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Performance of an interferon-gamma release assay for diagnosing latent tuberculosis infection in children

  • K. OKADA (a1) (a2), T. E. MAO (a3), T. MORI (a2) (a4), T. MIURA (a1) (a2), T. SUGIYAMA (a1) (a2), T. YOSHIYAMA (a2), S. MITARAI (a2), I. ONOZAKI (a2), N. HARADA (a2), S. SAINT (a3), K. S. KONG (a1) and Y. M. CHHOUR (a5)...

Summary

Newly developed interferon-gamma release assays have become commercially available to detect tuberculosis (TB) infection in adults. However, little is known about their performance in children. We compared test results between the QuantiFERON-TB® Gold test (QFT) and tuberculin skin test (TST) in young children living with pulmonary TB patients in Cambodia. Of 195 children tested with both QFT and TST, the TST-positive rate of 24% was significantly higher than the QFT-positive rate of 17%. The agreement between the test results was considerable (κ-coefficient 0·63). Positive rates increased from 6% to 32% for QFT and from 15% to 43% for TST, according to the sputum smear grades of the index cases. The presence of Bacille Calmette-Guérin (BCG) scars did not significantly affect the results of TST or QFT in a logistic regression analysis. In conclusion, QFT can be a substitute for TST in detecting latent TB infection in childhood contacts aged ⩽5 years, especially in those who may have a false-positive TST due to BCG vaccination or non-tuberculous mycobacterial infection.

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Copyright

Corresponding author

*Author for correspondence: Dr K. Okada, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association – International Cooperation, 3-1-24 Matsuyama Kiyose-shi, Tokyo 204-8533, Japan. (Email: okadak@jata.or.jp)

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Performance of an interferon-gamma release assay for diagnosing latent tuberculosis infection in children

  • K. OKADA (a1) (a2), T. E. MAO (a3), T. MORI (a2) (a4), T. MIURA (a1) (a2), T. SUGIYAMA (a1) (a2), T. YOSHIYAMA (a2), S. MITARAI (a2), I. ONOZAKI (a2), N. HARADA (a2), S. SAINT (a3), K. S. KONG (a1) and Y. M. CHHOUR (a5)...

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