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Persistence of measles neutralizing antibody related to vaccine and natural infection acquired before HIV infection

  • M. B. ISA (a1) (a2), J. V. PAVAN (a1), P. SICILIA DON (a1), S. GRUTADAURIA (a3), L. C. MARTINEZ (a1), M. O. GIORDANO (a1), G. MASACHESSI (a1) (a4), P. A. BARRIL (a1) (a4) and S. V. NATES (a1)...

Summary

Little is known about long-lasting measles protective immunity when exposure to wild-type or vaccine measles virus precedes HIV infection. The results obtained suggest that measles immunity wanes and the lowest measles geometric mean titres (GMT) were significantly associated with measles vaccine-induced immunity in individuals that later developed HIV infection (86% prevalence, GMT 164 mIU/ml) compared to naturally induced immunity in HIV-infected adults (100% prevalence, GMT 340 mIU/ml, P = 0·0082) or non-HIV infected adults (100%, GMT 724 mIU/ml, P = 0·0001), and vaccine-induced immunity in non-HIV-infected adults (100%, GMT 347 mIU/ml, P = 0·017). The study was conducted in an area without wild-type virus circulation since 2000. The absence of virus circulating may alter the paradigm of lifelong immunity to measles virus after vaccination. As the proportion of HIV-infected individuals possessing only vaccine-induced immunity continues to grow, checking the status of measles immunity in this group is strongly recommended.

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Copyright

Corresponding author

*Author for correspondence: J. V. Pavan, MD, PhD, Virology Institute ‘Dr J. M. Vanella’, School of Medical Sciences, National University of Córdoba, Córdoba, Argentina. (Email: jorgevpavan@gmail.comorjpavan@mater.fcm.unc.edu.ar)

References

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