Hostname: page-component-77c89778f8-n9wrp Total loading time: 0 Render date: 2024-07-20T07:59:43.687Z Has data issue: false hasContentIssue false
  • English
  • Français

The neutralization of pox viruses I. Evidence for antibody interference

Published online by Cambridge University Press:  15 May 2009

T. A. McNeill
T. A. McNeill
Affiliation:
Department of Microbiology, The Queen's University of Belfast
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Evidence was presented to support a hypothesis that competition between antibody molecules can be an important factor in vaccinia virus neutralization.

It has been shown that there is little difference in the virus neutralizing properties of 7 S and 19 S antibody and it has been further postulated that in the context of protective immunity the proportions of antibodies having neutralizing and interfering effects is likely to be more important than the absolute concentration of neutralizing antibody or the type of immunoglobulin in which it is present.

Type
Research Article
Information
Journal of Hygiene , Volume 66 , Issue 4 , December 1968 , pp. 541 - 548
Copyright
Copyright © Cambridge University Press 1968

References

REFERENCES

Appleyard, G. & Westwood, J. C. N. (1964). A protective antigen from the pox viruses. II. Immunization of animals. Br. J. exp. Path. 45, 162.Google ScholarPubMed
Bradish, C. J., Farley, J. O. & Ferrier, H. E. N. (1962). Studies on the nature of the neutralization reaction and the competition for neutralizing antibody between components of the virus system of foot-and-mouth disease. Virology 18, 378.CrossRefGoogle ScholarPubMed
Dulbecco, R., Vogt, M. & Strickland, A. G. R. (1956). A study of the basic aspects of neutralization of two animal viruses, Western equine encephalitis virus and poliomyelitis virus. Virology 2, 162.CrossRefGoogle ScholarPubMed
Fazekas de St Groth, S. & Reid, A. F. (1958). The neutralization of animal viruses. II. A critical comparison of hypotheses. J. Immun. 80, 225.CrossRefGoogle Scholar
Lafferty, K. J. (1963). The interaction betweenvirus and antibody. I. Kinetic studies. Virology 21, 61.CrossRefGoogle Scholar
McNeill, T. A. (1965). The antibody response of rabbits to inactivated vaccinia virus. J. Hyg., Camb. 63, 525.Google ScholarPubMed
McNeill, T. A. (1966). The development of skin resistance and hypersensitivity following inactivated vaccinia virus vaccines in rabbits. J. Hyg., Camb. 64, 23.CrossRefGoogle ScholarPubMed
Wallis, C. & Melnick, J. L. (1967). Virusaggregation as the cause of the non-neutralizable persistent fraction. J. Virol. 1, 478.CrossRefGoogle ScholarPubMed