Skip to main content Accessibility help
×
Home

Para-influenza 2 virus infections in adult volunteers

  • D. Taylor-Robinson (a1) and M. L. Bynoe (a1)

Extract

Twenty-eight adult volunteers were inoculated intranasally with para influenza 2 virus and eight developed illnesses; twenty-eight volunteers were given flanks' saline and one became ill. The illnesses occurred in volunteers given between 2 × 104 and 2 × 106 TCD 50 of virus. The most prominent symptoms were sore throat, nasal stuffiness and coryza; four of the eight volunteers had sufficient coryza to be regarded as having mild colds. Although only eight volunteers had clinical evidence of infection, twenty-four had laboratory evidence of infection as judged by virus re-isolation or antibody response. Neutralization, haemagglutination-inhibition and complement-fixation tests on paired sera showed that sixteen individuals had a fourfold or greater antibody response by one or more tests including five of the eight volunteers who were ill. Twenty volunteers, including seven who were ill, had reciprocal neutralizing antibody titres of eight or more before inoculation of virus so it seems that the illnesses were due to re infection in the presence of antibody. Evidence is presented which suggests that although illnesses occurred in the presence of antibody they were due to the para influenza 2 virus and not some other agent in the inoculum. The results of these experiments seem to fulifi the third of Koch's postulates for para-influenza 2 virus as a cause of respiratory disease in adults.

We wish to thank Dr P. A. J. Tyrreil for his advice during the course of this work and in the preparation of the manuscript. We also thank Dr K. V. Shah (The Johns Hopkins University, Baltimore, U.S.A.) for help in some of the early experiments and Miss B. Ridgwell for valuable technical assistance.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Para-influenza 2 virus infections in adult volunteers
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Para-influenza 2 virus infections in adult volunteers
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Para-influenza 2 virus infections in adult volunteers
      Available formats
      ×

Copyright

References

Hide All
Andrewes, C. H. (1948). The common cold. J. R. Soc. Arts. 96, 200.
Chanock, R. M. (1956). Association of a new type of cytopathogenic myxovirus with infantile croup. J. exp. Med. 104, 555.
Chanock, R. M., Bell, J. A. & Parrott, B. H. (1961). Natural history of para-influenza infection. Perspectives in Virology, 2, 126.
Chanock, R. M., Kim, H. W., Vargosko, A. J., Deleva, A., Johnson, K. M., Cumming, C. & Parrott, R. H. (1961). Respiratory syncytial virus. I. Virus recovery and other obser vations during 1960 outbreak of bronchiolitis, pneumonia, and minor respiratory diseases in children. J. Amer. med. Assoc. 176, 647.
Chanock, R. M., Paitrott, R. H., Cook, K., Andrews, B. E., Bell, J. A., Reichelderfer, T. E., Kapikian, A. Z., Mastrota, F. M. & Huebner, R. J. (1958). Newly recognized myxoviruses from children with respiratory disease. New Eng. J. Med. 258, 207.
Dick, E. C., Mogabgab, W. J. & Holmes, B. (1961). Characteristics of para-infiuenza (HA-2) virus. I. Incidence of infection and clinical features in adults. Amer. J. Hyg. 73, 263.
Evans, A. S. (1960). Infections with hemadsorption virus in University of Wisconsin students. New Eng. J. Med. 263, 233.
Hamre, D. & Procknow, J.J. (1961). Viruses isolated from natural common colds in the U.S.A. Brit. med. J. ii, 1382.
Heath, R. B., Tyrrell, D. A. J. & Peto, S. (1962). Serological studies with Sendai virus. Brit. J. exp. Path. 43, 444.
Holland, W. W., Tanerr, E. I., Pereira, M. S. & Taylor, C. E. D. (1960). A study of the aetiology of respiratory disease in a general hospital. Brit. med. J. i, 1917.
Kapikian, A. Z., Chanock, R. M., Reichelderfer, T. E., Ward, T. G., Huebner, R. S., Bell, J. A. (1961). Inoculation of human volunteers with para-influenza virus type 3. J. Amer. med. Assoc. 178, 537.
Kim, H. W., Vargosko, A. J., Chanock, R. M. & Pareott, R. H. (1961). Para-influenza (CA) virus: etiologic association with croup. Pediatrics, 28, 614.
Kravetz, H. M., Knight, V., Chanock, R. M., Morris, J. A., Johnson, K. M., Rifkind, D. & Utz, J. P. (1961). Respiratory syncytial virus. III. Production of illness and clinical observations in adult volunteers. J. Amer. med. Assoc. 176, 657.
Mogabgab, W. J., Dick, E. C. & Holmes, B. (1961). Para-influenza 2 (CA) virus in young adults. Amer. J. Hyg. 74, 304.
Paarott, R. H., Vargosko, A. J., Kim, H. W., Bell, J. A. & Chanock, R. M. (1962). Acute respiratory diseases of viral etiology. III. Myxoviruses: para-influenza. Amer. J. pubi. Hith, 52, 907.
Reichelderfer, T. E., Chanock, R. M., Craighead, J. E., Huebner, R. J., Turner, H. C., James, W. & Waiw, T. G. (1958). Infection of human volunteers with type 2 hemadsorption virus. Science, 128, 779.
Roden, A. T. (1958). Clinical assessment of the common cold. Proc. R. Soc. Med. 51, 271.
Takátsy, G. (1955). The use of spiral loops in serological and virological micro-methods. Acta microbiol. Acad. Sir., Hung. 3, 191.
Tyrrell, D. A. J., Bynoe, M. L., Birkum Petersen, K., Sutton, R. N. P. & Pereira, M. S. (1959). Inoculation of human volunteers with para-influenza viruses types 1 and 3 (HA2 and HA1). Lancet, ii, 909.
Vogel, J. & Shalokov, A. (1957). Adsorption-hemagglutination test for influenza virus in monkey kidney tissue culture. Science 126, 358.

Para-influenza 2 virus infections in adult volunteers

  • D. Taylor-Robinson (a1) and M. L. Bynoe (a1)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed