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Novel HPV-6 variants of human papillomavirus causing recurrent respiratory papillomatosis in southern Africa

  • C. E. COMBRINCK (a1), R. Y. SEEDAT (a2), C. RANDALL (a1), Y. ROODT (a1) and F. J. BURT (a1) (a3)...

Summary

There is currently no information regarding the genetic diversity of HPV-6 variants circulating in South Africa. The aim of this study was to determine the HPV-6 variants affecting patients with recurrent respiratory papillomatosis, to determine whether mutations correlate with disease severity and identify molecular determinants of virulence with prognostic relevance. HPV-6 variants were identified based on genome changes within the 712-991 bp region encompassing the non-coding region (URR) of the genome, with variations in length resulting from insertions and duplications, and the 453-bp gene encoding the E6 protein. Based on manual comparison of sequence data from the URR, the isolates were identified as HPV-6a and HPV-6vc variants. Three novel HPV-6 variants were identified: one based on a mutation in the E6 region; two based on changes in the URR including a unique substitution detected in three isolates and an insertion and 170-bp duplication in the URR genome in one patient, who had clinical features of severe disease.

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Copyright

Corresponding author

*Author for correspondence: Professor F. J. Burt, Department of Medical Microbiology and Virology, National Health Laboratory Services Universitas and Faculty of Health Science, University of the Free State, Bloemfontein, South Africa. (Email: burtfj@ufs.ac.za)

References

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Keywords

Novel HPV-6 variants of human papillomavirus causing recurrent respiratory papillomatosis in southern Africa

  • C. E. COMBRINCK (a1), R. Y. SEEDAT (a2), C. RANDALL (a1), Y. ROODT (a1) and F. J. BURT (a1) (a3)...

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