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The prevalence of HSV-2 infection in HIV-1 discordant couples

  • S. DUAN (a1), Y. DING (a2), Z. WU (a3), K. ROU (a3), Y. YANG (a1), J. WANG (a1), M. GAO (a2), R. YE (a1), L. XIANG (a1) and N. HE (a2)...

Summary

We aimed to investigate the prevalence and associated factors of HSV-2 discordance and concordance in HIV-1-discordant couples. This study used the baseline data from a cohort study of HIV-1-discordant couples in Dehong prefecture of Yunnan province, China. Of 954 participating couples, 42·4% were affected by HSV-2, of which 20·4% were HSV-2-concordant positive, 7·6% were HSV-2-discordant where the male was HSV-2 positive, and 14·4% were HSV-2 discordant where the female was HSV-2 positive. Compared to HSV-2-negative concordance, HSV-2 discordance with an HSV-2-positive male spouse was significantly associated with characteristics of the male spouse, including Han ethnicity and being in a second marriage. HSV-2 discordance with an HSV-2-positive female spouse was significantly associated with characteristics of the female spouse, including Han ethnicity, having engaged in commercial sex, having a sexual relationship of <3 years and being HIV-1 infected. Compared to HSV-2 discordance, HSV-2-positive concordance was significantly associated with an education level of middle school or higher for both spouses, a sexual relationship of ⩾3 years, more frequent sex and having an HIV-1-infected male spouse. The findings highlight the need for HSV-2 prevention and treatment efforts to reduce HSV-2 transmission in this population, and emphasize the importance of implementing prevention interventions early in couples' relationships.

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Copyright

Corresponding author

* Author for correspondence: N. He, MD, PhD, Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China, 200032. (Email: nhe@shmu.edu.cn)

References

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