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Increase in meningococcal disease associated with the emergence of a novel ST-11 variant of serogroup C Neisseria meningitidis in Victoria, Australia, 1999–2000

  • D. E. TRIBE (a1), A. M. ZAIA (a2), J. M. GRIFFITH (a2), P. M. ROBINSON (a3), H. Y. LI (a2), K. N. TAYLOR (a3) and G. G. HOGG (a2)...

Abstract

In the years 1999–2000, there was an increase in the incidence of meningococcal disease in Victoria, largely caused by Neisseria meningitidis serogroup C. This change was associated with a shift in age distribution of cases, with relatively more disease appearing in the 15–29 year age group, and with 40/58 serogroup C isolates in 2000 exhibiting a new macrorestriction pattern (pattern A). Thirty-four of 52 pattern A isolates tested displayed the novel phenotype C:2a:P1.4, and were consistently porA VR type P1.7-2,4 by DNA sequencing. Nine of 10 representative pattern A isolates analysed displayed a housekeeping gene allele profile (ST-11) that is characteristic of the electrophoretic type (ET)-15 variant that has caused outbreaks in Canada, the Czech Republic and Greece. Meningococci belonging to the ST-11 complex that were isolated in Victoria prior to 1999 did not display either restriction pattern A or PorA VR type P1.7-2,4.

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Copyright

Corresponding author

Author for correspondence: Microbiological Diagnostic Unit, Public Health Laboratory, Department of Microbiology and Immunology, University of Melbourne, VIC 3010, Australia.

Increase in meningococcal disease associated with the emergence of a novel ST-11 variant of serogroup C Neisseria meningitidis in Victoria, Australia, 1999–2000

  • D. E. TRIBE (a1), A. M. ZAIA (a2), J. M. GRIFFITH (a2), P. M. ROBINSON (a3), H. Y. LI (a2), K. N. TAYLOR (a3) and G. G. HOGG (a2)...

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