W. Yu (a1), W.H. Lun (a3), J. Ye (a1), A. Liu (a1), A.X. Li (a1), J.W. Li (a1), J.Z. Ye (a1), M.Q. Hao (a2), H.Y. Lu (a2) and L.J. Sun (a1)...

Abstract

To optimise patients’ outcomes and gain insight into transmitted drug resistance (TDR) among human immunodeficiency virus (HIV)-1 treatment-naive patients in Beijing, the prevalence of TDR was assessed. Demographic and clinical data of 1241 treatment-naive patients diagnosed between April 2014 and February 2015 were collected. TDR was defined using the Stanford University HIV drug resistance mutations database. The risk factors were evaluated by multi-logistic regression analysis. Among 932 successfully amplified cases, most were male (96.78%) and infected through men having sex with men (91.74%). Genotype were CRF01_AE (56.44%), B (20.60%), CRF07_BC (19.96%), C (1.61%) and other genotypes (1.39%). The overall prevalence of TDR was 6.12%. Most frequent mutations occurred in non-nucleoside reverse transcriptase inhibitors (NNRTIs) (3.11%), followed by protease inhibitors (PIs) (2.25%) and nucleoside reverse transcriptase inhibitors (NRTIs) (1.32%). Furthermore, HIV-1 genotype was associated with high risk of resistance, in which genotype C and other genotype may have higher risk for resistance. The prevalence among treatment-naive patients in Beijing was low. Resistance to NNRTIs was higher than with PIs or NRTIs. Continuous monitoring of regional levels of HIV-1 TDRs would contribute to improve treatment outcomes and prevent failures.

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Copyright

Corresponding author

Author for correspondence: L.J. Sun, E-mail: sunlijunkity@163.com

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These authors contributed equally for this study

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References

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