Skip to main content Accessibility help
×
Home

Influence of thyroid hormone disruption on the incidence of shingles

  • A. AJAVON (a1), D. KILLIAN (a1) (a2), R. ODOM (a2), R. W. FIGLIOZZI (a1), F. CHEN (a1), M. BALISH (a1), J. PARMAR (a1), R. FREEMAN (a1), J. SNITZER (a2) and S. V. HSIA (a1)...

Summary

The reactivation of dormant alpha-human herpesvirus (αHHV) has been attributed to various causes often referred to as stressors. However, no clinical study investigating the relationship between stressors and reactivation exists in humans at this time. Herpes simplex virus type-1 (HSV-1), an important αHHV, was shown to have its gene expression and replication regulated by thyroid hormone (TH) using molecular biology approaches. Varicella zoster virus (VZV) is categorized in αHHV superfamily and shares similar homology with HSV-1. We hypothesize that a history of TH imbalance may be associated with the incidence of shingles (VZV reactivation). This current pilot study, based on a hospital medical claims database, was conducted as a retrospective case-controlled investigation to determine if a putative link between TH imbalance and incidence of shingles is present. An odds ratio of 2·95 with a χ 2 value of 51·74 was calculated for the total population diagnosed with TH disruption and shingles. Further analyses indicated that African American males exhibited a much higher chance of simultaneous diagnoses. These results show that a TH imbalance history may affect VZV reactivation at different incidence rates in different races and age groups.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Influence of thyroid hormone disruption on the incidence of shingles
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Influence of thyroid hormone disruption on the incidence of shingles
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Influence of thyroid hormone disruption on the incidence of shingles
      Available formats
      ×

Copyright

Corresponding author

* Address for correspondence: S. V. Hsia, PhD, Department of Pharmaceutical Sciences, University of Maryland Eastern Shore, School of Pharmacy and Health Professions, 1 College Backbone Road, Princess Anne, MD 21853 USA. (Email: vhsia@umes.edu)

References

Hide All
1. Lazar, MA. Thyroid hormone action: a binding contract. Journal of Clinical Investigation 2003; 112: 497499.
2. Shi, YB, et al. Thyroid hormone regulation of apoptotic tissue remodeling during anuran metamorphosis. Cell Research 2001; 11: 245252.
3. Hsia, SC, Shi, YB. Chromatin disruption and histone acetylation in regulation of the human immunodeficiency virus type 1 long terminal repeat by thyroid hormone receptor. Molecular and Cellular Biology 2002; 22: 40434052.
4. Hsia, SC, et al. Role of chromatin disruption and histone acetylation in thyroid hormone receptor action: implications in the regulation of HIV-1 LTR. Histology and Histopathology 2003; 18: 323331.
5. Hsia, SC, Wang, H, Shi, YB. Involvement of chromatin and histone acetylation in the regulation of HIV-LTR by thyroid hormone receptor. Cell Research 2001; 11: 816.
6. Bedadala, GR, et al. Thyroid hormone controls the gene expression of HSV-1 LAT and ICP0 in neuronal cells. Cell Research 2010; 20: 587598.
7. Hsia, SC, et al. Regulation of herpes simplex virus type 1 thymidine kinase gene expression by thyroid hormone receptor in cultured neuronal cells. Journal of Neurovirology 2010; 16: 1324.
8. Fields, BN, et al. (eds). Fields' Virology, 5th edn. Philadelphia, Pennsylvania: Lippincott Williams & Wilkins, 2007.
9. Martinez, PA, et al. The effect of highly active antiretroviral therapy on outcome of central nervous system herpesviruses infection in Cuban human immunodeficiency virus-infected individuals. Journal of Neurovirology 2007; 13: 446451.
10. Goel, N, et al. The ability of an HSV strain to initiate zosteriform spread correlates with its neuroinvasive disease potential. Archives of Virology 2002; 147: 763773.
11. Hsia, SC, Bedadala, GR, Balish, MD. Effects of thyroid hormone on HSV-1 gene regulation: implications in the control of viral latency and reactivation. Cell & Bioscience 2011; 1: 24.
12. Hsia, SH, Hsia, SCV. A cohort historical analysis of the relationship between thyroid hormone malady and alpha-human herpesvirus activation. Journal of Steroids & Hormonal Science 2014; 5: 17.
13. Gilden, D, Nagel, MA, Cohrs, RJ. Varicella-zoster. Handbook of Clinical Neurology 2014; 123: 265283.
14. Figliozzi, RW, et al. Thyroid hormone-dependent epigenetic suppression of herpes simplex virus-1 gene expression and viral replication in differentiated neuroendocrine cells. Journal of the Neurological Sciences 2014; 346: 164173.

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed